Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin
Colistin is an old antibiotic which use has been abandoned due to its nephrotoxicity. The rise of multidrug- resistance bacterial infections over the decade has led to the resurgence of colistin use. Since then, researches have taken interest into colistin including the incidence and predictors of c...
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my-uitm-ir.262572019-10-23T08:40:27Z Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin 2016 Kamaludin, Ros Sakinah Examination. Diagnosis. Including radiography Colistin is an old antibiotic which use has been abandoned due to its nephrotoxicity. The rise of multidrug- resistance bacterial infections over the decade has led to the resurgence of colistin use. Since then, researches have taken interest into colistin including the incidence and predictors of colistin- associated acute kidney injury (AKI). Studies in other regions reported a wide range of incidence and multiple predictors of colistin- associated AKI. Since to date there is no such data from local healthcare setting, this retrospective cohort study aimed to determine the incidence and predictors of colistin- associated AKI in a Malaysian tertiary healthcare. 77 adult patients who received intravenous (IV) colistin in Hospital Raja Permaisuri Bainun in 2014 until September 2015 were included in the analysis. The incidence of colistin- associated AKI was 31.2% based on the Risk, Injury, Failure; Loss and End- stage Renal Disease (RIFLE) criteria employed. The predictors of colistin- associated AKI found were the length of hospital stay prior to colistin initiation (OR 1.044, 95% CI 1.004- 1.085; p= 0.03) and mechanical ventilation (OR 3.706, 95% CI 1.062- 12.940; p= 0.04). Study population profile and colistin regimen characteristics were comparable to those demonstrated by previous studies. Drug- event causality assessment using Naranjo Adverse Drug Reaction Scale revealed all of the AKI cases fell into ‘Possible’ category. The reported incidence validates the concern of colistin- associated AKI. Even though the predictors of such event varied, efforts to minimize colistin- associated AKI by controlling the risk factors are consistently warranted. 2016 Thesis https://ir.uitm.edu.my/id/eprint/26257/ https://ir.uitm.edu.my/id/eprint/26257/1/TM_ROS%20SAKINAH%20KAMALUDIN%20PH%2016_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy |
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Examination Diagnosis Including radiography Kamaludin, Ros Sakinah Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin |
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Colistin is an old antibiotic which use has been abandoned due to its nephrotoxicity. The rise of multidrug- resistance bacterial infections over the decade has led to the resurgence of colistin use. Since then, researches have taken interest into colistin including the incidence and predictors of colistin- associated acute kidney injury (AKI). Studies in other regions reported a wide range of incidence and multiple predictors of colistin- associated AKI. Since to date there is no such data from local healthcare setting, this retrospective cohort study aimed to determine the incidence and predictors of colistin- associated AKI in a Malaysian tertiary healthcare. 77 adult patients who received intravenous (IV) colistin in Hospital Raja Permaisuri Bainun in 2014 until September 2015 were included in the analysis. The incidence of colistin- associated AKI was 31.2% based on the Risk, Injury, Failure; Loss and End- stage Renal Disease (RIFLE) criteria employed. The predictors of colistin- associated AKI found were the length of hospital stay prior to colistin initiation (OR 1.044, 95% CI 1.004- 1.085; p= 0.03) and mechanical ventilation (OR 3.706, 95% CI 1.062- 12.940; p= 0.04). Study population profile and colistin regimen characteristics were comparable to those demonstrated by previous studies. Drug- event causality assessment using Naranjo Adverse Drug Reaction Scale revealed all of the AKI cases fell into ‘Possible’ category. The reported incidence validates the concern of colistin- associated AKI. Even though the predictors of such event varied, efforts to minimize colistin- associated AKI by controlling the risk factors are consistently warranted. |
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Thesis |
qualification_level |
Master's degree |
author |
Kamaludin, Ros Sakinah |
author_facet |
Kamaludin, Ros Sakinah |
author_sort |
Kamaludin, Ros Sakinah |
title |
Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin |
title_short |
Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin |
title_full |
Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin |
title_fullStr |
Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin |
title_full_unstemmed |
Incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / Ros Sakinah Kamaludin |
title_sort |
incidence and predictors of acute kidney injury in a tertiary care hospitalized patients receiving intravenous colistin / ros sakinah kamaludin |
granting_institution |
Universiti Teknologi MARA |
granting_department |
Faculty of Pharmacy |
publishDate |
2016 |
url |
https://ir.uitm.edu.my/id/eprint/26257/1/TM_ROS%20SAKINAH%20KAMALUDIN%20PH%2016_5.pdf |
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1783733888402587648 |