Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria

The interplay effects of matrix formulations with microwave on drug release were investigated using an agglomerate system. Chitosan spheroids were formulated with stearic acid and/or sodium chloride by extrusion-spheronization technique, and chlorpheniramine maleate as water-soluble model drug. The...

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Main Author:	Zakaria, Zabliza
Format:	Thesis
Language:	English
Published:	2010
Subjects:	Materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/27661/1/TM_ZABLIZA%20ZAKARIA%20PH%2010_5.pdf
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id	my-uitm-ir.27661
record_format	uketd_dc
spelling	my-uitm-ir.276612022-06-14T01:51:00Z Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria 2010 Zakaria, Zabliza Materia medica The interplay effects of matrix formulations with microwave on drug release were investigated using an agglomerate system. Chitosan spheroids were formulated with stearic acid and/or sodium chloride by extrusion-spheronization technique, and chlorpheniramine maleate as water-soluble model drug. The spheroids were treated by microwave at 80 W for 5 to 40 min. The profiles of drug dissolution, drug content, drug-polymer interaction, polymer-polymer interaction, sodium leaching, matrix morphology and integrity were determined. Unlike chitosan matrix prepared by ionotropic gelation method, the retardation of drug release from chitosan spheroids by microwave required a more complex formulation containing both stearic acid and sodium chloride unless a high stearic acid fraction was used. These spheroids demonstrated a high resistance to disintegration during dissolution owing to salt-induced bridging by sodium chloride. In response to microwave, sodium chloride aided stearic acid spread and effected domain interaction via C=O moiety over a matrix with reduced specific surface area thereby reducing drug dissolution. The drug release of spheroids can be retarded by microwave through promoting the layering of hydrophobic stearic acid in a matrix structure sustained by sodium chloride. 2010 Thesis https://ir.uitm.edu.my/id/eprint/27661/ https://ir.uitm.edu.my/id/eprint/27661/1/TM_ZABLIZA%20ZAKARIA%20PH%2010_5.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Materia medica
spellingShingle	Materia medica Zakaria, Zabliza Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
description	The interplay effects of matrix formulations with microwave on drug release were investigated using an agglomerate system. Chitosan spheroids were formulated with stearic acid and/or sodium chloride by extrusion-spheronization technique, and chlorpheniramine maleate as water-soluble model drug. The spheroids were treated by microwave at 80 W for 5 to 40 min. The profiles of drug dissolution, drug content, drug-polymer interaction, polymer-polymer interaction, sodium leaching, matrix morphology and integrity were determined. Unlike chitosan matrix prepared by ionotropic gelation method, the retardation of drug release from chitosan spheroids by microwave required a more complex formulation containing both stearic acid and sodium chloride unless a high stearic acid fraction was used. These spheroids demonstrated a high resistance to disintegration during dissolution owing to salt-induced bridging by sodium chloride. In response to microwave, sodium chloride aided stearic acid spread and effected domain interaction via C=O moiety over a matrix with reduced specific surface area thereby reducing drug dissolution. The drug release of spheroids can be retarded by microwave through promoting the layering of hydrophobic stearic acid in a matrix structure sustained by sodium chloride.
format	Thesis
qualification_level	Master's degree
author	Zakaria, Zabliza
author_facet	Zakaria, Zabliza
author_sort	Zakaria, Zabliza
title	Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
title_short	Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
title_full	Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
title_fullStr	Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
title_full_unstemmed	Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria
title_sort	design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / zabliza zakaria
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2010
url	https://ir.uitm.edu.my/id/eprint/27661/1/TM_ZABLIZA%20ZAKARIA%20PH%2010_5.pdf
_version_	1783733988320346112

Design of controlled-release chitosan spheroids prepared by extrusion-spheronization technique using microwave / Zabliza Zakaria

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