Influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / Nur Zahirah Mohamad Zin

Since the last decade, various formulation and processing approaches have been introduced in drug delivery system design to negate the propensity o f drug release from dosage form in the acidic gastric region. Extrusion-spheronization is one of the processing approaches that is extensively used in t...

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Main Author:	Mohamad Zin, Nur Zahirah
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Analytical chemistry Drugs and their actions
Online Access:	https://ir.uitm.edu.my/id/eprint/15773/1/TM_NUR%20ZAHIRAH%20MOHAMAD%20ZIN%20PH%2015_5.PDF
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spelling	my-uitm-ir.157732022-03-03T08:52:25Z Influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / Nur Zahirah Mohamad Zin 2015 Mohamad Zin, Nur Zahirah Analytical chemistry General. Including influence of the environment Drugs and their actions Since the last decade, various formulation and processing approaches have been introduced in drug delivery system design to negate the propensity o f drug release from dosage form in the acidic gastric region. Extrusion-spheronization is one of the processing approaches that is extensively used in the production o f multi-particulate system for oral controlled drug delivery. Polysaccharides have been employed in the formulation of pharmaceutical drug delivery system for small molecule drug. Nevertheless, the formed matrix frequently is found to have a porous structure. Consequently, this results in an uncontrollably fast release rate of small molecule drug. Such rate of drug release is undesirable in the case o f the need to target the drugs to the lower part of gastrointestinal tract, particularly, the colon. Alginate is a type of polysaccharide that has been employed in the formulation of pharmaceutical drug delivery system for small molecule drug. It is produced from brown seaweeds, and is biocompatible, non-toxic, non-immunogenic and biodegradable. The present study investigates small molecule drug release from spheroids prepared from mannuronic acid-rich alginate. The drug release property of these spheroids was examined with reference to additive and microwave effects as formulation and processing variables respectively. The spheroids were prepared by extrusion-spheronization technique using microcrystalline cellulose as spheronization aid, zinc chloride as crosslinking agent, chlorpheniramine maleate as model water-soluble drug, stearic acid and 1 2 - hydroxystearic acid as additives. The formed spheroids were subjected to size, shape, drug content, drug release, zinc release, Fourier Transform Infrared spectroscopy, Differential Scanning Calorimetry and surface morphology analysis. They were treated by microwave at 80 W for 5 to 40 min when required. Alginate spheroids demonstrated a fast drug release characteristics and such fast release attribute can be reduced through zinc alginate crosslinkage formation. The zinc alginate spheroids exhibited a lower level o f drug release despite the matrix was disintegrated into fines particles which had a larger specific surface area for drug dissolution. Loading of stearic acid or 1 2 -hydroxystearic acid into alginate or zinc alginate spheroids did not substantially retard drug release though these fatty acids were relatively hydrophobic. Overall, the treatment o f alginate-based spheroids by microwave tended to bring minor changes in drug release property except that o f zinc alginate-1 2 -hydroxystearic acid spheroids where O-H moiety o f fatty acid and alginate increasingly responded to the influence o f microwave. 2015 Thesis https://ir.uitm.edu.my/id/eprint/15773/ https://ir.uitm.edu.my/id/eprint/15773/1/TM_NUR%20ZAHIRAH%20MOHAMAD%20ZIN%20PH%2015_5.PDF text en public mphil masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Analytical chemistry Analytical chemistry Drugs and their actions
spellingShingle	Analytical chemistry Analytical chemistry Drugs and their actions Mohamad Zin, Nur Zahirah Influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / Nur Zahirah Mohamad Zin
description	Since the last decade, various formulation and processing approaches have been introduced in drug delivery system design to negate the propensity o f drug release from dosage form in the acidic gastric region. Extrusion-spheronization is one of the processing approaches that is extensively used in the production o f multi-particulate system for oral controlled drug delivery. Polysaccharides have been employed in the formulation of pharmaceutical drug delivery system for small molecule drug. Nevertheless, the formed matrix frequently is found to have a porous structure. Consequently, this results in an uncontrollably fast release rate of small molecule drug. Such rate of drug release is undesirable in the case o f the need to target the drugs to the lower part of gastrointestinal tract, particularly, the colon. Alginate is a type of polysaccharide that has been employed in the formulation of pharmaceutical drug delivery system for small molecule drug. It is produced from brown seaweeds, and is biocompatible, non-toxic, non-immunogenic and biodegradable. The present study investigates small molecule drug release from spheroids prepared from mannuronic acid-rich alginate. The drug release property of these spheroids was examined with reference to additive and microwave effects as formulation and processing variables respectively. The spheroids were prepared by extrusion-spheronization technique using microcrystalline cellulose as spheronization aid, zinc chloride as crosslinking agent, chlorpheniramine maleate as model water-soluble drug, stearic acid and 1 2 - hydroxystearic acid as additives. The formed spheroids were subjected to size, shape, drug content, drug release, zinc release, Fourier Transform Infrared spectroscopy, Differential Scanning Calorimetry and surface morphology analysis. They were treated by microwave at 80 W for 5 to 40 min when required. Alginate spheroids demonstrated a fast drug release characteristics and such fast release attribute can be reduced through zinc alginate crosslinkage formation. The zinc alginate spheroids exhibited a lower level o f drug release despite the matrix was disintegrated into fines particles which had a larger specific surface area for drug dissolution. Loading of stearic acid or 1 2 -hydroxystearic acid into alginate or zinc alginate spheroids did not substantially retard drug release though these fatty acids were relatively hydrophobic. Overall, the treatment o f alginate-based spheroids by microwave tended to bring minor changes in drug release property except that o f zinc alginate-1 2 -hydroxystearic acid spheroids where O-H moiety o f fatty acid and alginate increasingly responded to the influence o f microwave.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Mohamad Zin, Nur Zahirah
author_facet	Mohamad Zin, Nur Zahirah
author_sort	Mohamad Zin, Nur Zahirah
title	Influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / Nur Zahirah Mohamad Zin
title_short	Influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / Nur Zahirah Mohamad Zin
title_full	Influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / Nur Zahirah Mohamad Zin
title_fullStr	Influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / Nur Zahirah Mohamad Zin
title_full_unstemmed	Influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / Nur Zahirah Mohamad Zin
title_sort	influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / nur zahirah mohamad zin
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/15773/1/TM_NUR%20ZAHIRAH%20MOHAMAD%20ZIN%20PH%2015_5.PDF
_version_	1783733449007300608

Influences of microwave on drug dissolution profiles of mannuronic acid-rich alginate spheroids / Nur Zahirah Mohamad Zin

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