Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli

Conventional alginate pellets underwent rapid drug dissolution and failed to exert colon targeting unless subjected to complex coating. This study designed coatless delayed-release oral colon-specific alginate pellets for ulcerative colitis treatment. Alginate pellets, formulated with water-insolubl...

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Main Author:	Md. Ramli, Siti Hajar
Format:	Thesis
Language:	English
Published:	2016
Subjects:	Bacteria
Online Access:	https://ir.uitm.edu.my/id/eprint/27555/1/TM_SITI%20HAJAR%20MD%20RAMLI%20PH%2016_5.pdf
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id	my-uitm-ir.27555
record_format	uketd_dc
spelling	my-uitm-ir.275552022-06-14T07:14:42Z Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli 2016 Md. Ramli, Siti Hajar Bacteria Conventional alginate pellets underwent rapid drug dissolution and failed to exert colon targeting unless subjected to complex coating. This study designed coatless delayed-release oral colon-specific alginate pellets for ulcerative colitis treatment. Alginate pellets, formulated with water-insoluble ethylcellulose and various calcium salts, were prepared using solvent-free melt pelletization technique which prevented reaction between processing materials during agglomeration and allowed such reaction to occur only in dissolution. Combination of acid-soluble calcium carbonate and highly water-soluble calcium acetate did not impart colon-specific characteristics to pellets due to pore formation in fragmented matrices. Combination of moderately water-soluble calcium phosphate and calcium acetate delayed drug release due to rapid alginate crosslinking by soluble calcium from acetate salt followed by sustaining alginate crosslinking by calcium phosphate. The use of 1:3 ethylcellulose-to-alginate enhanced the sustained drug release attribute. The ethylcellulose was able to maintain the pellet integrity without calcium acetate. Using hydrophobic prednisolone as therapeutic, hydrophilic alginate pellets formulated with hydrophobic ethylcellulose and moderately polar calcium phosphate exhibited colon-specific in vitro drug release and in vivo anti-inflammatory action. Coatless oral colon-specific alginate pellets can be designed through optimal formulation with melt pelletization as the processing technology. 2016 Thesis https://ir.uitm.edu.my/id/eprint/27555/ https://ir.uitm.edu.my/id/eprint/27555/1/TM_SITI%20HAJAR%20MD%20RAMLI%20PH%2016_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Bacteria
spellingShingle	Bacteria Md. Ramli, Siti Hajar Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
description	Conventional alginate pellets underwent rapid drug dissolution and failed to exert colon targeting unless subjected to complex coating. This study designed coatless delayed-release oral colon-specific alginate pellets for ulcerative colitis treatment. Alginate pellets, formulated with water-insoluble ethylcellulose and various calcium salts, were prepared using solvent-free melt pelletization technique which prevented reaction between processing materials during agglomeration and allowed such reaction to occur only in dissolution. Combination of acid-soluble calcium carbonate and highly water-soluble calcium acetate did not impart colon-specific characteristics to pellets due to pore formation in fragmented matrices. Combination of moderately water-soluble calcium phosphate and calcium acetate delayed drug release due to rapid alginate crosslinking by soluble calcium from acetate salt followed by sustaining alginate crosslinking by calcium phosphate. The use of 1:3 ethylcellulose-to-alginate enhanced the sustained drug release attribute. The ethylcellulose was able to maintain the pellet integrity without calcium acetate. Using hydrophobic prednisolone as therapeutic, hydrophilic alginate pellets formulated with hydrophobic ethylcellulose and moderately polar calcium phosphate exhibited colon-specific in vitro drug release and in vivo anti-inflammatory action. Coatless oral colon-specific alginate pellets can be designed through optimal formulation with melt pelletization as the processing technology.
format	Thesis
qualification_level	Master's degree
author	Md. Ramli, Siti Hajar
author_facet	Md. Ramli, Siti Hajar
author_sort	Md. Ramli, Siti Hajar
title	Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
title_short	Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
title_full	Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
title_fullStr	Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
title_full_unstemmed	Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli
title_sort	coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / siti hajar md. ramli
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2016
url	https://ir.uitm.edu.my/id/eprint/27555/1/TM_SITI%20HAJAR%20MD%20RAMLI%20PH%2016_5.pdf
_version_	1783733974580854784

Coatless alginate pellets as delayed-release drug carrier for inflammatory bowel disease treatment / Siti Hajar Md. Ramli

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