Soluble inflammatory biomarkers and apolipoprotein A1 gene variants in low high density lipoprotein concentration / Nurul Atiqah Mohd Mokhsin

Atherosclerosis leads to coronary artery disease (CAD) is a main cause of death worldwide. Low High density lipoprotein (HDL-c) concentration has been associated with increased inflammation, which causes increase risk of CAD. Nevertheless, inflammatory status of low HDL-c subjects and primary causes...

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Main Author:	Mohd Mokhsin, Nurul Atiqah
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Diseases of the digestive system Gastroenterology
Online Access:	https://ir.uitm.edu.my/id/eprint/27282/1/TM_NURUL%20ATIQAH%20MOHD%20MOKHSIN%20MD%2016_5.pdf
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spelling	my-uitm-ir.272822020-01-15T02:53:52Z Soluble inflammatory biomarkers and apolipoprotein A1 gene variants in low high density lipoprotein concentration / Nurul Atiqah Mohd Mokhsin 2016 Mohd Mokhsin, Nurul Atiqah Diseases of the digestive system. Gastroenterology Atherosclerosis leads to coronary artery disease (CAD) is a main cause of death worldwide. Low High density lipoprotein (HDL-c) concentration has been associated with increased inflammation, which causes increase risk of CAD. Nevertheless, inflammatory status of low HDL-c subjects and primary causes due to variations of the apolipoproteinAl (APOA1) gene involved in HDL-c metabolism have not been extensively studied. Hence, this study compared serum concentration of inflammatory biomarkers [interleukin (IL)-6 and high sensitivity c-reactive protein (hsCRP)] between low HDL-c subjects and matched controls, studied the association between HDL-c and inflammatory biomarkers concentrations, determined if HDL-c is an independent predictor of inflammatory biomarkers, and identified variations of the APOA1 gene in low HDL-c subjects compared with matched controls. This study consisted of two parts; biochemical and genetic association studies. Two hundred and seven (207) low HDL-c subjects and 215 matched controls were recruited in the biochemical study, while 70 low HDL-c subjects and 140 matched controls were included in the genetic association study. Serum and whole blood samples were collected for analysis of biochemical and genetic association studies respectively. The results showed enhanced inflammatory biomarkers in low HDL-c subjects, and inverse association was discovered between HDL-c and inflammatory biomarkers, as well as HDL-c was an independent predictor for IL-6. Furthermore, four variants of APOA1 gene were significantly associated with low HDL-c concentration. In conclusion, low HDL-c concentration is strongly correlated to the enhanced inflammatory biomarkers, whereas APOA1 gene may play an important role in low HDL-c subjects in this study. 2016 Thesis https://ir.uitm.edu.my/id/eprint/27282/ https://ir.uitm.edu.my/id/eprint/27282/1/TM_NURUL%20ATIQAH%20MOHD%20MOKHSIN%20MD%2016_5.pdf text en public masters Universiti Teknologi MARA Faculty of Medicine
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Diseases of the digestive system Gastroenterology
spellingShingle	Diseases of the digestive system Gastroenterology Mohd Mokhsin, Nurul Atiqah Soluble inflammatory biomarkers and apolipoprotein A1 gene variants in low high density lipoprotein concentration / Nurul Atiqah Mohd Mokhsin
description	Atherosclerosis leads to coronary artery disease (CAD) is a main cause of death worldwide. Low High density lipoprotein (HDL-c) concentration has been associated with increased inflammation, which causes increase risk of CAD. Nevertheless, inflammatory status of low HDL-c subjects and primary causes due to variations of the apolipoproteinAl (APOA1) gene involved in HDL-c metabolism have not been extensively studied. Hence, this study compared serum concentration of inflammatory biomarkers [interleukin (IL)-6 and high sensitivity c-reactive protein (hsCRP)] between low HDL-c subjects and matched controls, studied the association between HDL-c and inflammatory biomarkers concentrations, determined if HDL-c is an independent predictor of inflammatory biomarkers, and identified variations of the APOA1 gene in low HDL-c subjects compared with matched controls. This study consisted of two parts; biochemical and genetic association studies. Two hundred and seven (207) low HDL-c subjects and 215 matched controls were recruited in the biochemical study, while 70 low HDL-c subjects and 140 matched controls were included in the genetic association study. Serum and whole blood samples were collected for analysis of biochemical and genetic association studies respectively. The results showed enhanced inflammatory biomarkers in low HDL-c subjects, and inverse association was discovered between HDL-c and inflammatory biomarkers, as well as HDL-c was an independent predictor for IL-6. Furthermore, four variants of APOA1 gene were significantly associated with low HDL-c concentration. In conclusion, low HDL-c concentration is strongly correlated to the enhanced inflammatory biomarkers, whereas APOA1 gene may play an important role in low HDL-c subjects in this study.
format	Thesis
qualification_level	Master's degree
author	Mohd Mokhsin, Nurul Atiqah
author_facet	Mohd Mokhsin, Nurul Atiqah
author_sort	Mohd Mokhsin, Nurul Atiqah
title	Soluble inflammatory biomarkers and apolipoprotein A1 gene variants in low high density lipoprotein concentration / Nurul Atiqah Mohd Mokhsin
title_short	Soluble inflammatory biomarkers and apolipoprotein A1 gene variants in low high density lipoprotein concentration / Nurul Atiqah Mohd Mokhsin
title_full	Soluble inflammatory biomarkers and apolipoprotein A1 gene variants in low high density lipoprotein concentration / Nurul Atiqah Mohd Mokhsin
title_fullStr	Soluble inflammatory biomarkers and apolipoprotein A1 gene variants in low high density lipoprotein concentration / Nurul Atiqah Mohd Mokhsin
title_full_unstemmed	Soluble inflammatory biomarkers and apolipoprotein A1 gene variants in low high density lipoprotein concentration / Nurul Atiqah Mohd Mokhsin
title_sort	soluble inflammatory biomarkers and apolipoprotein a1 gene variants in low high density lipoprotein concentration / nurul atiqah mohd mokhsin
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Medicine
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/27282/1/TM_NURUL%20ATIQAH%20MOHD%20MOKHSIN%20MD%2016_5.pdf
_version_	1783733948851945472

Soluble inflammatory biomarkers and apolipoprotein A1 gene variants in low high density lipoprotein concentration / Nurul Atiqah Mohd Mokhsin

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