Effectiveness of tenofovir/emtricitabine versus zidovudine/lamivudine in combination with efavirenz in antiretro viral-naive HIV infected patients / Siti Mahanim Shaik Ismail

Durable suppression of replication of the human immunodeficiency virus (HIV) depends on the use of potent, well-tolerated antiretroviral regimens to which patients can easily adhere. Combination of two NRTIs and one NNRTI is the best first line regimen in treating retroviral disease (RVD) as compare...

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Main Author:	Shaik Ismail, Siti Mahanim
Format:	Thesis
Language:	English
Published:	2015
Subjects:	AIDS HIV infections
Online Access:	https://ir.uitm.edu.my/id/eprint/21863/1/TM_SITI%20MAHANIM%20SHAIK%20ISMAIL%20PH%20B%2015_5.pdf
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id	my-uitm-ir.21863
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spelling	my-uitm-ir.218632023-01-27T03:22:13Z Effectiveness of tenofovir/emtricitabine versus zidovudine/lamivudine in combination with efavirenz in antiretro viral-naive HIV infected patients / Siti Mahanim Shaik Ismail 2015 Shaik Ismail, Siti Mahanim AIDS. HIV infections Durable suppression of replication of the human immunodeficiency virus (HIV) depends on the use of potent, well-tolerated antiretroviral regimens to which patients can easily adhere. Combination of two NRTIs and one NNRTI is the best first line regimen in treating retroviral disease (RVD) as compared to combinations of other groups. Tenofovir and Zidovudine are the two drugs that mostly use as one of NNRTIs in combination with either Lamivudine or Emtricitabine. Review of previous literature had shown that there were conflicting data on the superiority of either regime based on virologic and immunologic response. A local, retrospective observational cohort study was conducted to evaluate the virological response (primary endpoint), immunological response and the safety profile between TDF and AZT regimens. A total of 154 ART-nai've samples from HTAR and HSB were recruited. No statistically significant differences were observed in HIV RNA suppression at 24 weeks and 48 weeks (p = 0.407 and p = 0.521, respectively). Mean difference in CD4 increments were also not significant (p = 0.54, 95% CI -59.97, 31.83 at week 24; p = 0.68, 95% CI -51.41, 33.59 at week 48). However, AZT was found with more adverse events that leads to discontinuation (p-value <0.001). There were two cases of virological failure in TDF group but the association was not significant (p = 0.497). Only education level was identified as predictor of therapy effectiveness. Although there was no significant difference in virological and immunological responses, TDF still has advantage over AZT because of its better safety profile 2015 Thesis https://ir.uitm.edu.my/id/eprint/21863/ https://ir.uitm.edu.my/id/eprint/21863/1/TM_SITI%20MAHANIM%20SHAIK%20ISMAIL%20PH%20B%2015_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	AIDS HIV infections
spellingShingle	AIDS HIV infections Shaik Ismail, Siti Mahanim Effectiveness of tenofovir/emtricitabine versus zidovudine/lamivudine in combination with efavirenz in antiretro viral-naive HIV infected patients / Siti Mahanim Shaik Ismail
description	Durable suppression of replication of the human immunodeficiency virus (HIV) depends on the use of potent, well-tolerated antiretroviral regimens to which patients can easily adhere. Combination of two NRTIs and one NNRTI is the best first line regimen in treating retroviral disease (RVD) as compared to combinations of other groups. Tenofovir and Zidovudine are the two drugs that mostly use as one of NNRTIs in combination with either Lamivudine or Emtricitabine. Review of previous literature had shown that there were conflicting data on the superiority of either regime based on virologic and immunologic response. A local, retrospective observational cohort study was conducted to evaluate the virological response (primary endpoint), immunological response and the safety profile between TDF and AZT regimens. A total of 154 ART-nai've samples from HTAR and HSB were recruited. No statistically significant differences were observed in HIV RNA suppression at 24 weeks and 48 weeks (p = 0.407 and p = 0.521, respectively). Mean difference in CD4 increments were also not significant (p = 0.54, 95% CI -59.97, 31.83 at week 24; p = 0.68, 95% CI -51.41, 33.59 at week 48). However, AZT was found with more adverse events that leads to discontinuation (p-value <0.001). There were two cases of virological failure in TDF group but the association was not significant (p = 0.497). Only education level was identified as predictor of therapy effectiveness. Although there was no significant difference in virological and immunological responses, TDF still has advantage over AZT because of its better safety profile
format	Thesis
qualification_level	Master's degree
author	Shaik Ismail, Siti Mahanim
author_facet	Shaik Ismail, Siti Mahanim
author_sort	Shaik Ismail, Siti Mahanim
title	Effectiveness of tenofovir/emtricitabine versus zidovudine/lamivudine in combination with efavirenz in antiretro viral-naive HIV infected patients / Siti Mahanim Shaik Ismail
title_short	Effectiveness of tenofovir/emtricitabine versus zidovudine/lamivudine in combination with efavirenz in antiretro viral-naive HIV infected patients / Siti Mahanim Shaik Ismail
title_full	Effectiveness of tenofovir/emtricitabine versus zidovudine/lamivudine in combination with efavirenz in antiretro viral-naive HIV infected patients / Siti Mahanim Shaik Ismail
title_fullStr	Effectiveness of tenofovir/emtricitabine versus zidovudine/lamivudine in combination with efavirenz in antiretro viral-naive HIV infected patients / Siti Mahanim Shaik Ismail
title_full_unstemmed	Effectiveness of tenofovir/emtricitabine versus zidovudine/lamivudine in combination with efavirenz in antiretro viral-naive HIV infected patients / Siti Mahanim Shaik Ismail
title_sort	effectiveness of tenofovir/emtricitabine versus zidovudine/lamivudine in combination with efavirenz in antiretro viral-naive hiv infected patients / siti mahanim shaik ismail
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/21863/1/TM_SITI%20MAHANIM%20SHAIK%20ISMAIL%20PH%20B%2015_5.pdf
_version_	1783733781476147200

Effectiveness of tenofovir/emtricitabine versus zidovudine/lamivudine in combination with efavirenz in antiretro viral-naive HIV infected patients / Siti Mahanim Shaik Ismail

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