The role of toxoplasma gondii (Tg) in schizophrenia: serofrequency and serointensity of Tg / Nor Fatini Adam

Infection with Toxoplasma gondii (Tg) in the central nervous system causes behavioural, personality changes and psychotic symptoms mimicking schizophrenia, a psychiatric illness with unknown aetiology. The aim of this study was to determine the seroprevalence, serointensity of Tg IgG, IgM antibodies...

Full description

Saved in:

Bibliographic Details
Main Author:	Adam, Nor Fatini
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Medicine and disease in relation to psychology Terminal care Dying Neurotoxicology
Online Access:	https://ir.uitm.edu.my/id/eprint/16005/1/TM_NOR%20FATINI%20ADAM%20MD%2015_5.PDF
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.16005
record_format	uketd_dc
spelling	my-uitm-ir.160052022-03-10T02:50:27Z The role of toxoplasma gondii (Tg) in schizophrenia: serofrequency and serointensity of Tg / Nor Fatini Adam 2015 Adam, Nor Fatini Medicine and disease in relation to psychology. Terminal care. Dying Neurotoxicology Infection with Toxoplasma gondii (Tg) in the central nervous system causes behavioural, personality changes and psychotic symptoms mimicking schizophrenia, a psychiatric illness with unknown aetiology. The aim of this study was to determine the seroprevalence, serointensity of Tg IgG, IgM antibodies and Tg DNA in patients with Schizophrenia and its relationship with demographic profile and clinical factors. This was a cross-sectional study examining the role of Tg in patients with Schizophrenia attending the Sg Buloh Hospital and University Malaya Medical Centre (UMMC) during a period from July 2010 to December 2012. A total of 156 subjects consisting of 57 patients with chronic Schizophrenia, 44 acute Schizophrenia and 55 healthy individuals participated in this study. The demographic profiles, risks and clinical factors were examined to determine the positivity and intensity of Tg IgG, IgM antibodies and Tg DNA. The seropositivity and serointensity of Tg antibodies were measured using Enzyme Linked Immunosorbent Assay (ELISA) while positivity and intensity Tg DNA were measured using Real Time PCR. The seropositivity of IgG antibody were significantly higher in all Schizophrenia, remission and acute Schizophrenia patients than control (p<0.001). The serointensity of IgG antibody were also significantly higher in all Schizophrenia, remission and acute Schizophrenia patients than control (p<0.05). The positivity of DNA Tg were also significantly higher in all Schizophrenia, remission and acute schizophrenia than control (p<0.05).The intensity of Tg DNA were also significantly higher in all Schizophrenia,remission and acute Schizophrenia patients than control (p<0.05). This study suggests that Tg has a significant role in Schizophrenia. 2015 Thesis https://ir.uitm.edu.my/id/eprint/16005/ https://ir.uitm.edu.my/id/eprint/16005/1/TM_NOR%20FATINI%20ADAM%20MD%2015_5.PDF text en public mphil masters Universiti Teknologi MARA Faculty of Medicine
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Medicine and disease in relation to psychology Terminal care Dying Neurotoxicology
spellingShingle	Medicine and disease in relation to psychology Terminal care Dying Neurotoxicology Adam, Nor Fatini The role of toxoplasma gondii (Tg) in schizophrenia: serofrequency and serointensity of Tg / Nor Fatini Adam
description	Infection with Toxoplasma gondii (Tg) in the central nervous system causes behavioural, personality changes and psychotic symptoms mimicking schizophrenia, a psychiatric illness with unknown aetiology. The aim of this study was to determine the seroprevalence, serointensity of Tg IgG, IgM antibodies and Tg DNA in patients with Schizophrenia and its relationship with demographic profile and clinical factors. This was a cross-sectional study examining the role of Tg in patients with Schizophrenia attending the Sg Buloh Hospital and University Malaya Medical Centre (UMMC) during a period from July 2010 to December 2012. A total of 156 subjects consisting of 57 patients with chronic Schizophrenia, 44 acute Schizophrenia and 55 healthy individuals participated in this study. The demographic profiles, risks and clinical factors were examined to determine the positivity and intensity of Tg IgG, IgM antibodies and Tg DNA. The seropositivity and serointensity of Tg antibodies were measured using Enzyme Linked Immunosorbent Assay (ELISA) while positivity and intensity Tg DNA were measured using Real Time PCR. The seropositivity of IgG antibody were significantly higher in all Schizophrenia, remission and acute Schizophrenia patients than control (p<0.001). The serointensity of IgG antibody were also significantly higher in all Schizophrenia, remission and acute Schizophrenia patients than control (p<0.05). The positivity of DNA Tg were also significantly higher in all Schizophrenia, remission and acute schizophrenia than control (p<0.05).The intensity of Tg DNA were also significantly higher in all Schizophrenia,remission and acute Schizophrenia patients than control (p<0.05). This study suggests that Tg has a significant role in Schizophrenia.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Adam, Nor Fatini
author_facet	Adam, Nor Fatini
author_sort	Adam, Nor Fatini
title	The role of toxoplasma gondii (Tg) in schizophrenia: serofrequency and serointensity of Tg / Nor Fatini Adam
title_short	The role of toxoplasma gondii (Tg) in schizophrenia: serofrequency and serointensity of Tg / Nor Fatini Adam
title_full	The role of toxoplasma gondii (Tg) in schizophrenia: serofrequency and serointensity of Tg / Nor Fatini Adam
title_fullStr	The role of toxoplasma gondii (Tg) in schizophrenia: serofrequency and serointensity of Tg / Nor Fatini Adam
title_full_unstemmed	The role of toxoplasma gondii (Tg) in schizophrenia: serofrequency and serointensity of Tg / Nor Fatini Adam
title_sort	role of toxoplasma gondii (tg) in schizophrenia: serofrequency and serointensity of tg / nor fatini adam
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Medicine
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/16005/1/TM_NOR%20FATINI%20ADAM%20MD%2015_5.PDF
_version_	1783733475464970240

The role of toxoplasma gondii (Tg) in schizophrenia: serofrequency and serointensity of Tg / Nor Fatini Adam

Similar Items