Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar
Five Schiff base ligands were successful synthesized from 1,8-diaminonaphthalene with 2-hydroacetophenone, 5-bromo-2-hydroxyacetophenone, salicyldehyde, 2-4,dihydroxybenayldehyde and 3-hydroxy-4-methoxybenzaldehyde in the ratio 1:2. Twenty complexes of Cu(II), Co(II), Ni(II) and Zn(II) with the five...
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my-uitm-ir.155282022-04-18T02:11:29Z Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar 2013-08 Abu Bakar, Ahmad Fauzi Bioactive compounds Five Schiff base ligands were successful synthesized from 1,8-diaminonaphthalene with 2-hydroacetophenone, 5-bromo-2-hydroxyacetophenone, salicyldehyde, 2-4,dihydroxybenayldehyde and 3-hydroxy-4-methoxybenzaldehyde in the ratio 1:2. Twenty complexes of Cu(II), Co(II), Ni(II) and Zn(II) with the five ligands were obtained with 1:1 ratio of ligand:metal. The chemical structures were investigated and elucidated using elemental analysis (C,H,N), infrared spectroscopy, 1 H and 13C nuclear magnetic resonance spectroscopy, ultraviolet-visible spectroscopy, melting point measurement and magnetic susceptibility measurement. The paramagnetic Cu(II) and Co(II) complexes were observed to display v(C=N) band in the range 1601 to 1638 cm'1, while those of the diamagnetic Ni(II) and Zn(II) complexes displayed v(C=N) band in the region 1587 to 1638 cm'1. From the effective magnetic moment (|^eff) values, it was indicate that the nickel(II) complexes adopted square planar geometry while all the cobalt(II) complexes were tetrahedral. The representative compounds of CoLl and LI showed UV-Vis absorption bands at 260 to 332 nm assignable to n—>n* transition of the aromatic systems. The band at 298 nm for ligand was likely due to n—>n* and tt— electron transitions of the conjugated C=C chromophore of the naphthalene and phenyl moieties. Absorption for cobalt(II) complex showed a bathocromical shift to the free ligand, caused by the coordination of metal to the ligand, in agreement with the IR spectral results. The neurotoxicity screening on treated human neuroblastoma SH-SY5Y cell lines revealed that the compound were not toxic to the cell line. 2013-08 Thesis https://ir.uitm.edu.my/id/eprint/15528/ https://ir.uitm.edu.my/id/eprint/15528/1/TM_AHMAD%20FAUZI%20ABU%20BAKAR%20AS%2013_5.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Applied Science Bahron, Hadariah (Professor Dr.) Kassim, Karimah (Dr.) |
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Universiti Teknologi MARA |
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English |
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Bahron, Hadariah (Professor Dr.) Kassim, Karimah (Dr.) |
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Bioactive compounds |
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Bioactive compounds Abu Bakar, Ahmad Fauzi Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
description |
Five Schiff base ligands were successful synthesized from 1,8-diaminonaphthalene with 2-hydroacetophenone, 5-bromo-2-hydroxyacetophenone, salicyldehyde, 2-4,dihydroxybenayldehyde and 3-hydroxy-4-methoxybenzaldehyde in the ratio 1:2. Twenty complexes of Cu(II), Co(II), Ni(II) and Zn(II) with the five ligands were obtained with 1:1 ratio of ligand:metal. The chemical structures were investigated and elucidated using elemental analysis (C,H,N), infrared spectroscopy, 1 H and 13C nuclear magnetic resonance spectroscopy, ultraviolet-visible spectroscopy, melting point measurement and magnetic susceptibility measurement. The paramagnetic Cu(II) and Co(II) complexes were observed to display v(C=N) band in the range 1601 to 1638 cm'1, while those of the diamagnetic Ni(II) and Zn(II) complexes displayed v(C=N) band in the region 1587 to 1638 cm'1. From the effective magnetic moment (|^eff) values, it was indicate that the nickel(II) complexes adopted square planar geometry while all the cobalt(II) complexes were tetrahedral. The representative compounds of CoLl and LI showed UV-Vis absorption bands at 260 to 332 nm assignable to n—>n* transition of the aromatic systems. The band at 298 nm for ligand was likely due to n—>n* and tt— electron transitions of the conjugated C=C chromophore of the naphthalene and phenyl moieties. Absorption for cobalt(II) complex showed a bathocromical shift to the free ligand, caused by the coordination of metal to the ligand, in agreement with the IR spectral results. The neurotoxicity screening on treated human neuroblastoma SH-SY5Y cell lines revealed that the compound were not toxic to the cell line. |
format |
Thesis |
qualification_name |
Master of Philosophy (M.Phil.) |
qualification_level |
Master's degree |
author |
Abu Bakar, Ahmad Fauzi |
author_facet |
Abu Bakar, Ahmad Fauzi |
author_sort |
Abu Bakar, Ahmad Fauzi |
title |
Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
title_short |
Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
title_full |
Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
title_fullStr |
Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
title_full_unstemmed |
Synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-Diaminonaphthalene and their Cu(ii), Co(ii), Ni(ii) and Zn(ii) complexes / Ahmad Fauzi Abu Bakar |
title_sort |
synthesis, characterization and neurotoxicity screening of schiff base ligands derived from 1,8-diaminonaphthalene and their cu(ii), co(ii), ni(ii) and zn(ii) complexes / ahmad fauzi abu bakar |
granting_institution |
Universiti Teknologi MARA |
granting_department |
Faculty of Applied Science |
publishDate |
2013 |
url |
https://ir.uitm.edu.my/id/eprint/15528/1/TM_AHMAD%20FAUZI%20ABU%20BAKAR%20AS%2013_5.pdf |
_version_ |
1783733415592329216 |