Hormonal changes in female bisphenol A treated sprague dawley rats at different time response / Mohd Faiz Bin Mohd Yazid

Bisphenol A (BPA) is one of the endocrine disrupting chemical due to its capacity to mimics or interfere with several hormones, including progesterone. It is widely used in the production of polycarbonate plastics and epoxy resins. In this study we investigated the effect of BPA exposure to progeste...

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Main Author:	Mohd Yazid, Mohd Faiz
Format:	Thesis
Language:	English
Published:	2009
Subjects:	Pharmaceutical industry
Online Access:	https://ir.uitm.edu.my/id/eprint/107213/1/107213.PDF
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id	my-uitm-ir.107213
record_format	uketd_dc
spelling	my-uitm-ir.1072132024-12-10T23:12:33Z Hormonal changes in female bisphenol A treated sprague dawley rats at different time response / Mohd Faiz Bin Mohd Yazid 2009 Mohd Yazid, Mohd Faiz Pharmaceutical industry Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) Bisphenol A (BPA) is one of the endocrine disrupting chemical due to its capacity to mimics or interfere with several hormones, including progesterone. It is widely used in the production of polycarbonate plastics and epoxy resins. In this study we investigated the effect of BPA exposure to progesterone level in Sprague Dawley (SD) rats for different time response (7, 14 and 28 days). Nine groups of rats were prepared for negative control, positive control and BPA treated with seven, fourteen and 28 days duration of treatment. Positive control groups were treated with 1.0 µg/kg/day ethinyl estradiol (EE) while BPA group were treated with 100 mg/kg/day of BPA via force feeding. Daily weight of the rats were recorded and the plasma level of progesterone was examined by using ELISA method. Independent-groups t test was then performed. The result showed that the progesterone concentration was not normally distributed and therefore, it is suggested that there was no significant differences of progesterone level in each treated groups (P>0.05). For the weight gain, there is no significance difference for seven days of treatment. Weight gain was significance between the negative and positive control group for fourteen days and 28 days of treatment respectively. 2009 Thesis https://ir.uitm.edu.my/id/eprint/107213/ https://ir.uitm.edu.my/id/eprint/107213/1/107213.PDF text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Pharmacy Hussin, Siti Nooraishah
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Hussin, Siti Nooraishah
topic	Pharmaceutical industry Pharmaceutical industry
spellingShingle	Pharmaceutical industry Pharmaceutical industry Mohd Yazid, Mohd Faiz Hormonal changes in female bisphenol A treated sprague dawley rats at different time response / Mohd Faiz Bin Mohd Yazid
description	Bisphenol A (BPA) is one of the endocrine disrupting chemical due to its capacity to mimics or interfere with several hormones, including progesterone. It is widely used in the production of polycarbonate plastics and epoxy resins. In this study we investigated the effect of BPA exposure to progesterone level in Sprague Dawley (SD) rats for different time response (7, 14 and 28 days). Nine groups of rats were prepared for negative control, positive control and BPA treated with seven, fourteen and 28 days duration of treatment. Positive control groups were treated with 1.0 µg/kg/day ethinyl estradiol (EE) while BPA group were treated with 100 mg/kg/day of BPA via force feeding. Daily weight of the rats were recorded and the plasma level of progesterone was examined by using ELISA method. Independent-groups t test was then performed. The result showed that the progesterone concentration was not normally distributed and therefore, it is suggested that there was no significant differences of progesterone level in each treated groups (P>0.05). For the weight gain, there is no significance difference for seven days of treatment. Weight gain was significance between the negative and positive control group for fourteen days and 28 days of treatment respectively.
format	Thesis
qualification_level	Bachelor degree
author	Mohd Yazid, Mohd Faiz
author_facet	Mohd Yazid, Mohd Faiz
author_sort	Mohd Yazid, Mohd Faiz
title	Hormonal changes in female bisphenol A treated sprague dawley rats at different time response / Mohd Faiz Bin Mohd Yazid
title_short	Hormonal changes in female bisphenol A treated sprague dawley rats at different time response / Mohd Faiz Bin Mohd Yazid
title_full	Hormonal changes in female bisphenol A treated sprague dawley rats at different time response / Mohd Faiz Bin Mohd Yazid
title_fullStr	Hormonal changes in female bisphenol A treated sprague dawley rats at different time response / Mohd Faiz Bin Mohd Yazid
title_full_unstemmed	Hormonal changes in female bisphenol A treated sprague dawley rats at different time response / Mohd Faiz Bin Mohd Yazid
title_sort	hormonal changes in female bisphenol a treated sprague dawley rats at different time response / mohd faiz bin mohd yazid
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Pharmacy
publishDate	2009
url	https://ir.uitm.edu.my/id/eprint/107213/1/107213.PDF
_version_	1818588215820419072

Hormonal changes in female bisphenol A treated sprague dawley rats at different time response / Mohd Faiz Bin Mohd Yazid

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