Evaluation time in therapeutic range (TTR) of patient in warfarin medication therapy adherence clinic (MTAC) in Hospital Putrajaya / Noor Fadzillah Ariffin

Background: Warfarin is the most commonly used oral anticoagulant and has a narrow therapeutic window therefore requires frequent monitoring to maintain the desired treatment targets. Time in therapeutic range (TTR) usually use to identify the quality of INR control in patient with oral anticoagulan...

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Main Author:	Ariffin, Noor Fadzillah
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Infectious and parasitic diseases Specialties of internal medicine
Online Access:	https://ir.uitm.edu.my/id/eprint/26116/1/TM_NOOR%20FADZILLAH%20ARIFFIN%20PH%2016_5.pdf
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spelling	my-uitm-ir.261162019-10-14T00:31:02Z Evaluation time in therapeutic range (TTR) of patient in warfarin medication therapy adherence clinic (MTAC) in Hospital Putrajaya / Noor Fadzillah Ariffin 2016 Ariffin, Noor Fadzillah Infectious and parasitic diseases Specialties of internal medicine Background: Warfarin is the most commonly used oral anticoagulant and has a narrow therapeutic window therefore requires frequent monitoring to maintain the desired treatment targets. Time in therapeutic range (TTR) usually use to identify the quality of INR control in patient with oral anticoagulant. We examined the status of and factor influence TTR and also bleeding and thromboembolic event in warfarin MTAC patients. Methods: We enrolled 162 patients from warfarin MTAC patients list. Patient‘s data were accessed retrospectively through electronic medical records. TTR was calculated using the linear interpolation technique. Descriptive data were analysed using frequency and percentage. Simple logistic regression was used for univariate analyses. Result: The mean of the individual‘s TTR calculated by using the Rosendaal method was 76%, (SD 18.5%) and only 24% of the INR value was out of the target range. Overall percentage of bleeding event would be 11.7% and percentage of thromboembolic events was only around 0.6%. Overall out of 162 patients, 135 patients show the TTR value is more than 60% and only 27 patients the TTR value less than 60%.TTR was not affected by age, gender, sex, race, indications, duration of warfarin, weekly dose and number of concurrent medication. Missed dose was the only statistical significant predictor of poor TTR value (P < 0.001). In patient with missed dose of warfarin has a 2.2 times more likely of having TTR value less than 60% with 95% confident interval (1.50 to 3.12). Conclusion: TTR is generally high in pharmacist managed clinic patients. The INR value most of time was spent within the target ranges. Thus, reflecting a good INR control in pharmacist managed clinic. 2016 Thesis https://ir.uitm.edu.my/id/eprint/26116/ https://ir.uitm.edu.my/id/eprint/26116/1/TM_NOOR%20FADZILLAH%20ARIFFIN%20PH%2016_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Infectious and parasitic diseases Specialties of internal medicine
spellingShingle	Infectious and parasitic diseases Specialties of internal medicine Ariffin, Noor Fadzillah Evaluation time in therapeutic range (TTR) of patient in warfarin medication therapy adherence clinic (MTAC) in Hospital Putrajaya / Noor Fadzillah Ariffin
description	Background: Warfarin is the most commonly used oral anticoagulant and has a narrow therapeutic window therefore requires frequent monitoring to maintain the desired treatment targets. Time in therapeutic range (TTR) usually use to identify the quality of INR control in patient with oral anticoagulant. We examined the status of and factor influence TTR and also bleeding and thromboembolic event in warfarin MTAC patients. Methods: We enrolled 162 patients from warfarin MTAC patients list. Patient‘s data were accessed retrospectively through electronic medical records. TTR was calculated using the linear interpolation technique. Descriptive data were analysed using frequency and percentage. Simple logistic regression was used for univariate analyses. Result: The mean of the individual‘s TTR calculated by using the Rosendaal method was 76%, (SD 18.5%) and only 24% of the INR value was out of the target range. Overall percentage of bleeding event would be 11.7% and percentage of thromboembolic events was only around 0.6%. Overall out of 162 patients, 135 patients show the TTR value is more than 60% and only 27 patients the TTR value less than 60%.TTR was not affected by age, gender, sex, race, indications, duration of warfarin, weekly dose and number of concurrent medication. Missed dose was the only statistical significant predictor of poor TTR value (P < 0.001). In patient with missed dose of warfarin has a 2.2 times more likely of having TTR value less than 60% with 95% confident interval (1.50 to 3.12). Conclusion: TTR is generally high in pharmacist managed clinic patients. The INR value most of time was spent within the target ranges. Thus, reflecting a good INR control in pharmacist managed clinic.
format	Thesis
qualification_level	Master's degree
author	Ariffin, Noor Fadzillah
author_facet	Ariffin, Noor Fadzillah
author_sort	Ariffin, Noor Fadzillah
title	Evaluation time in therapeutic range (TTR) of patient in warfarin medication therapy adherence clinic (MTAC) in Hospital Putrajaya / Noor Fadzillah Ariffin
title_short	Evaluation time in therapeutic range (TTR) of patient in warfarin medication therapy adherence clinic (MTAC) in Hospital Putrajaya / Noor Fadzillah Ariffin
title_full	Evaluation time in therapeutic range (TTR) of patient in warfarin medication therapy adherence clinic (MTAC) in Hospital Putrajaya / Noor Fadzillah Ariffin
title_fullStr	Evaluation time in therapeutic range (TTR) of patient in warfarin medication therapy adherence clinic (MTAC) in Hospital Putrajaya / Noor Fadzillah Ariffin
title_full_unstemmed	Evaluation time in therapeutic range (TTR) of patient in warfarin medication therapy adherence clinic (MTAC) in Hospital Putrajaya / Noor Fadzillah Ariffin
title_sort	evaluation time in therapeutic range (ttr) of patient in warfarin medication therapy adherence clinic (mtac) in hospital putrajaya / noor fadzillah ariffin
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/26116/1/TM_NOOR%20FADZILLAH%20ARIFFIN%20PH%2016_5.pdf
_version_	1783733884122300416

Evaluation time in therapeutic range (TTR) of patient in warfarin medication therapy adherence clinic (MTAC) in Hospital Putrajaya / Noor Fadzillah Ariffin

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