$The use of immature reticulocyte fraction as a tool for classification of Anemia / Bakhtiar Zamili Sazali$

The use of immature reticulocyte fraction as a tool for classification of Anemia / Bakhtiar Zamili Sazali

Anemia is a blood disorder and the major source of morbidity which is related to impaired oxygen delivery, decrease exercise tolerance and reduce the quality of life in older adults. It can be characterized based on the routine hematological parameter from full blood count test followed by different...

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Main Author:	Sazali, Bakhtiar Zamili
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Clinical pathology Laboratory technique Examination of the blood
Online Access:	https://ir.uitm.edu.my/id/eprint/20003/1/TB_BAKHTIAR%20ZAMILI%20SAZALI%20HS%2016_5.pdf
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id	my-uitm-ir.20003
record_format	uketd_dc
spelling	my-uitm-ir.200032020-02-22T16:02:19Z The use of immature reticulocyte fraction as a tool for classification of Anemia / Bakhtiar Zamili Sazali 2016 Sazali, Bakhtiar Zamili Clinical pathology. Laboratory technique Examination of the blood Anemia is a blood disorder and the major source of morbidity which is related to impaired oxygen delivery, decrease exercise tolerance and reduce the quality of life in older adults. It can be characterized based on the routine hematological parameter from full blood count test followed by differential diagnosis. However, differential diagnosis incur extra cost and time. The present study aims to look into the possibility of using an additional parameter called immature reticulocyte fraction (IRF) to further refine the classification of anemia prior to differential diagnosis. Data collection performed in Hospital Tengku Ampuan Rahimah (Klang) based on the full blood picture report from November 2015 till December 2015 were analyzed. The data were obtained from four groups of anemia patients consisting of anemia in pregnancy, beta thalassemia, hereditary spherocytosis and iron deficiency anemia. The hematological parameters tested were hemoglobin, total red blood cell, hematocrit, reticulocyte and immature reticulocyte fraction. The correlation between IRF and the other hematological parameters was studied. IRF was correlated to all tested parameters for the beta thalassemia group and do not have any correlation for the group of anemia in pregnancy. Hereditary spherocytosis showed correlation between IRF and red blood cell while iron deficiency anemia showed correlation between IRF and all the hematological parameter except red blood cell. Among the hematological parameter tested, only hemoglobin, hematocrit and red blood cell have significantly different mean value among the anemia group tested. Hence, IRF cannot be used for classification of anemia. Instead, hemoglobin, red blood cell, and hematocrit may have better potential to be used as additional tools for differentiation of the different groups of anemia. 2016 Thesis https://ir.uitm.edu.my/id/eprint/20003/ https://ir.uitm.edu.my/id/eprint/20003/1/TB_BAKHTIAR%20ZAMILI%20SAZALI%20HS%2016_5.pdf text en public other degree Universiti Teknologi MARA, Selangor, Puncak Alam Campus Faculty of Health Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Clinical pathology Laboratory technique Examination of the blood
spellingShingle	Clinical pathology Laboratory technique Examination of the blood Sazali, Bakhtiar Zamili The use of immature reticulocyte fraction as a tool for classification of Anemia / Bakhtiar Zamili Sazali
description	Anemia is a blood disorder and the major source of morbidity which is related to impaired oxygen delivery, decrease exercise tolerance and reduce the quality of life in older adults. It can be characterized based on the routine hematological parameter from full blood count test followed by differential diagnosis. However, differential diagnosis incur extra cost and time. The present study aims to look into the possibility of using an additional parameter called immature reticulocyte fraction (IRF) to further refine the classification of anemia prior to differential diagnosis. Data collection performed in Hospital Tengku Ampuan Rahimah (Klang) based on the full blood picture report from November 2015 till December 2015 were analyzed. The data were obtained from four groups of anemia patients consisting of anemia in pregnancy, beta thalassemia, hereditary spherocytosis and iron deficiency anemia. The hematological parameters tested were hemoglobin, total red blood cell, hematocrit, reticulocyte and immature reticulocyte fraction. The correlation between IRF and the other hematological parameters was studied. IRF was correlated to all tested parameters for the beta thalassemia group and do not have any correlation for the group of anemia in pregnancy. Hereditary spherocytosis showed correlation between IRF and red blood cell while iron deficiency anemia showed correlation between IRF and all the hematological parameter except red blood cell. Among the hematological parameter tested, only hemoglobin, hematocrit and red blood cell have significantly different mean value among the anemia group tested. Hence, IRF cannot be used for classification of anemia. Instead, hemoglobin, red blood cell, and hematocrit may have better potential to be used as additional tools for differentiation of the different groups of anemia.
format	Thesis
qualification_name	other
qualification_level	Bachelor degree
author	Sazali, Bakhtiar Zamili
author_facet	Sazali, Bakhtiar Zamili
author_sort	Sazali, Bakhtiar Zamili
title	The use of immature reticulocyte fraction as a tool for classification of Anemia / Bakhtiar Zamili Sazali
title_short	The use of immature reticulocyte fraction as a tool for classification of Anemia / Bakhtiar Zamili Sazali
title_full	The use of immature reticulocyte fraction as a tool for classification of Anemia / Bakhtiar Zamili Sazali
title_fullStr	The use of immature reticulocyte fraction as a tool for classification of Anemia / Bakhtiar Zamili Sazali
title_full_unstemmed	The use of immature reticulocyte fraction as a tool for classification of Anemia / Bakhtiar Zamili Sazali
title_sort	use of immature reticulocyte fraction as a tool for classification of anemia / bakhtiar zamili sazali
granting_institution	Universiti Teknologi MARA, Selangor, Puncak Alam Campus
granting_department	Faculty of Health Sciences
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/20003/1/TB_BAKHTIAR%20ZAMILI%20SAZALI%20HS%2016_5.pdf
_version_	1783733723421736960

The use of immature reticulocyte fraction as a tool for classification of Anemia / Bakhtiar Zamili Sazali

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