Centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / Nafisah Musa
Conventional melt pelletization and granulation processes produce round and dense, and irregularly shaped but porous agglomerates respectively. This study aimed to design centrifugal air-assisted melt agglomeration technology for manufacture of spherical and yet porous "granulets" for e...
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my-uitm-ir.129992023-02-07T04:09:34Z Centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / Nafisah Musa 2012 Musa, Nafisah Drugs and their actions RS Pharmacy and materia medica Conventional melt pelletization and granulation processes produce round and dense, and irregularly shaped but porous agglomerates respectively. This study aimed to design centrifugal air-assisted melt agglomeration technology for manufacture of spherical and yet porous "granulets" for ease of downstream manufacturing and enhancing drug release. A bladeless agglomerator, which utilized shear-free air stream to mass the powder mixture of lactose filler, polyethylene glycol binder and poorly water-soluble tolbutamide drug into "granulets", was developed. The inclination angle and number of vane, air-impermeable surface area of air guide, processing temperature, binder content and molecular weight were investigated with reference to "granulet" size, shape, texture and drug release properties. Unlike fluid-bed melt agglomeration with vertical processing air flow, the air stream in the present technology moved centrifugally to roll the processing mass into spherical but porous "granulets" with a drug release propensity higher than physical powder mixture, unprocessed drug and dense pellets prepared using high shear mixer. The fast-release attribute of "granulets" was ascribed to porous matrix formed with a high level of polyethylene glycol as solubilizer. The agglomeration and drug release outcomes of centrifugal air-assisted technology are unmet by the existing high shear and fluid-bed melt agglomeration techniques. 2012 Thesis https://ir.uitm.edu.my/id/eprint/12999/ https://ir.uitm.edu.my/id/eprint/12999/2/12999.pdf text en public mphil masters Universiti Teknologi MARA Perpustakaan Tun Abdul Razak |
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Universiti Teknologi MARA |
| collection |
UiTM Institutional Repository |
| language |
English |
| topic |
Drugs and their actions RS Pharmacy and materia medica |
| spellingShingle |
Drugs and their actions RS Pharmacy and materia medica Musa, Nafisah Centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / Nafisah Musa |
| description |
Conventional melt pelletization and granulation processes produce round and dense,
and irregularly shaped but porous agglomerates respectively. This study aimed to
design centrifugal air-assisted melt agglomeration technology for manufacture of
spherical and yet porous "granulets" for ease of downstream manufacturing and
enhancing drug release. A bladeless agglomerator, which utilized shear-free air stream
to mass the powder mixture of lactose filler, polyethylene glycol binder and poorly
water-soluble tolbutamide drug into "granulets", was developed. The inclination angle
and number of vane, air-impermeable surface area of air guide, processing
temperature, binder content and molecular weight were investigated with reference to
"granulet" size, shape, texture and drug release properties. Unlike fluid-bed melt
agglomeration with vertical processing air flow, the air stream in the present
technology moved centrifugally to roll the processing mass into spherical but porous
"granulets" with a drug release propensity higher than physical powder mixture,
unprocessed drug and dense pellets prepared using high shear mixer. The fast-release
attribute of "granulets" was ascribed to porous matrix formed with a high level of
polyethylene glycol as solubilizer. The agglomeration and drug release outcomes of
centrifugal air-assisted technology are unmet by the existing high shear and fluid-bed
melt agglomeration techniques. |
| format |
Thesis |
| qualification_name |
Master of Philosophy (M.Phil.) |
| qualification_level |
Master's degree |
| author |
Musa, Nafisah |
| author_facet |
Musa, Nafisah |
| author_sort |
Musa, Nafisah |
| title |
Centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / Nafisah Musa |
| title_short |
Centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / Nafisah Musa |
| title_full |
Centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / Nafisah Musa |
| title_fullStr |
Centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / Nafisah Musa |
| title_full_unstemmed |
Centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / Nafisah Musa |
| title_sort |
centrifugal air-assisted melt agglomeration for fast-release "granulet" design : development of a bladeless prototype / nafisah musa |
| granting_institution |
Universiti Teknologi MARA |
| granting_department |
Perpustakaan Tun Abdul Razak |
| publishDate |
2012 |
| url |
https://ir.uitm.edu.my/id/eprint/12999/2/12999.pdf |
| _version_ |
1783733170848399360 |