Elucidating vascular protective effect and molecular mechanisms of thymoquinone in homocysteine-induced endothelial dysfunction: ex vivo and in vitro model / Siti Sarah M. Sofiullah

Hyperhomocysteinemia (HHcy) has been linked to an increased risk of cardiovascular diseases. High levels of homocysteine (Hcy) cause damage to endothelial cells by promoting endoplasmic reticulum (ER) stress that increases reactive oxygen species (ROS), and cause endothelial nitric oxide synthase (e...

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Main Author:	M. Sofiullah, Siti Sarah
Format:	Thesis
Language:	English
Published:	2024
Subjects:	Diseases of the circulatory (Cardiovascular) system
Online Access:	https://ir.uitm.edu.my/id/eprint/107225/1/107225.pdf
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id	my-uitm-ir.107225
record_format	uketd_dc
spelling	my-uitm-ir.1072252024-12-04T08:27:17Z Elucidating vascular protective effect and molecular mechanisms of thymoquinone in homocysteine-induced endothelial dysfunction: ex vivo and in vitro model / Siti Sarah M. Sofiullah 2024 M. Sofiullah, Siti Sarah Diseases of the circulatory (Cardiovascular) system Hyperhomocysteinemia (HHcy) has been linked to an increased risk of cardiovascular diseases. High levels of homocysteine (Hcy) cause damage to endothelial cells by promoting endoplasmic reticulum (ER) stress that increases reactive oxygen species (ROS), and cause endothelial nitric oxide synthase (eNOS) uncoupling, leading to endothelial dysfunction. Thymoquinone (TQ) is the major active ingredient in Nigella sativa seeds volatile oil and is shown to have a cardioprotective effect. 2024 Thesis https://ir.uitm.edu.my/id/eprint/107225/ https://ir.uitm.edu.my/id/eprint/107225/1/107225.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Medicine
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Diseases of the circulatory (Cardiovascular) system
spellingShingle	Diseases of the circulatory (Cardiovascular) system M. Sofiullah, Siti Sarah Elucidating vascular protective effect and molecular mechanisms of thymoquinone in homocysteine-induced endothelial dysfunction: ex vivo and in vitro model / Siti Sarah M. Sofiullah
description	Hyperhomocysteinemia (HHcy) has been linked to an increased risk of cardiovascular diseases. High levels of homocysteine (Hcy) cause damage to endothelial cells by promoting endoplasmic reticulum (ER) stress that increases reactive oxygen species (ROS), and cause endothelial nitric oxide synthase (eNOS) uncoupling, leading to endothelial dysfunction. Thymoquinone (TQ) is the major active ingredient in Nigella sativa seeds volatile oil and is shown to have a cardioprotective effect.
format	Thesis
qualification_level	Master's degree
author	M. Sofiullah, Siti Sarah
author_facet	M. Sofiullah, Siti Sarah
author_sort	M. Sofiullah, Siti Sarah
title	Elucidating vascular protective effect and molecular mechanisms of thymoquinone in homocysteine-induced endothelial dysfunction: ex vivo and in vitro model / Siti Sarah M. Sofiullah
title_short	Elucidating vascular protective effect and molecular mechanisms of thymoquinone in homocysteine-induced endothelial dysfunction: ex vivo and in vitro model / Siti Sarah M. Sofiullah
title_full	Elucidating vascular protective effect and molecular mechanisms of thymoquinone in homocysteine-induced endothelial dysfunction: ex vivo and in vitro model / Siti Sarah M. Sofiullah
title_fullStr	Elucidating vascular protective effect and molecular mechanisms of thymoquinone in homocysteine-induced endothelial dysfunction: ex vivo and in vitro model / Siti Sarah M. Sofiullah
title_full_unstemmed	Elucidating vascular protective effect and molecular mechanisms of thymoquinone in homocysteine-induced endothelial dysfunction: ex vivo and in vitro model / Siti Sarah M. Sofiullah
title_sort	elucidating vascular protective effect and molecular mechanisms of thymoquinone in homocysteine-induced endothelial dysfunction: ex vivo and in vitro model / siti sarah m. sofiullah
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Medicine
publishDate	2024
url	https://ir.uitm.edu.my/id/eprint/107225/1/107225.pdf
_version_	1818588216594268160

Elucidating vascular protective effect and molecular mechanisms of thymoquinone in homocysteine-induced endothelial dysfunction: ex vivo and in vitro model / Siti Sarah M. Sofiullah

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