Evaluation of polymorphic forms of mefenamic acid crystals from solution: modelling and experimental approach / Asna Nabila Ahmad Zamri

Evaluation of polymorphic forms of mefenamic acid crystals from solution: modelling and experimental approach / Asna Nabila Ahmad Zamri

Mefenamic acid (MA) is an active pharmaceutical drug (API), used widely as an antipyretic analgesic and anti-rheumatic drug. However it is practically insoluble in water, restricting its utility in clinical trials. It exhibits two polymorphs that show different solubility and stability where form II...

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Main Author: Ahmad Zamri, Asna Nabila
Format: Thesis
Language:English
Published: 2016
Online Access:https://ir.uitm.edu.my/id/eprint/18487/2/TM_ASNA%20NABILA%20AHMAD%20ZAMRI%20EH%2016_5.pdf
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spelling my-uitm-ir.184872018-10-11T07:40:08Z Evaluation of polymorphic forms of mefenamic acid crystals from solution: modelling and experimental approach / Asna Nabila Ahmad Zamri 2016 Ahmad Zamri, Asna Nabila Mefenamic acid (MA) is an active pharmaceutical drug (API), used widely as an antipyretic analgesic and anti-rheumatic drug. However it is practically insoluble in water, restricting its utility in clinical trials. It exhibits two polymorphs that show different solubility and stability where form II is more soluble than form I, thus preferable for pharmaceutical production. Hence, it is the objective of this thesis to assess the polymorphic forms of MA crystals produced using crystallization process in different process conditions. Molecular modelling simulation was also done to study the molecular interactions of the crystal in order to increase the level of understanding of the factors affecting the produced crystal. XRPD, DSC and FTIR results reveal that different solvent (acetone and dimethylformamide (DMF)) produces different polymorphic forms; form land form II respectively, with different morphologies. Solubility test was carried out which shows that form II is more soluble than form I. HPLC result reveals that there is small inclusion of solvent in the crystals. The prediction of MA crystal morphology and the effect of solvent on crystal were studied using molecular modelling technique. Predicted morphology reveals similarity with the experimental morphology with low percentage errors of lattice energy between modelling and experimental values (0.07% for form I and 0.72% for form II). Assessment of solvent interaction on MA crystal reveals that both solvents are favorable to attach on the crystal, validating the HPLC result. However, DMF is more favourable to attach on form II than acetone on form I. Detail observations revealthat molecular packing of MA crystal plays an important role in the morphological difference between form I and form II, hence different polymorph, thus explaining the experimental result. 2016 Thesis https://ir.uitm.edu.my/id/eprint/18487/ https://ir.uitm.edu.my/id/eprint/18487/2/TM_ASNA%20NABILA%20AHMAD%20ZAMRI%20EH%2016_5.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Chemical Engineering
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
description Mefenamic acid (MA) is an active pharmaceutical drug (API), used widely as an antipyretic analgesic and anti-rheumatic drug. However it is practically insoluble in water, restricting its utility in clinical trials. It exhibits two polymorphs that show different solubility and stability where form II is more soluble than form I, thus preferable for pharmaceutical production. Hence, it is the objective of this thesis to assess the polymorphic forms of MA crystals produced using crystallization process in different process conditions. Molecular modelling simulation was also done to study the molecular interactions of the crystal in order to increase the level of understanding of the factors affecting the produced crystal. XRPD, DSC and FTIR results reveal that different solvent (acetone and dimethylformamide (DMF)) produces different polymorphic forms; form land form II respectively, with different morphologies. Solubility test was carried out which shows that form II is more soluble than form I. HPLC result reveals that there is small inclusion of solvent in the crystals. The prediction of MA crystal morphology and the effect of solvent on crystal were studied using molecular modelling technique. Predicted morphology reveals similarity with the experimental morphology with low percentage errors of lattice energy between modelling and experimental values (0.07% for form I and 0.72% for form II). Assessment of solvent interaction on MA crystal reveals that both solvents are favorable to attach on the crystal, validating the HPLC result. However, DMF is more favourable to attach on form II than acetone on form I. Detail observations revealthat molecular packing of MA crystal plays an important role in the morphological difference between form I and form II, hence different polymorph, thus explaining the experimental result.
format Thesis
qualification_name Master of Philosophy (M.Phil.)
qualification_level Master's degree
author Ahmad Zamri, Asna Nabila
spellingShingle Ahmad Zamri, Asna Nabila
Evaluation of polymorphic forms of mefenamic acid crystals from solution: modelling and experimental approach / Asna Nabila Ahmad Zamri
author_facet Ahmad Zamri, Asna Nabila
author_sort Ahmad Zamri, Asna Nabila
title Evaluation of polymorphic forms of mefenamic acid crystals from solution: modelling and experimental approach / Asna Nabila Ahmad Zamri
title_short Evaluation of polymorphic forms of mefenamic acid crystals from solution: modelling and experimental approach / Asna Nabila Ahmad Zamri
title_full Evaluation of polymorphic forms of mefenamic acid crystals from solution: modelling and experimental approach / Asna Nabila Ahmad Zamri
title_fullStr Evaluation of polymorphic forms of mefenamic acid crystals from solution: modelling and experimental approach / Asna Nabila Ahmad Zamri
title_full_unstemmed Evaluation of polymorphic forms of mefenamic acid crystals from solution: modelling and experimental approach / Asna Nabila Ahmad Zamri
title_sort evaluation of polymorphic forms of mefenamic acid crystals from solution: modelling and experimental approach / asna nabila ahmad zamri
granting_institution Universiti Teknologi MARA
granting_department Faculty of Chemical Engineering
publishDate 2016
url https://ir.uitm.edu.my/id/eprint/18487/2/TM_ASNA%20NABILA%20AHMAD%20ZAMRI%20EH%2016_5.pdf
_version_ 1783733689019006976

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