Effect of paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Norzeila Sulaiman

Infertility is a biological inability of an individual to conceive and half of the cases are related to male infertility. Tocotrienols, a component of vitamin E, demonstrated the ability to improve the functions of male reproductive system. This study was performed to investigate the anti-infertilit...

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Main Author:	Sulaiman, Norzeila
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Specialties of internal medicine
Online Access:	https://ir.uitm.edu.my/id/eprint/27367/1/TD_NORZEILA%20SULAIMAN%20HS%2015_5.pdf
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id	my-uitm-ir.27367
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spelling	my-uitm-ir.273672020-01-21T03:31:56Z Effect of paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Norzeila Sulaiman 2015 Sulaiman, Norzeila Specialties of internal medicine Examination. Diagnosis. Including radiography Infertility is a biological inability of an individual to conceive and half of the cases are related to male infertility. Tocotrienols, a component of vitamin E, demonstrated the ability to improve the functions of male reproductive system. This study was performed to investigate the anti-infertility effects of Tocotrienol Rich Fractions (TRF) from palm oil extract on male rat model. Fifteen male Wistar rats were randomly divided into 5 groups (n=3). Control negative group (F) was orally administered with distilled water (0.1 ml), control positive group (G) was orally administered with vitamin E-free corn oil (O.1ml) and treated groups were orally administered with three different concentrations of TRF, at a dose of 30 mg/kg (H), 60 mg/kg (I) and 90 mg/kg (J) respectively. After 7 days of acute treatment, the blood of the rats was collected using retro orbital sinus technique for biochemical investigation and hormonal analysis. The rats were sacrificed using cervical dislocation. The sperm were collected from cauda epididymis for analysis. TRF supplementation induced improvement in sperm morphology and motility compared to control negative group (F). In similar manner, TRF also provide positive effects to liver and renal function by reducing blood glucose and bilirubin level. Hormonal analysis demonstrated the ability of TRF to enhance LH production, which enhance spermatogenesis, thus helps in boosting fertility. This study suggested that TRF possesses the potential as anti-infertility agent and beneficial to the renal and liver function. 2015 Thesis https://ir.uitm.edu.my/id/eprint/27367/ https://ir.uitm.edu.my/id/eprint/27367/1/TD_NORZEILA%20SULAIMAN%20HS%2015_5.pdf text en public degree Universiti Teknologi MARA Faculty of Health Science
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Specialties of internal medicine Specialties of internal medicine
spellingShingle	Specialties of internal medicine Specialties of internal medicine Sulaiman, Norzeila Effect of paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Norzeila Sulaiman
description	Infertility is a biological inability of an individual to conceive and half of the cases are related to male infertility. Tocotrienols, a component of vitamin E, demonstrated the ability to improve the functions of male reproductive system. This study was performed to investigate the anti-infertility effects of Tocotrienol Rich Fractions (TRF) from palm oil extract on male rat model. Fifteen male Wistar rats were randomly divided into 5 groups (n=3). Control negative group (F) was orally administered with distilled water (0.1 ml), control positive group (G) was orally administered with vitamin E-free corn oil (O.1ml) and treated groups were orally administered with three different concentrations of TRF, at a dose of 30 mg/kg (H), 60 mg/kg (I) and 90 mg/kg (J) respectively. After 7 days of acute treatment, the blood of the rats was collected using retro orbital sinus technique for biochemical investigation and hormonal analysis. The rats were sacrificed using cervical dislocation. The sperm were collected from cauda epididymis for analysis. TRF supplementation induced improvement in sperm morphology and motility compared to control negative group (F). In similar manner, TRF also provide positive effects to liver and renal function by reducing blood glucose and bilirubin level. Hormonal analysis demonstrated the ability of TRF to enhance LH production, which enhance spermatogenesis, thus helps in boosting fertility. This study suggested that TRF possesses the potential as anti-infertility agent and beneficial to the renal and liver function.
format	Thesis
qualification_level	Bachelor degree
author	Sulaiman, Norzeila
author_facet	Sulaiman, Norzeila
author_sort	Sulaiman, Norzeila
title	Effect of paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Norzeila Sulaiman
title_short	Effect of paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Norzeila Sulaiman
title_full	Effect of paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Norzeila Sulaiman
title_fullStr	Effect of paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Norzeila Sulaiman
title_full_unstemmed	Effect of paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Norzeila Sulaiman
title_sort	effect of paternal supplementation of palm oil (tocotrienol rich fraction) on male fertility / norzeila sulaiman
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Health Science
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/27367/1/TD_NORZEILA%20SULAIMAN%20HS%2015_5.pdf
_version_	1783733958336315392

Effect of paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Norzeila Sulaiman

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