Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir

The relationship of high and low molecular weight mannuronic acid (M)- and guluronic acid (G)-rich alginate nanoparticles as oral insulin carrier was elucidated. Nanoparticles were prepared through ionotropic gelation using Ca2 +, and then in vitro physicochemical attributes and in vivo antidiabeti...

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Main Author:	Kadir, Aminah
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Oral and dental medicine Pathology Diseases Pharmaceutical technology
Online Access:	https://ir.uitm.edu.my/id/eprint/13853/1/TM_AMINAH%20KADIR%20PH%2015_5%201.pdf
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id	my-uitm-ir.13853
record_format	uketd_dc
spelling	my-uitm-ir.138532022-03-01T02:25:59Z Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir 2015 Kadir, Aminah Oral and dental medicine. Pathology. Diseases Pharmaceutical technology The relationship of high and low molecular weight mannuronic acid (M)- and guluronic acid (G)-rich alginate nanoparticles as oral insulin carrier was elucidated. Nanoparticles were prepared through ionotropic gelation using Ca2 +, and then in vitro physicochemical attributes and in vivo antidiabetic characteristics were examined. The alginate nanoparticles had insulin release retarded when the matrices had high alginate-to-insulin ratio or strong alginate-insulin interaction via O-H moiety. High molecular weight M-rich alginate nanoparticles were characterized by assemblies of long polymer chains that enabled insulin encapsulation with weaker polymer-drug interaction than nanoparticles prepared from other alginate grades. They were able to encapsulate and yet release and have insulin absorbed into systemic circulation, thereby lowering rat blood glucose. High molecular weight G- and low molecular weight M-rich alginate nanoparticles showed remarkable polymer-insulin interaction. This retarded the drug release and negated its absorption. Blood glucose lowering was, however, demonstrated in vivo with insulin-free matrices of these nanoparticles because of the strong alginate-glucose binding that led to intestinal glucose retention. Alginate nanoparticles can be used as oral insulin carrier or glucose binder in the treatment of diabetes as a function of its chemical composition. High molecular weight M-rich alginate nanoparticles are a suitable vehicle for future development into oral insulin carrier 2015 Thesis https://ir.uitm.edu.my/id/eprint/13853/ https://ir.uitm.edu.my/id/eprint/13853/1/TM_AMINAH%20KADIR%20PH%2015_5%201.pdf text en public mphil masters Universiti Teknologi MARA Perpustakaan Tun Abdul Razak
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Oral and dental medicine Pathology Diseases Pharmaceutical technology
spellingShingle	Oral and dental medicine Pathology Diseases Pharmaceutical technology Kadir, Aminah Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
description	The relationship of high and low molecular weight mannuronic acid (M)- and guluronic acid (G)-rich alginate nanoparticles as oral insulin carrier was elucidated. Nanoparticles were prepared through ionotropic gelation using Ca2 +, and then in vitro physicochemical attributes and in vivo antidiabetic characteristics were examined. The alginate nanoparticles had insulin release retarded when the matrices had high alginate-to-insulin ratio or strong alginate-insulin interaction via O-H moiety. High molecular weight M-rich alginate nanoparticles were characterized by assemblies of long polymer chains that enabled insulin encapsulation with weaker polymer-drug interaction than nanoparticles prepared from other alginate grades. They were able to encapsulate and yet release and have insulin absorbed into systemic circulation, thereby lowering rat blood glucose. High molecular weight G- and low molecular weight M-rich alginate nanoparticles showed remarkable polymer-insulin interaction. This retarded the drug release and negated its absorption. Blood glucose lowering was, however, demonstrated in vivo with insulin-free matrices of these nanoparticles because of the strong alginate-glucose binding that led to intestinal glucose retention. Alginate nanoparticles can be used as oral insulin carrier or glucose binder in the treatment of diabetes as a function of its chemical composition. High molecular weight M-rich alginate nanoparticles are a suitable vehicle for future development into oral insulin carrier
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Kadir, Aminah
author_facet	Kadir, Aminah
author_sort	Kadir, Aminah
title	Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
title_short	Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
title_full	Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
title_fullStr	Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
title_full_unstemmed	Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir
title_sort	design of alginate nanoparticles as oral insulin carrier / aminah kadir
granting_institution	Universiti Teknologi MARA
granting_department	Perpustakaan Tun Abdul Razak
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/13853/1/TM_AMINAH%20KADIR%20PH%2015_5%201.pdf
_version_	1783733184392855552

Design of alginate nanoparticles as oral insulin carrier / Aminah Kadir

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