Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib

Tocotrienol Rich fraction (TRF) is composed of tocotrienol isomer that is part of Vitamin E family. This study was performed to investigate the fertility potential and toxicity effects of TRF on male rats. Fifteen (15) adult male Wistar rats were randomly divided into 5 groups (n=3). Control negativ...

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Main Author:	Talib, Noor Arshikin
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Genetics Reproduction
Online Access:	https://ir.uitm.edu.my/id/eprint/28019/1/TD_NOOR%20ARSHIKIN%20TALIB%20HS%2015_5.pdf
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id	my-uitm-ir.28019
record_format	uketd_dc
spelling	my-uitm-ir.280192020-02-07T01:33:21Z Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib 2015 Talib, Noor Arshikin Genetics Reproduction Tocotrienol Rich fraction (TRF) is composed of tocotrienol isomer that is part of Vitamin E family. This study was performed to investigate the fertility potential and toxicity effects of TRF on male rats. Fifteen (15) adult male Wistar rats were randomly divided into 5 groups (n=3). Control negative groups was administered orally with distilled water (F), control positive group (G) groups were administered orally with tocopherol stripped com oil and TRF supplementation at dose of 30 mg/kg (H), 60 mg/kg(I) and 90 mg/kg(J). After 7 days of treatment, blood collection was performed by retro orbital sinus for biochemical analysis while sperm were collected from cauda epididymis for sperm analysis. 60 mg/kg showed the highest level of sperm count among TRF treatment group even though the positive control showed the highest sperm count among all groups. The results also showed normal sperm morphology were significantly increased in treated group (H-J) compared to negative/positive group. Hepatotoxicity assessment revealed significant decreased in ALP group in 30 mg/kg and 60 mg/kg of TRF treated group with control groups but no significant difference in AST, and ALT were found. Renal profile for nephrotoxicity of creatinine and urea level also showed no significant different. Reproductive hormone profile of FSH and LH showed significant difference however testosterone showed no significant different. Nevertheless, histological finding has revealed the improvement of spermatogenesis activity in 30 mg/kg and 60 mg/kg of TRF. This study was suggested that TRF have potential in improving fertility without significant hepatotoxicity and nephrotoxicity effect 2015 Thesis https://ir.uitm.edu.my/id/eprint/28019/ https://ir.uitm.edu.my/id/eprint/28019/1/TD_NOOR%20ARSHIKIN%20TALIB%20HS%2015_5.pdf text en public degree Universiti Teknologi MARA Faculty of Health Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Genetics Reproduction
spellingShingle	Genetics Reproduction Talib, Noor Arshikin Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
description	Tocotrienol Rich fraction (TRF) is composed of tocotrienol isomer that is part of Vitamin E family. This study was performed to investigate the fertility potential and toxicity effects of TRF on male rats. Fifteen (15) adult male Wistar rats were randomly divided into 5 groups (n=3). Control negative groups was administered orally with distilled water (F), control positive group (G) groups were administered orally with tocopherol stripped com oil and TRF supplementation at dose of 30 mg/kg (H), 60 mg/kg(I) and 90 mg/kg(J). After 7 days of treatment, blood collection was performed by retro orbital sinus for biochemical analysis while sperm were collected from cauda epididymis for sperm analysis. 60 mg/kg showed the highest level of sperm count among TRF treatment group even though the positive control showed the highest sperm count among all groups. The results also showed normal sperm morphology were significantly increased in treated group (H-J) compared to negative/positive group. Hepatotoxicity assessment revealed significant decreased in ALP group in 30 mg/kg and 60 mg/kg of TRF treated group with control groups but no significant difference in AST, and ALT were found. Renal profile for nephrotoxicity of creatinine and urea level also showed no significant different. Reproductive hormone profile of FSH and LH showed significant difference however testosterone showed no significant different. Nevertheless, histological finding has revealed the improvement of spermatogenesis activity in 30 mg/kg and 60 mg/kg of TRF. This study was suggested that TRF have potential in improving fertility without significant hepatotoxicity and nephrotoxicity effect
format	Thesis
qualification_level	Bachelor degree
author	Talib, Noor Arshikin
author_facet	Talib, Noor Arshikin
author_sort	Talib, Noor Arshikin
title	Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
title_short	Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
title_full	Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
title_fullStr	Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
title_full_unstemmed	Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib
title_sort	effect on paternal supplementation of palm oil (tocotrienol rich fraction) on male fertility / noor arshikin talib
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Health Sciences
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/28019/1/TD_NOOR%20ARSHIKIN%20TALIB%20HS%2015_5.pdf
_version_	1783734035872219136

Effect on paternal supplementation of palm oil (Tocotrienol Rich Fraction) on male fertility / Noor Arshikin Talib

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