The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf

Chronic stress has been identified as the major pathophysiological etiology for numerous of diseases. One of the underlying detrimental mechanism induced by stress is caused by oxidative stress. The redox imbalanced due to oxidative stress is found to be reversible by the action of antioxidant. The...

Full description

Saved in:

Bibliographic Details
Main Author:	Abdul Manaf, Mohd Hadzrul Hisham
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RB Pathology TP Chemical technology
Online Access:	https://ir.uitm.edu.my/id/eprint/17768/2/17768.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.17768
record_format	uketd_dc
spelling	my-uitm-ir.177682022-11-22T04:39:04Z The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf 2016 Abdul Manaf, Mohd Hadzrul Hisham RB Pathology TP Chemical technology Chronic stress has been identified as the major pathophysiological etiology for numerous of diseases. One of the underlying detrimental mechanism induced by stress is caused by oxidative stress. The redox imbalanced due to oxidative stress is found to be reversible by the action of antioxidant. The present study focused on the effect of Cosmos caudatus (C. caudatus) towards biological stress markers. Male Sprague-Dawley rats were randomly divided into 5 groups, treated with methanolic extract of C. caudatus leaves (100 & 200 mg/kg), quercetin (100 & 200 mg/kg) and saline (control) respectively for 21 days prior and throughout the 13 days of experiment. The rats were then subjected to forced swimming stress and bloods were withdrawn at 6 different days (Basal, Day 1 and every 2 days continuously). The blood analysis revealed that treatment with C. caudatus able to reduce plasma corticosterone level significantly (p<0.005) compared to the control group, reduced plasma malondialdehyde level (p<0.005) and increased plasma total antioxidant capacity level (p<0.005) in the rats following stress exposure. C. caudatus was also found to have a preservation effect on the plasma dehydroepiandrosterone-sulphate level by inhibiting the fluctuation (increment and reduction) in its level following stress exposure. Based on these observations, it is concluded that C. caudatus act as an anti-stress agent through the action of antioxidant activities in modulating stress response mechanisms and serve as a protective agent towards the pathological effect induced by stress. 2016 Thesis https://ir.uitm.edu.my/id/eprint/17768/ https://ir.uitm.edu.my/id/eprint/17768/2/17768.pdf text en public mphil masters Universiti Teknologi MARA (UiTM) Faculty of Medicine Che Bakar, Osman
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Che Bakar, Osman
topic	RB Pathology TP Chemical technology
spellingShingle	RB Pathology TP Chemical technology Abdul Manaf, Mohd Hadzrul Hisham The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
description	Chronic stress has been identified as the major pathophysiological etiology for numerous of diseases. One of the underlying detrimental mechanism induced by stress is caused by oxidative stress. The redox imbalanced due to oxidative stress is found to be reversible by the action of antioxidant. The present study focused on the effect of Cosmos caudatus (C. caudatus) towards biological stress markers. Male Sprague-Dawley rats were randomly divided into 5 groups, treated with methanolic extract of C. caudatus leaves (100 & 200 mg/kg), quercetin (100 & 200 mg/kg) and saline (control) respectively for 21 days prior and throughout the 13 days of experiment. The rats were then subjected to forced swimming stress and bloods were withdrawn at 6 different days (Basal, Day 1 and every 2 days continuously). The blood analysis revealed that treatment with C. caudatus able to reduce plasma corticosterone level significantly (p<0.005) compared to the control group, reduced plasma malondialdehyde level (p<0.005) and increased plasma total antioxidant capacity level (p<0.005) in the rats following stress exposure. C. caudatus was also found to have a preservation effect on the plasma dehydroepiandrosterone-sulphate level by inhibiting the fluctuation (increment and reduction) in its level following stress exposure. Based on these observations, it is concluded that C. caudatus act as an anti-stress agent through the action of antioxidant activities in modulating stress response mechanisms and serve as a protective agent towards the pathological effect induced by stress.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Abdul Manaf, Mohd Hadzrul Hisham
author_facet	Abdul Manaf, Mohd Hadzrul Hisham
author_sort	Abdul Manaf, Mohd Hadzrul Hisham
title	The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
title_short	The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
title_full	The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
title_fullStr	The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
title_full_unstemmed	The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf
title_sort	effect of cosmos caudatus on chronic repetitive forced swimming stress / mohd hadzrul hisham abdul manaf
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Medicine
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/17768/2/17768.pdf
_version_	1783733595012071424

The effect of cosmos caudatus on chronic repetitive forced swimming stress / Mohd Hadzrul Hisham Abdul Manaf

Similar Items