Physicochemical efects of lactose microcarrier on inhalation performance of rifampicin in polymeric nanoparticles / Ainne Nabila Noraizaan

This study investigated the effects of size, size distribution, specific surface area, surface roughness, crystallinity, and fine content (< 5 pim fraction) of lactose microcarrier on the pulmonary inhalation profiles of rifampicin encapsulated in polyvinylpyrrolidone nanoparticles (194.77 ± 9.52...

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Main Author:	Noraizaan, Ainne Nabila
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/27060/1/TM_AINNE%20NABILA%20NORAIZAAN%20PH%2016_5.pdf
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id	my-uitm-ir.27060
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spelling	my-uitm-ir.270602020-01-06T01:45:51Z Physicochemical efects of lactose microcarrier on inhalation performance of rifampicin in polymeric nanoparticles / Ainne Nabila Noraizaan 2016 Noraizaan, Ainne Nabila Materia medica This study investigated the effects of size, size distribution, specific surface area, surface roughness, crystallinity, and fine content (< 5 pim fraction) of lactose microcarrier on the pulmonary inhalation profiles of rifampicin encapsulated in polyvinylpyrrolidone nanoparticles (194.77 ± 9.52 ran). The spherical lactose was modified through solvation and reprecipitation processes using aqueous ethanolic solution with different ethanol contents. The reprecipitated lactose had smaller particle size, wider size distribution, larger specific surface area, more elongated shape, smoother surface texture and lower crystallinity than the unprocessed lactose. They contained fine particles of sizes smaller than 5 /an of which none was found in the unprocessed lactose. Cascade impactor and scanning electron microscopy analysis of lactose-nanoparticle blends indicated that unprocessed lactose carried nanoparticles through surface adsorption and pore immersion methods. The small, less crystalline and elongated processed lactose carried nanoparticles through surface adsorption and encapsulation via inter-lactose aggregation. The aggregative tendency of these lactoses increased with reduced size and crystallinity and a increased surface roughness that provided more active sites for particulate interaction. This improved the fine particle dose, fine particle fraction, percent dispersed, percent inhaled of nanoparticles due to their ability to remain attaching to lactose during aerosolization, and detach for deep lung deposition in late time domain unlike those immersed in pores of unprocessed lactose. Overall, a lactose fine content amounting to less than 9 % or more than 12 % was detrimental to aerosolization. Excessive fine reduced nanoparticle attachment. Suboptimal fine content discouraged nanoparticle detachment and deposition. 2016 Thesis https://ir.uitm.edu.my/id/eprint/27060/ https://ir.uitm.edu.my/id/eprint/27060/1/TM_AINNE%20NABILA%20NORAIZAAN%20PH%2016_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Materia medica
spellingShingle	Materia medica Noraizaan, Ainne Nabila Physicochemical efects of lactose microcarrier on inhalation performance of rifampicin in polymeric nanoparticles / Ainne Nabila Noraizaan
description	This study investigated the effects of size, size distribution, specific surface area, surface roughness, crystallinity, and fine content (< 5 pim fraction) of lactose microcarrier on the pulmonary inhalation profiles of rifampicin encapsulated in polyvinylpyrrolidone nanoparticles (194.77 ± 9.52 ran). The spherical lactose was modified through solvation and reprecipitation processes using aqueous ethanolic solution with different ethanol contents. The reprecipitated lactose had smaller particle size, wider size distribution, larger specific surface area, more elongated shape, smoother surface texture and lower crystallinity than the unprocessed lactose. They contained fine particles of sizes smaller than 5 /an of which none was found in the unprocessed lactose. Cascade impactor and scanning electron microscopy analysis of lactose-nanoparticle blends indicated that unprocessed lactose carried nanoparticles through surface adsorption and pore immersion methods. The small, less crystalline and elongated processed lactose carried nanoparticles through surface adsorption and encapsulation via inter-lactose aggregation. The aggregative tendency of these lactoses increased with reduced size and crystallinity and a increased surface roughness that provided more active sites for particulate interaction. This improved the fine particle dose, fine particle fraction, percent dispersed, percent inhaled of nanoparticles due to their ability to remain attaching to lactose during aerosolization, and detach for deep lung deposition in late time domain unlike those immersed in pores of unprocessed lactose. Overall, a lactose fine content amounting to less than 9 % or more than 12 % was detrimental to aerosolization. Excessive fine reduced nanoparticle attachment. Suboptimal fine content discouraged nanoparticle detachment and deposition.
format	Thesis
qualification_level	Master's degree
author	Noraizaan, Ainne Nabila
author_facet	Noraizaan, Ainne Nabila
author_sort	Noraizaan, Ainne Nabila
title	Physicochemical efects of lactose microcarrier on inhalation performance of rifampicin in polymeric nanoparticles / Ainne Nabila Noraizaan
title_short	Physicochemical efects of lactose microcarrier on inhalation performance of rifampicin in polymeric nanoparticles / Ainne Nabila Noraizaan
title_full	Physicochemical efects of lactose microcarrier on inhalation performance of rifampicin in polymeric nanoparticles / Ainne Nabila Noraizaan
title_fullStr	Physicochemical efects of lactose microcarrier on inhalation performance of rifampicin in polymeric nanoparticles / Ainne Nabila Noraizaan
title_full_unstemmed	Physicochemical efects of lactose microcarrier on inhalation performance of rifampicin in polymeric nanoparticles / Ainne Nabila Noraizaan
title_sort	physicochemical efects of lactose microcarrier on inhalation performance of rifampicin in polymeric nanoparticles / ainne nabila noraizaan
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/27060/1/TM_AINNE%20NABILA%20NORAIZAAN%20PH%2016_5.pdf
_version_	1783733922744500224

Physicochemical efects of lactose microcarrier on inhalation performance of rifampicin in polymeric nanoparticles / Ainne Nabila Noraizaan

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