A study on solution chemistry and crystallization behavior of L-alanine in the presence of additives / Muhamad Fitri Othman

Crystallization is one of important purification process especially in pharmaceutical industries. However, the presence of impurities in the solution is known to cause a profound effect on the final crystal product. Increasing the level of understanding on the effect of additives to the solution cry...

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Main Author:	Othman, Muhamad Fitri
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Analytical chemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/20437/3/20437.pdf
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spelling	my-uitm-ir.204372024-05-30T03:14:00Z A study on solution chemistry and crystallization behavior of L-alanine in the presence of additives / Muhamad Fitri Othman 2013 Othman, Muhamad Fitri Analytical chemistry Crystallization is one of important purification process especially in pharmaceutical industries. However, the presence of impurities in the solution is known to cause a profound effect on the final crystal product. Increasing the level of understanding on the effect of additives to the solution crystallization is important. It is the objective of this thesis to investigate the effect of additives on the solution chemistry and the produced crystals. The ability of incorporation of additive on the surface morphology was also assessed through computational technique. The solubility experiment of L-alanine, with L-leucine and glycine as additives to the L-alanine solution were carried out by using isothermal method. Prediction of L-alanine crystal morphology and the likelihood of additives incorporation on selective site of the crystal surface via molecular modelling are also presented. The binary system and ternary systems were found to deviate from the ideal system by negative deviations representing a high solute-solvent interaction. Meanwhile, the results from PXRD and DSC analyses indicate that there is an interaction between additives molecules and host crystal surface through adsorption mechanism and thus promotes the formation of a solid solution. The simulated morphology and the calculated lattice energy reveal small deviation from the experimental data. Thus, Dreiding potential function and Mulliken atomic change are the most suitable set to be used to predict the morphology of L-alanine. Modelling studies of additives incorporation on the L-alanine crystal reveal that both additives have different propensity to incorporate on the selective facet of L-alanine. 2013 Thesis https://ir.uitm.edu.my/id/eprint/20437/ https://ir.uitm.edu.my/id/eprint/20437/3/20437.pdf text en public mphil masters Universiti Teknologi MARA Faculty of Chemical Engineering
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Analytical chemistry
spellingShingle	Analytical chemistry Othman, Muhamad Fitri A study on solution chemistry and crystallization behavior of L-alanine in the presence of additives / Muhamad Fitri Othman
description	Crystallization is one of important purification process especially in pharmaceutical industries. However, the presence of impurities in the solution is known to cause a profound effect on the final crystal product. Increasing the level of understanding on the effect of additives to the solution crystallization is important. It is the objective of this thesis to investigate the effect of additives on the solution chemistry and the produced crystals. The ability of incorporation of additive on the surface morphology was also assessed through computational technique. The solubility experiment of L-alanine, with L-leucine and glycine as additives to the L-alanine solution were carried out by using isothermal method. Prediction of L-alanine crystal morphology and the likelihood of additives incorporation on selective site of the crystal surface via molecular modelling are also presented. The binary system and ternary systems were found to deviate from the ideal system by negative deviations representing a high solute-solvent interaction. Meanwhile, the results from PXRD and DSC analyses indicate that there is an interaction between additives molecules and host crystal surface through adsorption mechanism and thus promotes the formation of a solid solution. The simulated morphology and the calculated lattice energy reveal small deviation from the experimental data. Thus, Dreiding potential function and Mulliken atomic change are the most suitable set to be used to predict the morphology of L-alanine. Modelling studies of additives incorporation on the L-alanine crystal reveal that both additives have different propensity to incorporate on the selective facet of L-alanine.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Othman, Muhamad Fitri
author_facet	Othman, Muhamad Fitri
author_sort	Othman, Muhamad Fitri
title	A study on solution chemistry and crystallization behavior of L-alanine in the presence of additives / Muhamad Fitri Othman
title_short	A study on solution chemistry and crystallization behavior of L-alanine in the presence of additives / Muhamad Fitri Othman
title_full	A study on solution chemistry and crystallization behavior of L-alanine in the presence of additives / Muhamad Fitri Othman
title_fullStr	A study on solution chemistry and crystallization behavior of L-alanine in the presence of additives / Muhamad Fitri Othman
title_full_unstemmed	A study on solution chemistry and crystallization behavior of L-alanine in the presence of additives / Muhamad Fitri Othman
title_sort	study on solution chemistry and crystallization behavior of l-alanine in the presence of additives / muhamad fitri othman
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Chemical Engineering
publishDate	2013
url	https://ir.uitm.edu.my/id/eprint/20437/3/20437.pdf
_version_	1804889581139525632

A study on solution chemistry and crystallization behavior of L-alanine in the presence of additives / Muhamad Fitri Othman

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