Organization of the motor neuron somata of geniohyoid and infrahyoid muscles in the medulla oblongata and spinal cord of rat: A horseradish peroxidase study / Aimi Nadia Razlan

Geniohyoid and infrahyoid muscles are important muscles of the neck because they are involved in the process of swallowing. The organization of their motoneurons has been studied by many investigators in rat and many other experimental animals but their results are not in agreement with each other e...

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Main Author:	Razlan, Aimi Nadia
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Oral and dental medicine Pathology Diseases
Online Access:	https://ir.uitm.edu.my/id/eprint/21575/1/TM_AIMI%20NADIA%20RAZLAN%20DS%2017_5.pdf
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spelling	my-uitm-ir.215752018-09-27T08:11:07Z Organization of the motor neuron somata of geniohyoid and infrahyoid muscles in the medulla oblongata and spinal cord of rat: A horseradish peroxidase study / Aimi Nadia Razlan 2017 Razlan, Aimi Nadia Oral and dental medicine. Pathology. Diseases Geniohyoid and infrahyoid muscles are important muscles of the neck because they are involved in the process of swallowing. The organization of their motoneurons has been studied by many investigators in rat and many other experimental animals but their results are not in agreement with each other even in the same species including rat. This prompted the present investigation. Thirty Sprague-Dawley rats were used in the study. The study was performed in medulla oblongata and upper cervical segments of spinal cord by retrograde transport of horseradish peroxidase (HRP) after its injection into geniohyoid and infrahyoid muscles using tetramethylbenzidine (TMB)- HRP method. The sections were examined to identify HRP-labelled neuron somata. Reconstruction of cell groups containing HRP-labelled neuron somaia was made. HRP-labelled neuron somata were organized as follows on the experimental (right) side: (1) Geniohyoid motoneurons: In rostral two thirds of closed part of medulla oblongata (MO) they were located in the ventral part of the main hypoglossal nucleus; in the caudal third of closed part of MO, they were in ventrolateral subnucleus. At spinomedullary junction (SMJ) they were in dorsomedial part of ventral grey column; a few were also seen scattered on right side of central canal and among the corticospinal fibres after pyramidal decussation. (2) Thyrohyoid motoneurons were found in dorsomedial part of right ventral grey column at SMJ and in dorsomedial column of right ventral grey column at C-l (first cervical segment). (3 & 4) Sternohyoid and sternothyroid motoneurons: At SMJ they were present in the region ventral or ventrolateral to the central canal and in the dorsomedial part of the right ventral grey column. At C-l and rostral half of C-2, they were located in dorsomedial column of right ventral grey column. In caudal half of C-2 and whole length of C-3, they were located in dorsomedial and ventrolateral columns of right ventral grey column. (5) Omohyoid motoneurons: At SMJ, they were observed in dorsomedial part of the right ventral grey column. At C-l, they were observed in the dorsomedial column of right ventral grey column. In C-2 and C-3, they were observed in dorsomedial and ventrolateral columns of right ventral grey column. Our results indicate that the motor neuron somata of geniohyoid muscle were organized in a group located in the medulla oblongata and at the SMJ, whereas, the motor neuron somata of infrahyoid muscles were organized in groups located at the SMJ and the ventral grey column of the cervical spinal cord. 2017 Thesis https://ir.uitm.edu.my/id/eprint/21575/ https://ir.uitm.edu.my/id/eprint/21575/1/TM_AIMI%20NADIA%20RAZLAN%20DS%2017_5.pdf text en public degree Universiti Teknologi MARA Faculty of Dentistry
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Oral and dental medicine Pathology Diseases
spellingShingle	Oral and dental medicine Pathology Diseases Razlan, Aimi Nadia Organization of the motor neuron somata of geniohyoid and infrahyoid muscles in the medulla oblongata and spinal cord of rat: A horseradish peroxidase study / Aimi Nadia Razlan
