Efficacy and safety of warfarin in geriatric patient with nonvalvular atrial fibrillation in Hospital Tuanku Ja’afar Seremban / Aslina Ashaari

Nonvalvular atrial fibrillation patients need long-term oral anticoagulant such as warfarin. Warfarin has a narrow therapeutic index, high potential for interaction with food and drugs and can cause bleeding. Geriatric patients are at risk of bleeding. In this study, the efficacy and safety of wa...

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Main Author:	Ashaari, Aslina
Format:	Thesis
Language:	English
Published:	2017
Subjects:	RS Pharmacy and materia medica Materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/25929/1/TM_ASLINA%20ASHAARI%20PH%2017_5.pdf
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spelling	my-uitm-ir.259292019-10-01T08:56:49Z Efficacy and safety of warfarin in geriatric patient with nonvalvular atrial fibrillation in Hospital Tuanku Ja’afar Seremban / Aslina Ashaari 2017 Ashaari, Aslina RS Pharmacy and materia medica Materia medica Nonvalvular atrial fibrillation patients need long-term oral anticoagulant such as warfarin. Warfarin has a narrow therapeutic index, high potential for interaction with food and drugs and can cause bleeding. Geriatric patients are at risk of bleeding. In this study, the efficacy and safety of warfarin and their relationship with other factors have been studied in geriatric of warfarin clinic. There were 84 patients met the inclusion criteria. Patient's data were retrieved from the hospital medical record, medication therapy adherence clinic form, and hospital computerized system named "Sistem Pengurusan Pesakit" Warfarin therapy is normally presented with the fluctuation of TTR values. TTR values were calculated by Rosendaal and Traditional methods. Data descriptive in this study presented with mean, frequency and percentage when appropriate. Statistical analysis tests used were chi-square, t-test, ANOVA, correlation and regression when appropriate with p-value <0.025 (2 tails) is considered significant. Efficacy is defined as good when TTR>65% and the safety assessment defined as INR>3 which related risk of bleeding. The result showed, in term of efficacy, only 44% achieved TTR >65%.The mean TTR for the one year period was 60.1% ±19.6% (Rosendaal method) and 51.9% ±18.6% (Traditional method). In term of safety, from 1073 INR readings, INR>3 was 17.39% of total INR. There were 8 patients admitted due to over warfarinization which representing 9.4% of total admissions with mean INR 5.4 ± 1.58 while mean weekly dosing was 13.6 mg and mean TTR was 50.6%. There were three predictors of efficacy, number of missed dose, number of concurrent medication and number of visited warfarin clinic (p-value<0.025). In conclusion, a majority of geriatric patients were not achieved efficacy, and a few of them had a risk of bleeding. Thus, in order to increase majority of geriatric patients achieved efficacy and safety of warfarin therapy, more efforts and appropriate strategies are needed. 2017 Thesis https://ir.uitm.edu.my/id/eprint/25929/ https://ir.uitm.edu.my/id/eprint/25929/1/TM_ASLINA%20ASHAARI%20PH%2017_5.pdf text en public masters Universiti Teknologi MARA, Puncak Alam Selangor Faculty of Pharmacy,
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	RS Pharmacy and materia medica Materia medica
spellingShingle	RS Pharmacy and materia medica Materia medica Ashaari, Aslina Efficacy and safety of warfarin in geriatric patient with nonvalvular atrial fibrillation in Hospital Tuanku Ja’afar Seremban / Aslina Ashaari
description	Nonvalvular atrial fibrillation patients need long-term oral anticoagulant such as warfarin. Warfarin has a narrow therapeutic index, high potential for interaction with food and drugs and can cause bleeding. Geriatric patients are at risk of bleeding. In this study, the efficacy and safety of warfarin and their relationship with other factors have been studied in geriatric of warfarin clinic. There were 84 patients met the inclusion criteria. Patient's data were retrieved from the hospital medical record, medication therapy adherence clinic form, and hospital computerized system named "Sistem Pengurusan Pesakit" Warfarin therapy is normally presented with the fluctuation of TTR values. TTR values were calculated by Rosendaal and Traditional methods. Data descriptive in this study presented with mean, frequency and percentage when appropriate. Statistical analysis tests used were chi-square, t-test, ANOVA, correlation and regression when appropriate with p-value <0.025 (2 tails) is considered significant. Efficacy is defined as good when TTR>65% and the safety assessment defined as INR>3 which related risk of bleeding. The result showed, in term of efficacy, only 44% achieved TTR >65%.The mean TTR for the one year period was 60.1% ±19.6% (Rosendaal method) and 51.9% ±18.6% (Traditional method). In term of safety, from 1073 INR readings, INR>3 was 17.39% of total INR. There were 8 patients admitted due to over warfarinization which representing 9.4% of total admissions with mean INR 5.4 ± 1.58 while mean weekly dosing was 13.6 mg and mean TTR was 50.6%. There were three predictors of efficacy, number of missed dose, number of concurrent medication and number of visited warfarin clinic (p-value<0.025). In conclusion, a majority of geriatric patients were not achieved efficacy, and a few of them had a risk of bleeding. Thus, in order to increase majority of geriatric patients achieved efficacy and safety of warfarin therapy, more efforts and appropriate strategies are needed.
format	Thesis
qualification_level	Master's degree
author	Ashaari, Aslina
author_facet	Ashaari, Aslina
author_sort	Ashaari, Aslina
title	Efficacy and safety of warfarin in geriatric patient with nonvalvular atrial fibrillation in Hospital Tuanku Ja’afar Seremban / Aslina Ashaari
title_short	Efficacy and safety of warfarin in geriatric patient with nonvalvular atrial fibrillation in Hospital Tuanku Ja’afar Seremban / Aslina Ashaari
title_full	Efficacy and safety of warfarin in geriatric patient with nonvalvular atrial fibrillation in Hospital Tuanku Ja’afar Seremban / Aslina Ashaari
title_fullStr	Efficacy and safety of warfarin in geriatric patient with nonvalvular atrial fibrillation in Hospital Tuanku Ja’afar Seremban / Aslina Ashaari
title_full_unstemmed	Efficacy and safety of warfarin in geriatric patient with nonvalvular atrial fibrillation in Hospital Tuanku Ja’afar Seremban / Aslina Ashaari
title_sort	efficacy and safety of warfarin in geriatric patient with nonvalvular atrial fibrillation in hospital tuanku ja’afar seremban / aslina ashaari
granting_institution	Universiti Teknologi MARA, Puncak Alam Selangor
granting_department	Faculty of Pharmacy,
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/25929/1/TM_ASLINA%20ASHAARI%20PH%2017_5.pdf
_version_	1783733880171266048

Efficacy and safety of warfarin in geriatric patient with nonvalvular atrial fibrillation in Hospital Tuanku Ja’afar Seremban / Aslina Ashaari

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