Yap (Y alu polymorphism) signature in six Malay sub-ethnic groups in Peninsular Malaysia / Muhd Shah Jehan Abd Razak

Malay sub-ethnic groups in Peninsular Malaysia have a rich culture and tradition such as historical knowledge and heritage, which might be reflected in the current genetic makeup of this population. They are a mixture of different races that were caused by the history of migration centuries ago and...

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Main Author:	Abd. Razak, Muhd Shah Jehan
Format:	Thesis
Language:	English
Published:	2015
Subjects:	QP Physiology
Online Access:	https://ir.uitm.edu.my/id/eprint/15827/2/15827.pdf
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id	my-uitm-ir.15827
record_format	uketd_dc
spelling	my-uitm-ir.158272022-11-24T03:54:23Z Yap (Y alu polymorphism) signature in six Malay sub-ethnic groups in Peninsular Malaysia / Muhd Shah Jehan Abd Razak 2015-10 Abd. Razak, Muhd Shah Jehan QP Physiology Malay sub-ethnic groups in Peninsular Malaysia have a rich culture and tradition such as historical knowledge and heritage, which might be reflected in the current genetic makeup of this population. They are a mixture of different races that were caused by the history of migration centuries ago and consisted of 14 Malay sub-ethnic groups in Peninsular Malaysia. The objective of this study was to analyze the genetic polymorphism of Y chromosome at DYS287 Y Alu Polymorphism (YAP) locus in six Malay sub-ethnic groups of Peninsular Malaysia. A total of 231 buccal cells from healthy unrelated individual males consisting of 117 Kelantan-Malay, 50 Jawa-Malay, 48 Minangkabau-Malay, 9 Banjar Malay, 3 Bugis-Malay and 4 Rao-Malay from different regions of Peninsular Malaysia were screened for the DYS287 Y Alu locus from their genomic DNA. It shows that Kelantan-Malay, Jawa-Malay, Minangkabau-Malay, Banjar-Malay, Bugis-Malay and Rao-Malayare completely absent of theDYS287 Y Alu Polymorphism. Sequence results revealed that all Malay sub-ethnic of Peninsular Malaysia groups studied do not carry the number of 45bp (long) and 28bp (short) with association of long adenine (A)residues at [poly(A) tail] of theAlu sequence at DYS287 locus. Allele frequency for YAP+ was absent in all Malay sub-ethnic groups in Peninsular Malaysia. They were no genetic differences between the studied Malay subethnic groups of DYS287 locus. This study has provided information on the pattern of DYS287 Y Alu Polymorphism in Kelantan-Malay, Jawa-Malay, Minangkabau-Malay, Banjar-Malay, Bugis-Malay and Rao-Malay sub-ethnic group in Peninsular Malaysia. Further study will be done on more samples of the other Malay sub-ethnic groups in Peninsular Malaysia to determine more DYS287 Y Alu Polymorphism status. 2015-10 Thesis https://ir.uitm.edu.my/id/eprint/15827/ https://ir.uitm.edu.my/id/eprint/15827/2/15827.pdf text en public mphil masters Universiti Teknologi MARA Faculty Applied Sciences Haji Mohd Yusof, Farida Zuraina (Assoc. Prof. Dr. Hjh.) Wan Hanafi, Wan Nurhayati
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Haji Mohd Yusof, Farida Zuraina (Assoc. Prof. Dr. Hjh.) Wan Hanafi, Wan Nurhayati
topic	QP Physiology
spellingShingle	QP Physiology Abd. Razak, Muhd Shah Jehan Yap (Y alu polymorphism) signature in six Malay sub-ethnic groups in Peninsular Malaysia / Muhd Shah Jehan Abd Razak
description	Malay sub-ethnic groups in Peninsular Malaysia have a rich culture and tradition such as historical knowledge and heritage, which might be reflected in the current genetic makeup of this population. They are a mixture of different races that were caused by the history of migration centuries ago and consisted of 14 Malay sub-ethnic groups in Peninsular Malaysia. The objective of this study was to analyze the genetic polymorphism of Y chromosome at DYS287 Y Alu Polymorphism (YAP) locus in six Malay sub-ethnic groups of Peninsular Malaysia. A total of 231 buccal cells from healthy unrelated individual males consisting of 117 Kelantan-Malay, 50 Jawa-Malay, 48 Minangkabau-Malay, 9 Banjar Malay, 3 Bugis-Malay and 4 Rao-Malay from different regions of Peninsular Malaysia were screened for the DYS287 Y Alu locus from their genomic DNA. It shows that Kelantan-Malay, Jawa-Malay, Minangkabau-Malay, Banjar-Malay, Bugis-Malay and Rao-Malayare completely absent of theDYS287 Y Alu Polymorphism. Sequence results revealed that all Malay sub-ethnic of Peninsular Malaysia groups studied do not carry the number of 45bp (long) and 28bp (short) with association of long adenine (A)residues at [poly(A) tail] of theAlu sequence at DYS287 locus. Allele frequency for YAP+ was absent in all Malay sub-ethnic groups in Peninsular Malaysia. They were no genetic differences between the studied Malay subethnic groups of DYS287 locus. This study has provided information on the pattern of DYS287 Y Alu Polymorphism in Kelantan-Malay, Jawa-Malay, Minangkabau-Malay, Banjar-Malay, Bugis-Malay and Rao-Malay sub-ethnic group in Peninsular Malaysia. Further study will be done on more samples of the other Malay sub-ethnic groups in Peninsular Malaysia to determine more DYS287 Y Alu Polymorphism status.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Abd. Razak, Muhd Shah Jehan
author_facet	Abd. Razak, Muhd Shah Jehan
author_sort	Abd. Razak, Muhd Shah Jehan
title	Yap (Y alu polymorphism) signature in six Malay sub-ethnic groups in Peninsular Malaysia / Muhd Shah Jehan Abd Razak
title_short	Yap (Y alu polymorphism) signature in six Malay sub-ethnic groups in Peninsular Malaysia / Muhd Shah Jehan Abd Razak
title_full	Yap (Y alu polymorphism) signature in six Malay sub-ethnic groups in Peninsular Malaysia / Muhd Shah Jehan Abd Razak
title_fullStr	Yap (Y alu polymorphism) signature in six Malay sub-ethnic groups in Peninsular Malaysia / Muhd Shah Jehan Abd Razak
title_full_unstemmed	Yap (Y alu polymorphism) signature in six Malay sub-ethnic groups in Peninsular Malaysia / Muhd Shah Jehan Abd Razak
title_sort	yap (y alu polymorphism) signature in six malay sub-ethnic groups in peninsular malaysia / muhd shah jehan abd razak
granting_institution	Universiti Teknologi MARA
granting_department	Faculty Applied Sciences
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/15827/2/15827.pdf
_version_	1783733455984525312

Yap (Y alu polymorphism) signature in six Malay sub-ethnic groups in Peninsular Malaysia / Muhd Shah Jehan Abd Razak

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