description	Geniohyoid and infrahyoid muscles are important muscles of the neck because they are involved in the process of swallowing. The organization of their motoneurons has been studied by many investigators in rat and many other experimental animals but their results are not in agreement with each other even in the same species including rat. This prompted the present investigation. Thirty Sprague-Dawley rats were used in the study. The study was performed in medulla oblongata and upper cervical segments of spinal cord by retrograde transport of horseradish peroxidase (HRP) after its injection into geniohyoid and infrahyoid muscles using tetramethylbenzidine (TMB)- HRP method. The sections were examined to identify HRP-labelled neuron somata. Reconstruction of cell groups containing HRP-labelled neuron somaia was made. HRP-labelled neuron somata were organized as follows on the experimental (right) side: (1) Geniohyoid motoneurons: In rostral two thirds of closed part of medulla oblongata (MO) they were located in the ventral part of the main hypoglossal nucleus; in the caudal third of closed part of MO, they were in ventrolateral subnucleus. At spinomedullary junction (SMJ) they were in dorsomedial part of ventral grey column; a few were also seen scattered on right side of central canal and among the corticospinal fibres after pyramidal decussation. (2) Thyrohyoid motoneurons were found in dorsomedial part of right ventral grey column at SMJ and in dorsomedial column of right ventral grey column at C-l (first cervical segment). (3 & 4) Sternohyoid and sternothyroid motoneurons: At SMJ they were present in the region ventral or ventrolateral to the central canal and in the dorsomedial part of the right ventral grey column. At C-l and rostral half of C-2, they were located in dorsomedial column of right ventral grey column. In caudal half of C-2 and whole length of C-3, they were located in dorsomedial and ventrolateral columns of right ventral grey column. (5) Omohyoid motoneurons: At SMJ, they were observed in dorsomedial part of the right ventral grey column. At C-l, they were observed in the dorsomedial column of right ventral grey column. In C-2 and C-3, they were observed in dorsomedial and ventrolateral columns of right ventral grey column. Our results indicate that the motor neuron somata of geniohyoid muscle were organized in a group located in the medulla oblongata and at the SMJ, whereas, the motor neuron somata of infrahyoid muscles were organized in groups located at the SMJ and the ventral grey column of the cervical spinal cord.
format	Thesis
qualification_level	Bachelor degree
author	Razlan, Aimi Nadia
author_facet	Razlan, Aimi Nadia
author_sort	Razlan, Aimi Nadia
title	Organization of the motor neuron somata of geniohyoid and infrahyoid muscles in the medulla oblongata and spinal cord of rat: A horseradish peroxidase study / Aimi Nadia Razlan
title_short	Organization of the motor neuron somata of geniohyoid and infrahyoid muscles in the medulla oblongata and spinal cord of rat: A horseradish peroxidase study / Aimi Nadia Razlan
title_full	Organization of the motor neuron somata of geniohyoid and infrahyoid muscles in the medulla oblongata and spinal cord of rat: A horseradish peroxidase study / Aimi Nadia Razlan
title_fullStr	Organization of the motor neuron somata of geniohyoid and infrahyoid muscles in the medulla oblongata and spinal cord of rat: A horseradish peroxidase study / Aimi Nadia Razlan
title_full_unstemmed	Organization of the motor neuron somata of geniohyoid and infrahyoid muscles in the medulla oblongata and spinal cord of rat: A horseradish peroxidase study / Aimi Nadia Razlan
title_sort	organization of the motor neuron somata of geniohyoid and infrahyoid muscles in the medulla oblongata and spinal cord of rat: a horseradish peroxidase study / aimi nadia razlan
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Dentistry
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/21575/1/TM_AIMI%20NADIA%20RAZLAN%20DS%2017_5.pdf
_version_	1783733755352973312

Organization of the motor neuron somata of geniohyoid and infrahyoid muscles in the medulla oblongata and spinal cord of rat: A horseradish peroxidase study / Aimi Nadia Razlan

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