Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin

In recent years, technological advancements have brought us many innovative drug delivery systems. Among those, polymeric nanoparticles systems from biodegradable and biocompatible polymer are interesting option for drug delivery. Poly lactic-co glycolic acid) PLGA nanoparticles have gained attentio...

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Main Author:	Zainal Abidin, Suhaili
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Drugs and their actions Pharmaceutical technology
Online Access:	https://ir.uitm.edu.my/id/eprint/12215/2/12215.pdf
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spelling	my-uitm-ir.122152023-08-22T02:14:42Z Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin 2013 Zainal Abidin, Suhaili Drugs and their actions Pharmaceutical technology In recent years, technological advancements have brought us many innovative drug delivery systems. Among those, polymeric nanoparticles systems from biodegradable and biocompatible polymer are interesting option for drug delivery. Poly lactic-co glycolic acid) PLGA nanoparticles have gained attention for preparation of a wide variety of delivery systems containing several drugs. Nifedipine as a model drug is poorly soluble in water with low bioavailability. Loading nifedipine into PLGA nanoparticles may improve the solubility and bioavailability of the drug. Nifedipine loaded PLGA nanoparticles were prepared by solvent displacement method. For preparation of the PLGA nanoparticles, several parameters were investigated such as PLGA concentration, surfactant concentration, types of surfactants, technique of adding the solvent and ratio of aqueous to organic phases can be characterized by measuring the particle size, size distribution, zeta potential and morphology of PLGA nanoparticles. The results showed that the optimum formulations gave nanoparticles a smaller size and with better distribution and zeta potential. The surface morphology of nanoparticles images showed a spherical shape and smooth surface of blank PLGA nanoparticles and nifedipine loaded PLGA nanoparticles. The drug loaded PLGA nanoparticles were designed in three different formulations with 10, 20 and 30 % w/w of theoretical drug loading. The drug content and the drug entrapment increased with a rise in the theoretical drug loading. It was necessary to examine the interaction between the drug and the polymer during the preparation. The FTIR spectra were used to examine the interaction between the drug and the polymer. Comparing the characteristic absorption bands of nifedipine and PLGA that existed in nifedipine loaded PLGA nanoparticles, no chemical shift was found. In order to assess the in vivo release of nifedipine from PLGA nanoparticles, nifedipine level was measured in the rat plasma. 2013 Thesis https://ir.uitm.edu.my/id/eprint/12215/ https://ir.uitm.edu.my/id/eprint/12215/2/12215.pdf text en public mphil masters Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Sameni, Javad Khadem
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Sameni, Javad Khadem
topic	Drugs and their actions Pharmaceutical technology
spellingShingle	Drugs and their actions Pharmaceutical technology Zainal Abidin, Suhaili Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin
description	In recent years, technological advancements have brought us many innovative drug delivery systems. Among those, polymeric nanoparticles systems from biodegradable and biocompatible polymer are interesting option for drug delivery. Poly lactic-co glycolic acid) PLGA nanoparticles have gained attention for preparation of a wide variety of delivery systems containing several drugs. Nifedipine as a model drug is poorly soluble in water with low bioavailability. Loading nifedipine into PLGA nanoparticles may improve the solubility and bioavailability of the drug. Nifedipine loaded PLGA nanoparticles were prepared by solvent displacement method. For preparation of the PLGA nanoparticles, several parameters were investigated such as PLGA concentration, surfactant concentration, types of surfactants, technique of adding the solvent and ratio of aqueous to organic phases can be characterized by measuring the particle size, size distribution, zeta potential and morphology of PLGA nanoparticles. The results showed that the optimum formulations gave nanoparticles a smaller size and with better distribution and zeta potential. The surface morphology of nanoparticles images showed a spherical shape and smooth surface of blank PLGA nanoparticles and nifedipine loaded PLGA nanoparticles. The drug loaded PLGA nanoparticles were designed in three different formulations with 10, 20 and 30 % w/w of theoretical drug loading. The drug content and the drug entrapment increased with a rise in the theoretical drug loading. It was necessary to examine the interaction between the drug and the polymer during the preparation. The FTIR spectra were used to examine the interaction between the drug and the polymer. Comparing the characteristic absorption bands of nifedipine and PLGA that existed in nifedipine loaded PLGA nanoparticles, no chemical shift was found. In order to assess the in vivo release of nifedipine from PLGA nanoparticles, nifedipine level was measured in the rat plasma.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Zainal Abidin, Suhaili
author_facet	Zainal Abidin, Suhaili
author_sort	Zainal Abidin, Suhaili
title	Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin
title_short	Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin
title_full	Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin
title_fullStr	Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin
title_full_unstemmed	Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin
title_sort	preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable plga nanoparticles for improved oral bioavailability / suhaili zainal abidin
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2013
url	https://ir.uitm.edu.my/id/eprint/12215/2/12215.pdf
_version_	1783733168078061568

Preparation characterization and in vivo evaluation of nifedipine-loaded biodegradable PLGA nanoparticles for improved oral bioavailability / Suhaili Zainal Abidin

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