Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri

Shorea macroptera from family Dipterocarpaceae was studied for its phytochemical and biological activities. Eight compounds have been isolated including two compounds in mixture which consists of nine resveratrol oligomers and an isoferrulic derivative. The compounds were identified as (^-pentacosyl...

Full description

Saved in:

Bibliographic Details
Main Author:	Mohd Nazri, Nur Ainaa Atikah
Format:	Thesis
Language:	English
Published:	2014
Online Access:	https://ir.uitm.edu.my/id/eprint/16397/1/TM_NUR%20AINAA%20ATIKAH%20MOHD%20NAZRI%20AS%2014_5.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.16397
record_format	uketd_dc
spelling	my-uitm-ir.163972022-03-23T02:45:17Z Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri 2014 Mohd Nazri, Nur Ainaa Atikah Shorea macroptera from family Dipterocarpaceae was studied for its phytochemical and biological activities. Eight compounds have been isolated including two compounds in mixture which consists of nine resveratrol oligomers and an isoferrulic derivative. The compounds were identified as (^-pentacosyl 3-(3-hydroxy-4-methoxyphenyl) acrylate, E-viniferin, davidiol A, hemsleyanol D, hopeaphenol A, hopeaphenol, isohopeaphenol, stenophyllol B, gnetol and laevifonol. Gnetol is a monomer resveratrol, £- viniferin and laevifonol are dimer resveratrols, davidiol A and stenophyllol B are trimer resveratrols while hemsleyanol D, hopeaphenol A, hopeaphenol and isohopeaphenol are tetramer resveratrols. Structural elucidation was performed with the aid of spectroscopic methods such as ultraviolet (UV), infrared (IR), mass spectrometry (MS), ID and 2D nuclear magnetic resonance (NMR). Shorea macroptera extract and some of the isolated compounds have been tested for antioxidant, antibacterial and also cytotoxic activities. Shorea macroptera extract showed good antioxidant and antibacterial activities compared to individual isolated compounds, e-viniferin demonstrated marked cytotoxic activity which strongly inhibited HL-60 cell lines but moderately on HeLa cell lines. Davidiol A showed significant cytotoxic activities. It strongly inhibited HL-60 cell lines but moderately inhibited HeLa cell line. Hemsleyanol D moderately inhibited the growth of HeLa cell line. Hopeaphenol displayed significant free radical scavenging activity. Stenophyllol B was found active in free radical scavenging and cytotoxic activities. Stenophyllol B exhibited moderate free radical activity and moderately inhibited HL-60 cell lines and HeLa cell lines. However, laevifonol was inactive towards all three assay tested. 2014 Thesis https://ir.uitm.edu.my/id/eprint/16397/ https://ir.uitm.edu.my/id/eprint/16397/1/TM_NUR%20AINAA%20ATIKAH%20MOHD%20NAZRI%20AS%2014_5.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Applied Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
description	Shorea macroptera from family Dipterocarpaceae was studied for its phytochemical and biological activities. Eight compounds have been isolated including two compounds in mixture which consists of nine resveratrol oligomers and an isoferrulic derivative. The compounds were identified as (^-pentacosyl 3-(3-hydroxy-4-methoxyphenyl) acrylate, E-viniferin, davidiol A, hemsleyanol D, hopeaphenol A, hopeaphenol, isohopeaphenol, stenophyllol B, gnetol and laevifonol. Gnetol is a monomer resveratrol, £- viniferin and laevifonol are dimer resveratrols, davidiol A and stenophyllol B are trimer resveratrols while hemsleyanol D, hopeaphenol A, hopeaphenol and isohopeaphenol are tetramer resveratrols. Structural elucidation was performed with the aid of spectroscopic methods such as ultraviolet (UV), infrared (IR), mass spectrometry (MS), ID and 2D nuclear magnetic resonance (NMR). Shorea macroptera extract and some of the isolated compounds have been tested for antioxidant, antibacterial and also cytotoxic activities. Shorea macroptera extract showed good antioxidant and antibacterial activities compared to individual isolated compounds, e-viniferin demonstrated marked cytotoxic activity which strongly inhibited HL-60 cell lines but moderately on HeLa cell lines. Davidiol A showed significant cytotoxic activities. It strongly inhibited HL-60 cell lines but moderately inhibited HeLa cell line. Hemsleyanol D moderately inhibited the growth of HeLa cell line. Hopeaphenol displayed significant free radical scavenging activity. Stenophyllol B was found active in free radical scavenging and cytotoxic activities. Stenophyllol B exhibited moderate free radical activity and moderately inhibited HL-60 cell lines and HeLa cell lines. However, laevifonol was inactive towards all three assay tested.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Mohd Nazri, Nur Ainaa Atikah
spellingShingle	Mohd Nazri, Nur Ainaa Atikah Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
author_facet	Mohd Nazri, Nur Ainaa Atikah
author_sort	Mohd Nazri, Nur Ainaa Atikah
title	Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_short	Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_full	Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_fullStr	Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_full_unstemmed	Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri
title_sort	phytochemical study and bio activity from the stem bark of shore a macroptera dyer / nur ainaa atikah mohd nazri
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Applied Sciences
publishDate	2014
url	https://ir.uitm.edu.my/id/eprint/16397/1/TM_NUR%20AINAA%20ATIKAH%20MOHD%20NAZRI%20AS%2014_5.pdf
_version_	1783733520958488576

Phytochemical study and bio activity from the stem bark of Shore a macroptera dyer / Nur Ainaa Atikah Mohd Nazri

Similar Items