$Effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / Junaidi Abd. Halim$

Effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / Junaidi Abd. Halim

Infertility is a biological inability of an individual to conceive and half of the casas are related to female infertility Palm oil TRF was demonstrated to have potential antioxidant to improve oocytes quality and female reproductive system. This study was performed to investigate the effects of ora...

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Main Author:	Abd. Halim, Junaidi
Format:	Thesis
Language:	English
Published:	2015
Subjects:	RG Gynecology and obstetrics
Online Access:	https://ir.uitm.edu.my/id/eprint/27436/1/TD_JUNAIDI%20ABD.%20HALIM%20HS%2015_5.pdf
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id	my-uitm-ir.27436
record_format	uketd_dc
spelling	my-uitm-ir.274362020-01-17T08:34:52Z Effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / Junaidi Abd. Halim 2015 Abd. Halim, Junaidi RG Gynecology and obstetrics RM Therapeutics. Pharmacology Infertility is a biological inability of an individual to conceive and half of the casas are related to female infertility Palm oil TRF was demonstrated to have potential antioxidant to improve oocytes quality and female reproductive system. This study was performed to investigate the effects of oral supplementation of palm oil TRF on oocyta and reproductive parameter of female rats. Different concentrations of palm oil TRF (30 mg/kg, 60 mg/kg, and 90 mg/kg) were used. Thirty (30) adult female Wistar rats were randomly divided into 5 groups (11:6). Control negative group (61) administrated with distilled water, control positive group (62) was administrated orally with corn oil (as vehicle of palm oil TRF) and treatment groups were administrated orally with palm oil TRF at concentration of 30 mg/kg (G3), 60 mg/kg (G4) and 90 mg/kg (GS). Afier 7 days of treatment, blood collection was performed by rem; orbital sinus for biochemical analysis while oocytes were retrieved from oviducts for oocytes count and COCs grading. Oocytes count and normal COCs were increased in 60 mg/kg treated group (G4) compared to other groups. However, there are no significant differences between groups. Histological finding on ovaries has revealed 60 mg/kg (G4) and 90 mg/kg (GS) groups have significantly different on OSE height compared to other groups. Hepatotoxicity and nephrotoxicity assessments revealed 90 mykg group (GS) demonstrated significantly different between treated groups and control groups. This study was sugguted that palm oil TRF have potential in improving oocytes quality and female reproduction. However, further studies should be carried out on hormonal study, IVM, IVF and pregnancy outcomes to ensure the strong evidence on the effects of oral supplementation of palm oil TRF on female fertility. 2015 Thesis https://ir.uitm.edu.my/id/eprint/27436/ https://ir.uitm.edu.my/id/eprint/27436/1/TD_JUNAIDI%20ABD.%20HALIM%20HS%2015_5.pdf text en public degree Universiti Teknologi MARA Faculty of Health Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	RG Gynecology and obstetrics RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics RG Gynecology and obstetrics Abd. Halim, Junaidi Effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / Junaidi Abd. Halim
description	Infertility is a biological inability of an individual to conceive and half of the casas are related to female infertility Palm oil TRF was demonstrated to have potential antioxidant to improve oocytes quality and female reproductive system. This study was performed to investigate the effects of oral supplementation of palm oil TRF on oocyta and reproductive parameter of female rats. Different concentrations of palm oil TRF (30 mg/kg, 60 mg/kg, and 90 mg/kg) were used. Thirty (30) adult female Wistar rats were randomly divided into 5 groups (11:6). Control negative group (61) administrated with distilled water, control positive group (62) was administrated orally with corn oil (as vehicle of palm oil TRF) and treatment groups were administrated orally with palm oil TRF at concentration of 30 mg/kg (G3), 60 mg/kg (G4) and 90 mg/kg (GS). Afier 7 days of treatment, blood collection was performed by rem; orbital sinus for biochemical analysis while oocytes were retrieved from oviducts for oocytes count and COCs grading. Oocytes count and normal COCs were increased in 60 mg/kg treated group (G4) compared to other groups. However, there are no significant differences between groups. Histological finding on ovaries has revealed 60 mg/kg (G4) and 90 mg/kg (GS) groups have significantly different on OSE height compared to other groups. Hepatotoxicity and nephrotoxicity assessments revealed 90 mykg group (GS) demonstrated significantly different between treated groups and control groups. This study was sugguted that palm oil TRF have potential in improving oocytes quality and female reproduction. However, further studies should be carried out on hormonal study, IVM, IVF and pregnancy outcomes to ensure the strong evidence on the effects of oral supplementation of palm oil TRF on female fertility.
format	Thesis
qualification_level	Bachelor degree
author	Abd. Halim, Junaidi
author_facet	Abd. Halim, Junaidi
author_sort	Abd. Halim, Junaidi
title	Effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / Junaidi Abd. Halim
title_short	Effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / Junaidi Abd. Halim
title_full	Effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / Junaidi Abd. Halim
title_fullStr	Effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / Junaidi Abd. Halim
title_full_unstemmed	Effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / Junaidi Abd. Halim
title_sort	effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / junaidi abd. halim
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Health Sciences
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/27436/1/TD_JUNAIDI%20ABD.%20HALIM%20HS%2015_5.pdf
_version_	1783733965944782848

Effect of oral supplementation of palm oil tocotrienolrich fraction on oocytes and reproductive parameter 0f female rats / Junaidi Abd. Halim

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