The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan

Objective: This study was conducted to compare the clinical outcomes between amoxicillin/clavulanate plus doxycycline (AC-D) and amoxicillin/clavulanate plus azithromycin (AC-A) in cardiovascular disease patients. Methods: This was a retrospective medical review study of 282 patients with mild to mo...

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Main Author:	Kasiman @ Kamisan, Norhidayah
Format:	Thesis
Language:	English
Published:	2016
Subjects:	RF Otorhinolaryngology Pharmaceutical dosage forms
Online Access:	https://ir.uitm.edu.my/id/eprint/26119/1/TM_NORHIDAYAH%20KASIMAN%20%40%20KAMISAN%20PH%2016_5.pdf
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id	my-uitm-ir.26119
record_format	uketd_dc
spelling	my-uitm-ir.261192019-11-18T03:46:43Z The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan 2016 Kasiman @ Kamisan, Norhidayah RF Otorhinolaryngology Pharmaceutical dosage forms Objective: This study was conducted to compare the clinical outcomes between amoxicillin/clavulanate plus doxycycline (AC-D) and amoxicillin/clavulanate plus azithromycin (AC-A) in cardiovascular disease patients. Methods: This was a retrospective medical review study of 282 patients with mild to moderate community acquired pneumonia (CAP) admitted in general medical wards, Hospital Sultanah Nora Ismail (HSNI) from January 2014 until August 2015. Patients were divided equally into two groups based on antibiotics received within the first 48 hours of ward admission. Patient demographics, initial laboratory findings, antibiotic therapy, daily vital signs and relevant clinical outcomes were extracted from medical records. Clinical outcomes were compared between two groups of antibiotics by using appropriate statistical tests. Results: Compared to the patients treated with AC-A, those treated with AC-D had similar in time to reach clinical stability (2.32 vs. 2.12 days, p = 0.24), time to switch therapy (3.04 vs. 2.80 days, p = 0.20), hospital LOS (3.15 vs. 2.88 days, p = 0.23), rate of treatment failure (1.4% vs. 2.1%, p = 1.00), number of patients who developed QT prolongation (0% vs. 0.7%, p = 1.00) and early achievement in overall clinical outcomes (64.5% vs. 67.6%, p = 0.58). Conclusions: The use of AC-D in cardiovascular disease patients is non-inferior to AC-A. Based on these findings, the clinical effectiveness of AC-D should be evaluated prospectively. 2016 Thesis https://ir.uitm.edu.my/id/eprint/26119/ https://ir.uitm.edu.my/id/eprint/26119/1/TM_NORHIDAYAH%20KASIMAN%20%40%20KAMISAN%20PH%2016_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	RF Otorhinolaryngology Pharmaceutical dosage forms
spellingShingle	RF Otorhinolaryngology Pharmaceutical dosage forms Kasiman @ Kamisan, Norhidayah The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
description	Objective: This study was conducted to compare the clinical outcomes between amoxicillin/clavulanate plus doxycycline (AC-D) and amoxicillin/clavulanate plus azithromycin (AC-A) in cardiovascular disease patients. Methods: This was a retrospective medical review study of 282 patients with mild to moderate community acquired pneumonia (CAP) admitted in general medical wards, Hospital Sultanah Nora Ismail (HSNI) from January 2014 until August 2015. Patients were divided equally into two groups based on antibiotics received within the first 48 hours of ward admission. Patient demographics, initial laboratory findings, antibiotic therapy, daily vital signs and relevant clinical outcomes were extracted from medical records. Clinical outcomes were compared between two groups of antibiotics by using appropriate statistical tests. Results: Compared to the patients treated with AC-A, those treated with AC-D had similar in time to reach clinical stability (2.32 vs. 2.12 days, p = 0.24), time to switch therapy (3.04 vs. 2.80 days, p = 0.20), hospital LOS (3.15 vs. 2.88 days, p = 0.23), rate of treatment failure (1.4% vs. 2.1%, p = 1.00), number of patients who developed QT prolongation (0% vs. 0.7%, p = 1.00) and early achievement in overall clinical outcomes (64.5% vs. 67.6%, p = 0.58). Conclusions: The use of AC-D in cardiovascular disease patients is non-inferior to AC-A. Based on these findings, the clinical effectiveness of AC-D should be evaluated prospectively.
format	Thesis
qualification_level	Master's degree
author	Kasiman @ Kamisan, Norhidayah
author_facet	Kasiman @ Kamisan, Norhidayah
author_sort	Kasiman @ Kamisan, Norhidayah
title	The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
title_short	The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
title_full	The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
title_fullStr	The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
title_full_unstemmed	The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan
title_sort	clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / norhidayah kasiman @ kamisan
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/26119/1/TM_NORHIDAYAH%20KASIMAN%20%40%20KAMISAN%20PH%2016_5.pdf
_version_	1783733884631908352

The clinical outcomes of amoxicillin/clavulanate plus doxycycline versus amoxicillin/clavulanate plus azithromycin for community acquired pneumonia in cardiovascular disease patients / Norhidayah Kasiman @ Kamisan

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