Feasibility interaction of acetaminophenol and selected excipients prepared by solid dispersion mixing techniques / Erdyna Wendy Erang

The aim of this study is to investigate the potential of drug excipient interaction by acetaminophenol as active pharmaceutical ingredient (API) and selected excipient(s) of Poloxamer 188, Poloxamer 407 and PVP prepared by solid dispersion techniques. A fast and simple solid dispersion techniques, w...

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Main Author:	Erang, Erdyna Wendy
Format:	Thesis
Language:	English
Published:	2016
Online Access:	https://ir.uitm.edu.my/id/eprint/17887/2/TM_ERDYNA%20WENDY%20ERANG%20AS%2016_5.pdf
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id	my-uitm-ir.17887
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spelling	my-uitm-ir.178872022-04-14T07:42:26Z Feasibility interaction of acetaminophenol and selected excipients prepared by solid dispersion mixing techniques / Erdyna Wendy Erang 2016-04 Erang, Erdyna Wendy The aim of this study is to investigate the potential of drug excipient interaction by acetaminophenol as active pharmaceutical ingredient (API) and selected excipient(s) of Poloxamer 188, Poloxamer 407 and PVP prepared by solid dispersion techniques. A fast and simple solid dispersion techniques, which are fusion and solvent method were used to prepare the acetaminophenol and selected excipient(s) in three different ratio as follows; 1:1, 1:3 and 3:1. The prepared solid dispersion was then undergoes physicochemical characterization by Attenuated Total Reflection (ATR-FTIR), Differential Scanning Calorimetric (DSC) and Powder X-ray Diffraction (PXRD). Analysis by ATR-FTIR showed that the acetaminophenol and selected excipient(s) prepared by both fusion method show interaction resulting in hydrogen bonding interaction. The PXRD analysis, changes in acetaminophenol crystalline structure was observed by the shifted and changes in peak intensity while DSC showed that no chemical interaction was involved by the acetaminophenol and selected excipient(s) prepared by fusion and solvent method. The results showed that 1:1 ratio was the best ratio in giving the maximum interaction. As a conclusion, the physicochemical caharacterization acetaminophenol and selected excipient(s) by ATR-FTIR, PXRD and DSC has resulted in physical interaction. 2016-04 Thesis https://ir.uitm.edu.my/id/eprint/17887/ https://ir.uitm.edu.my/id/eprint/17887/2/TM_ERDYNA%20WENDY%20ERANG%20AS%2016_5.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Applied Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
description	The aim of this study is to investigate the potential of drug excipient interaction by acetaminophenol as active pharmaceutical ingredient (API) and selected excipient(s) of Poloxamer 188, Poloxamer 407 and PVP prepared by solid dispersion techniques. A fast and simple solid dispersion techniques, which are fusion and solvent method were used to prepare the acetaminophenol and selected excipient(s) in three different ratio as follows; 1:1, 1:3 and 3:1. The prepared solid dispersion was then undergoes physicochemical characterization by Attenuated Total Reflection (ATR-FTIR), Differential Scanning Calorimetric (DSC) and Powder X-ray Diffraction (PXRD). Analysis by ATR-FTIR showed that the acetaminophenol and selected excipient(s) prepared by both fusion method show interaction resulting in hydrogen bonding interaction. The PXRD analysis, changes in acetaminophenol crystalline structure was observed by the shifted and changes in peak intensity while DSC showed that no chemical interaction was involved by the acetaminophenol and selected excipient(s) prepared by fusion and solvent method. The results showed that 1:1 ratio was the best ratio in giving the maximum interaction. As a conclusion, the physicochemical caharacterization acetaminophenol and selected excipient(s) by ATR-FTIR, PXRD and DSC has resulted in physical interaction.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Erang, Erdyna Wendy
spellingShingle	Erang, Erdyna Wendy Feasibility interaction of acetaminophenol and selected excipients prepared by solid dispersion mixing techniques / Erdyna Wendy Erang
author_facet	Erang, Erdyna Wendy
author_sort	Erang, Erdyna Wendy
title	Feasibility interaction of acetaminophenol and selected excipients prepared by solid dispersion mixing techniques / Erdyna Wendy Erang
title_short	Feasibility interaction of acetaminophenol and selected excipients prepared by solid dispersion mixing techniques / Erdyna Wendy Erang
title_full	Feasibility interaction of acetaminophenol and selected excipients prepared by solid dispersion mixing techniques / Erdyna Wendy Erang
title_fullStr	Feasibility interaction of acetaminophenol and selected excipients prepared by solid dispersion mixing techniques / Erdyna Wendy Erang
title_full_unstemmed	Feasibility interaction of acetaminophenol and selected excipients prepared by solid dispersion mixing techniques / Erdyna Wendy Erang
title_sort	feasibility interaction of acetaminophenol and selected excipients prepared by solid dispersion mixing techniques / erdyna wendy erang
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Applied Sciences
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/17887/2/TM_ERDYNA%20WENDY%20ERANG%20AS%2016_5.pdf
_version_	1783733617462083584

Feasibility interaction of acetaminophenol and selected excipients prepared by solid dispersion mixing techniques / Erdyna Wendy Erang

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