Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli

Atherosclerosis is one of the leading causes of coronary artery disease (CAD). Studies on the cardioprotective activities of tocotrienols (T3) in the absence of alpha tocopherol (TCP) remain obscure. The aim of this study was to evaluate the effects of pure T3 supplementation on lipid lowering, tiss...

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Main Author:	Zulkafli, Nurmazni
Format:	Thesis
Language:	English
Published:	2016
Online Access:	https://ir.uitm.edu.my/id/eprint/17912/2/TM_NURMAZNI%20ZULKAFLI%20MD%2016_5.pdf
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id	my-uitm-ir.17912
record_format	uketd_dc
spelling	my-uitm-ir.179122022-04-14T07:24:03Z Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli 2016-04 Zulkafli, Nurmazni Atherosclerosis is one of the leading causes of coronary artery disease (CAD). Studies on the cardioprotective activities of tocotrienols (T3) in the absence of alpha tocopherol (TCP) remain obscure. The aim of this study was to evaluate the effects of pure T3 supplementation on lipid lowering, tissue endothelial activation and inflammatory biomarkers, and oxidative stress in early and established atherosclerosis rabbit model. Fifteen New Zealand white rabbits were divided into two intervention groups: Al [given 2 months normal diet (ND) and 2 weeks high cholesterol diet (HCD)] and A2 (given 2 months ND and 2 months HCD). Each group was further divided into three groups: T3- 4mg/kg and T3-15mg/kg supplementation groups given pure T3 (delta90%-gammal0%) and placebo. Interventions were given throughout the study. Fasting serum lipids, plasma C-reactive protein and 8-isoprostanes were measured at baseline, 4, 8, 10, 12, 16 weeks… 2016-04 Thesis https://ir.uitm.edu.my/id/eprint/17912/ https://ir.uitm.edu.my/id/eprint/17912/2/TM_NURMAZNI%20ZULKAFLI%20MD%2016_5.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Medicine
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
description	Atherosclerosis is one of the leading causes of coronary artery disease (CAD). Studies on the cardioprotective activities of tocotrienols (T3) in the absence of alpha tocopherol (TCP) remain obscure. The aim of this study was to evaluate the effects of pure T3 supplementation on lipid lowering, tissue endothelial activation and inflammatory biomarkers, and oxidative stress in early and established atherosclerosis rabbit model. Fifteen New Zealand white rabbits were divided into two intervention groups: Al [given 2 months normal diet (ND) and 2 weeks high cholesterol diet (HCD)] and A2 (given 2 months ND and 2 months HCD). Each group was further divided into three groups: T3- 4mg/kg and T3-15mg/kg supplementation groups given pure T3 (delta90%-gammal0%) and placebo. Interventions were given throughout the study. Fasting serum lipids, plasma C-reactive protein and 8-isoprostanes were measured at baseline, 4, 8, 10, 12, 16 weeks…
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Zulkafli, Nurmazni
spellingShingle	Zulkafli, Nurmazni Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
author_facet	Zulkafli, Nurmazni
author_sort	Zulkafli, Nurmazni
title	Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
title_short	Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
title_full	Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
title_fullStr	Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
title_full_unstemmed	Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli
title_sort	effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / nurmazni zulkafli
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Medicine
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/17912/2/TM_NURMAZNI%20ZULKAFLI%20MD%2016_5.pdf
_version_	1783733623280631808

Effects of pure tocotrienols on the status of endothelial activation, inflammation, oxidative stress and plaque stability in the prevention of early and established experimental atherosclerosis / Nurmazni Zulkafli

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