Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor

The synthesis and characterization of a series of hydroxamic acid namely benzohydroxamic acid (BHA), salicylhydroxamic acid (SHA) and their complexes with Cu(II), Co(II), V(IV), Zn(II), Fe(II), Ni(II) and Cr(III) are described herein. The characterization of the synthesized ligands and complexes wer...

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Main Author:	Mohd Shotor, Siti Noriah
Format:	Thesis
Language:	English
Published:	2014
Online Access:	https://ir.uitm.edu.my/id/eprint/18371/2/TM_SITI%20NORIAH%20MOHD%20SHOTOR%20AS%2014_5.pdf
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id	my-uitm-ir.18371
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spelling	my-uitm-ir.183712022-03-23T02:59:36Z Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor 2014 Mohd Shotor, Siti Noriah The synthesis and characterization of a series of hydroxamic acid namely benzohydroxamic acid (BHA), salicylhydroxamic acid (SHA) and their complexes with Cu(II), Co(II), V(IV), Zn(II), Fe(II), Ni(II) and Cr(III) are described herein. The characterization of the synthesized ligands and complexes were carried out by means of elemental analysis (C,H,N), ¹H and ¹³C NMR and IR spectroscopy, conductivity, magnetic susceptibility and melting point. Through IR and NMR studies, the synthesized ligands were shown to possess the carbonyl (CO) and hydroxylamine (NH₂-OH) groups, characteristics of hydroxamic acid. It was found that the dominant coordination mode in metal-hydroxamic acid complexes was the O, O ’-bidentate chelates in which the ligands were singly deprotonated (hydroxamato). The coordination through the carbonyl oxygen atom and the deprotonated hydroxy group showed a very stable five-membered chelate was formed. Moreover, depending on pH, two (0,0) bonding modes of the ligands are accessible to a series of metal ions like Cu(II), Cr(III), Zn(II), Fe(II) and VO(IV) where in this case, the synthesis took place in acidic environment which making the O, O-bonding modes were more favorable. 2014 Thesis https://ir.uitm.edu.my/id/eprint/18371/ https://ir.uitm.edu.my/id/eprint/18371/2/TM_SITI%20NORIAH%20MOHD%20SHOTOR%20AS%2014_5.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Applied Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
description	The synthesis and characterization of a series of hydroxamic acid namely benzohydroxamic acid (BHA), salicylhydroxamic acid (SHA) and their complexes with Cu(II), Co(II), V(IV), Zn(II), Fe(II), Ni(II) and Cr(III) are described herein. The characterization of the synthesized ligands and complexes were carried out by means of elemental analysis (C,H,N), ¹H and ¹³C NMR and IR spectroscopy, conductivity, magnetic susceptibility and melting point. Through IR and NMR studies, the synthesized ligands were shown to possess the carbonyl (CO) and hydroxylamine (NH₂-OH) groups, characteristics of hydroxamic acid. It was found that the dominant coordination mode in metal-hydroxamic acid complexes was the O, O ’-bidentate chelates in which the ligands were singly deprotonated (hydroxamato). The coordination through the carbonyl oxygen atom and the deprotonated hydroxy group showed a very stable five-membered chelate was formed. Moreover, depending on pH, two (0,0) bonding modes of the ligands are accessible to a series of metal ions like Cu(II), Cr(III), Zn(II), Fe(II) and VO(IV) where in this case, the synthesis took place in acidic environment which making the O, O-bonding modes were more favorable.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Mohd Shotor, Siti Noriah
spellingShingle	Mohd Shotor, Siti Noriah Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor
author_facet	Mohd Shotor, Siti Noriah
author_sort	Mohd Shotor, Siti Noriah
title	Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor
title_short	Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor
title_full	Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor
title_fullStr	Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor
title_full_unstemmed	Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor
title_sort	hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / siti noriah mohd shotor
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Applied Sciences
publishDate	2014
url	https://ir.uitm.edu.my/id/eprint/18371/2/TM_SITI%20NORIAH%20MOHD%20SHOTOR%20AS%2014_5.pdf
_version_	1783733668677681152

Hydroxamic acid series and their metal complexes: synthesis, characterization, cytotoxicity and neurotoxicity study / Siti Noriah Mohd Shotor

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