The timeliness of streptokinase administration and its relationship with in-hospital mortality in acute myocardial infarction patient / Nur Mariana Ayub

The reduction in mortality of acute myocardial infarction (AMI) patients is more striking when fibrinolytic is delivered early. A Malaysian guideline recommends initiation of fibrinolytic therapy in the emergency department (ED) within 30 minutes of arrival. The primary study objective is to determi...

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Main Author:	Ayub, Nur Mariana
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/21877/1/TM_NUR%20MARIANA%20AYUB%20PH%20B%2015_5.pdf
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id	my-uitm-ir.21877
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spelling	my-uitm-ir.218772023-01-27T02:38:19Z The timeliness of streptokinase administration and its relationship with in-hospital mortality in acute myocardial infarction patient / Nur Mariana Ayub 2015 Ayub, Nur Mariana Materia medica Pharmacognosy. Pharmaceutical substances (Plant, animal, and inorganic) The reduction in mortality of acute myocardial infarction (AMI) patients is more striking when fibrinolytic is delivered early. A Malaysian guideline recommends initiation of fibrinolytic therapy in the emergency department (ED) within 30 minutes of arrival. The primary study objective is to determine the timing to streptokinase administration with comparison to the Malaysian guidelines and the relationship of the door-to-needle (DTN) time with in-hospital mortality. The study also examined the risk of bleeding with streptokinase and the contributing factors (day and time of ED arrival) that may affect DTN time. A retrospective study was conducted in Hospital Sultanah Aminah Johor Bahru on AMI patients admitted to the Coronary Care Unit and received streptokinase from ED. The data were taken from the ED admission records from January 2013 till September 2014. A total of 86 patients were enrolled in this study. Only 37.2% of the patients were treated according to guidelines. There was no significant association between DTN time and in-hospital mortality (p=0.292). 12.8% of them had bleeding episodes after receiving streptokinase. Day and time of ED arrival did not significantly affect the DTN time; p=0.778 and p=0.575, respectively. This study found that the timeliness of streptokinase administration was not associated with in-hospital mortality, yet DTN time of ≤30 minutes were achieved in less than half of AMI patients. Patients had mild or moderate bleeding risk after receiving streptokinase. ED staffs give priority to treat AMI patients as the highest acuity patients at all time. 2015 Thesis https://ir.uitm.edu.my/id/eprint/21877/ https://ir.uitm.edu.my/id/eprint/21877/1/TM_NUR%20MARIANA%20AYUB%20PH%20B%2015_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Materia medica Materia medica
spellingShingle	Materia medica Materia medica Ayub, Nur Mariana The timeliness of streptokinase administration and its relationship with in-hospital mortality in acute myocardial infarction patient / Nur Mariana Ayub
description	The reduction in mortality of acute myocardial infarction (AMI) patients is more striking when fibrinolytic is delivered early. A Malaysian guideline recommends initiation of fibrinolytic therapy in the emergency department (ED) within 30 minutes of arrival. The primary study objective is to determine the timing to streptokinase administration with comparison to the Malaysian guidelines and the relationship of the door-to-needle (DTN) time with in-hospital mortality. The study also examined the risk of bleeding with streptokinase and the contributing factors (day and time of ED arrival) that may affect DTN time. A retrospective study was conducted in Hospital Sultanah Aminah Johor Bahru on AMI patients admitted to the Coronary Care Unit and received streptokinase from ED. The data were taken from the ED admission records from January 2013 till September 2014. A total of 86 patients were enrolled in this study. Only 37.2% of the patients were treated according to guidelines. There was no significant association between DTN time and in-hospital mortality (p=0.292). 12.8% of them had bleeding episodes after receiving streptokinase. Day and time of ED arrival did not significantly affect the DTN time; p=0.778 and p=0.575, respectively. This study found that the timeliness of streptokinase administration was not associated with in-hospital mortality, yet DTN time of ≤30 minutes were achieved in less than half of AMI patients. Patients had mild or moderate bleeding risk after receiving streptokinase. ED staffs give priority to treat AMI patients as the highest acuity patients at all time.
format	Thesis
qualification_level	Master's degree
author	Ayub, Nur Mariana
author_facet	Ayub, Nur Mariana
author_sort	Ayub, Nur Mariana
title	The timeliness of streptokinase administration and its relationship with in-hospital mortality in acute myocardial infarction patient / Nur Mariana Ayub
title_short	The timeliness of streptokinase administration and its relationship with in-hospital mortality in acute myocardial infarction patient / Nur Mariana Ayub
title_full	The timeliness of streptokinase administration and its relationship with in-hospital mortality in acute myocardial infarction patient / Nur Mariana Ayub
title_fullStr	The timeliness of streptokinase administration and its relationship with in-hospital mortality in acute myocardial infarction patient / Nur Mariana Ayub
title_full_unstemmed	The timeliness of streptokinase administration and its relationship with in-hospital mortality in acute myocardial infarction patient / Nur Mariana Ayub
title_sort	timeliness of streptokinase administration and its relationship with in-hospital mortality in acute myocardial infarction patient / nur mariana ayub
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/21877/1/TM_NUR%20MARIANA%20AYUB%20PH%20B%2015_5.pdf
_version_	1783733785009848320

The timeliness of streptokinase administration and its relationship with in-hospital mortality in acute myocardial infarction patient / Nur Mariana Ayub

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