Formation of encapsulated mefenamic acid-beta cyclodextrin and unencapsulated mefenamic acid using electrospray technique / Nurul Karimah Zolkepali

The potential of using electrostatic atomizer or electrospray in producing fine and encapsulated particle of Mefenamic Acid (MA) form I with β-cyclodextrin (βCD) was demonstrated in this study. Encapsulated MA-βCD with a molar ratio of 1:2 was prepared in water-ethanol suspension, followed by the el...

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Main Author:	Zolkepali, Nurul Karimah
Format:	Thesis
Language:	English
Published:	2016
Online Access:	https://ir.uitm.edu.my/id/eprint/17913/2/TM_NURUL%20KARIMAH%20ZOLKEPALI%20EH%2016_5.pdf
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id	my-uitm-ir.17913
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spelling	my-uitm-ir.179132022-04-14T02:24:12Z Formation of encapsulated mefenamic acid-beta cyclodextrin and unencapsulated mefenamic acid using electrospray technique / Nurul Karimah Zolkepali 2016-01 Zolkepali, Nurul Karimah The potential of using electrostatic atomizer or electrospray in producing fine and encapsulated particle of Mefenamic Acid (MA) form I with β-cyclodextrin (βCD) was demonstrated in this study. Encapsulated MA-βCD with a molar ratio of 1:2 was prepared in water-ethanol suspension, followed by the electrospray process to atomize the droplet into fine dried particles. The working distance (WD) between the electrospray needle tip and the substrate were varied from 15 to 25 cm. Using FE-SEM and ImageJ software, the sizes of encapsulated MA-βCD particles were found to decrease from 91±26 to 42±35 nm as the WD increased. The dissolution rate of encapsulated particles of MA-βCD was found to be higher compared to the particles of as-received MA and the unencapsulated MA. The presence of the encapsulated MA-βCD was proven by the DSC result with the disappearance of MA peak after the atomization process. The XRD and FTIR analysis showed that the encapsulation occurred with the existence of new solid phase that was expected from the interaction between MA and βCD at 11.30°, 17.60°, 18.18°, 20.36°, 31.32° (2θ) and the appearance of C=C at wavelength 1513 cm⁻¹ to 1642.26 cm⁻¹. Further analysis by TEM showed the size and morphology of MA- βCD particles when immersed in water and acetone. Encapsulated MA-βCD particles were solubilized in water but suspended as a spherical shape in acetone. 2016-01 Thesis https://ir.uitm.edu.my/id/eprint/17913/ https://ir.uitm.edu.my/id/eprint/17913/2/TM_NURUL%20KARIMAH%20ZOLKEPALI%20EH%2016_5.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Chemical Engineering
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
description	The potential of using electrostatic atomizer or electrospray in producing fine and encapsulated particle of Mefenamic Acid (MA) form I with β-cyclodextrin (βCD) was demonstrated in this study. Encapsulated MA-βCD with a molar ratio of 1:2 was prepared in water-ethanol suspension, followed by the electrospray process to atomize the droplet into fine dried particles. The working distance (WD) between the electrospray needle tip and the substrate were varied from 15 to 25 cm. Using FE-SEM and ImageJ software, the sizes of encapsulated MA-βCD particles were found to decrease from 91±26 to 42±35 nm as the WD increased. The dissolution rate of encapsulated particles of MA-βCD was found to be higher compared to the particles of as-received MA and the unencapsulated MA. The presence of the encapsulated MA-βCD was proven by the DSC result with the disappearance of MA peak after the atomization process. The XRD and FTIR analysis showed that the encapsulation occurred with the existence of new solid phase that was expected from the interaction between MA and βCD at 11.30°, 17.60°, 18.18°, 20.36°, 31.32° (2θ) and the appearance of C=C at wavelength 1513 cm⁻¹ to 1642.26 cm⁻¹. Further analysis by TEM showed the size and morphology of MA- βCD particles when immersed in water and acetone. Encapsulated MA-βCD particles were solubilized in water but suspended as a spherical shape in acetone.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Zolkepali, Nurul Karimah
spellingShingle	Zolkepali, Nurul Karimah Formation of encapsulated mefenamic acid-beta cyclodextrin and unencapsulated mefenamic acid using electrospray technique / Nurul Karimah Zolkepali
author_facet	Zolkepali, Nurul Karimah
author_sort	Zolkepali, Nurul Karimah
title	Formation of encapsulated mefenamic acid-beta cyclodextrin and unencapsulated mefenamic acid using electrospray technique / Nurul Karimah Zolkepali
title_short	Formation of encapsulated mefenamic acid-beta cyclodextrin and unencapsulated mefenamic acid using electrospray technique / Nurul Karimah Zolkepali
title_full	Formation of encapsulated mefenamic acid-beta cyclodextrin and unencapsulated mefenamic acid using electrospray technique / Nurul Karimah Zolkepali
title_fullStr	Formation of encapsulated mefenamic acid-beta cyclodextrin and unencapsulated mefenamic acid using electrospray technique / Nurul Karimah Zolkepali
title_full_unstemmed	Formation of encapsulated mefenamic acid-beta cyclodextrin and unencapsulated mefenamic acid using electrospray technique / Nurul Karimah Zolkepali
title_sort	formation of encapsulated mefenamic acid-beta cyclodextrin and unencapsulated mefenamic acid using electrospray technique / nurul karimah zolkepali
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Chemical Engineering
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/17913/2/TM_NURUL%20KARIMAH%20ZOLKEPALI%20EH%2016_5.pdf
_version_	1783733623520755712

Formation of encapsulated mefenamic acid-beta cyclodextrin and unencapsulated mefenamic acid using electrospray technique / Nurul Karimah Zolkepali

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