Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong

The leaves of Ficus deltoidea are used as a traditional medicine by diabetes patients in Malaysia. The objective of the study is to identify and evaluate bioactive constituents with in vivo a-glucosidase inhibition. The partitioned extracts, subfractions and pure bioactive constituents were subjecte...

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Main Author:	Sulong, Nor Akmal Yati
Format:	Thesis
Language:	English
Published:	2014
Subjects:	Medical botany (General)
Online Access:	https://ir.uitm.edu.my/id/eprint/14099/1/TM_NOR%20AKMAL%20YATI%20SULONG%20PH%2014_5.pdf
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id	my-uitm-ir.14099
record_format	uketd_dc
spelling	my-uitm-ir.140992022-03-03T08:16:10Z Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong 2014 Sulong, Nor Akmal Yati Medical botany (General) Bioflavonoids. Vitamin P Herbs. Herbal teas The leaves of Ficus deltoidea are used as a traditional medicine by diabetes patients in Malaysia. The objective of the study is to identify and evaluate bioactive constituents with in vivo a-glucosidase inhibition. The partitioned extracts, subfractions and pure bioactive constituents were subjected to the in vitro and in vivo a-glucosidase inhibition assay. The identified bioactive constituents were administered orally to sucrose loaded normoglycemic mice and induced diabetic rats. The postprandial blood glucose levels were monitored at 30 min interval. Acute toxicity was evaluated in both normoglycemic mice and induced diabetic rats. Bioactivity guided fractionation led to the isolation of C-glycosyl bioflavonoids namely,vitexin (78) and isovitexin (79). Oral administration of 1 mg/kg of either vitexin or isovitexin significantly (p<0.05) reduced the postprandial blood glucose level in sucrose loaded normoglycemic mice at 30 min. The percentage of postprandial blood glucose reduction was highest in sucrose loaded induced diabetic rats administered orally with 200 mg/kg of vitexin or 100 mg/kg of isovitexin. Both vitexin and isovitexin did not exert any signs of toxicity at the highest dose of 2 g/kg administered orally to normoglycemic mice and induced diabetic rats. Both the C-glycosyl bioflavonoids, namely, vitexin and isovitexin exhibited in vivo a-glucosidase inhibition. 2014 Thesis https://ir.uitm.edu.my/id/eprint/14099/ https://ir.uitm.edu.my/id/eprint/14099/1/TM_NOR%20AKMAL%20YATI%20SULONG%20PH%2014_5.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Medical botany (General) Medical botany (General) Medical botany (General)
spellingShingle	Medical botany (General) Medical botany (General) Medical botany (General) Sulong, Nor Akmal Yati Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
description	The leaves of Ficus deltoidea are used as a traditional medicine by diabetes patients in Malaysia. The objective of the study is to identify and evaluate bioactive constituents with in vivo a-glucosidase inhibition. The partitioned extracts, subfractions and pure bioactive constituents were subjected to the in vitro and in vivo a-glucosidase inhibition assay. The identified bioactive constituents were administered orally to sucrose loaded normoglycemic mice and induced diabetic rats. The postprandial blood glucose levels were monitored at 30 min interval. Acute toxicity was evaluated in both normoglycemic mice and induced diabetic rats. Bioactivity guided fractionation led to the isolation of C-glycosyl bioflavonoids namely,vitexin (78) and isovitexin (79). Oral administration of 1 mg/kg of either vitexin or isovitexin significantly (p<0.05) reduced the postprandial blood glucose level in sucrose loaded normoglycemic mice at 30 min. The percentage of postprandial blood glucose reduction was highest in sucrose loaded induced diabetic rats administered orally with 200 mg/kg of vitexin or 100 mg/kg of isovitexin. Both vitexin and isovitexin did not exert any signs of toxicity at the highest dose of 2 g/kg administered orally to normoglycemic mice and induced diabetic rats. Both the C-glycosyl bioflavonoids, namely, vitexin and isovitexin exhibited in vivo a-glucosidase inhibition.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Sulong, Nor Akmal Yati
author_facet	Sulong, Nor Akmal Yati
author_sort	Sulong, Nor Akmal Yati
title	Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
title_short	Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
title_full	Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
title_fullStr	Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
title_full_unstemmed	Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong
title_sort	bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / nor akmal yati sulong
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2014
url	https://ir.uitm.edu.my/id/eprint/14099/1/TM_NOR%20AKMAL%20YATI%20SULONG%20PH%2014_5.pdf
_version_	1783733213006397440

Bioflavonoids from the leaves of ficus deltoidea jack with a-glucosidase inhibition / Nor Akmal Yati Sulong

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