Effects of brucea javanica seed extract on fetal implantation and estrogen and progesterone levels in female ICR mice / Wardah Ismail

Brucea javanica (Buah Makassar) a common herbicious plants in Asia, are widely used in traditional medicine for treating some. However, there is lack of reports with regards to its usage in treating reproductive functions. There is possibility that this herb may affect some reproductive functions. T...

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Main Author:	Ismail, Wardah
Format:	Thesis
Language:	English
Published:	2015
Subjects:	Clinical pathology Laboratory technique
Online Access:	https://ir.uitm.edu.my/id/eprint/28032/1/TD_WARDAH%20ISMAIL%20HS%2015_5.pdf
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id	my-uitm-ir.28032
record_format	uketd_dc
spelling	my-uitm-ir.280322020-02-03T08:21:04Z Effects of brucea javanica seed extract on fetal implantation and estrogen and progesterone levels in female ICR mice / Wardah Ismail 2015 Ismail, Wardah Clinical pathology. Laboratory technique Brucea javanica (Buah Makassar) a common herbicious plants in Asia, are widely used in traditional medicine for treating some. However, there is lack of reports with regards to its usage in treating reproductive functions. There is possibility that this herb may affect some reproductive functions. This research was therefore endeavored to determine the possible effects of Brucea javanica extracted from the seeds on mice implantation function. Concurrently, a hormonal study was also done to determine the level of both gonadal hormones important for reproductive functions, estrogen and progesterone during pregnancy with the treatment with the seed extracts. Thirty-two pregnant female ICR mice were divided into four groups of eight each. Group A was given distilled water as control while groups B, C, and D were given oral daily doses of 500, 800, and 1000 mg/kg body weights of Brucea javanica seed extract respectively. Treatment were done for fourteen days. Observations were made as to determine the physical effects of the treatment. Laparotomy was done at day seventeen of the pregnancy to determine number of fetal implantations. Blood samples were collected determination of the hormones. Results obtained showed no significant changes to the number of fetal implantation to all groups. Similarly, there was no significant change in hormonal levels and no obvious change in the physical attributes of the mice. These findings suggest that Brucea javanica seed extract have no effect in implanted fetuses and seem to be safe to be taken during pregnancy. 2015 Thesis https://ir.uitm.edu.my/id/eprint/28032/ https://ir.uitm.edu.my/id/eprint/28032/1/TD_WARDAH%20ISMAIL%20HS%2015_5.pdf text en public degree Universiti Teknologi MARA Faculty of Health Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	Clinical pathology Laboratory technique
spellingShingle	Clinical pathology Laboratory technique Ismail, Wardah Effects of brucea javanica seed extract on fetal implantation and estrogen and progesterone levels in female ICR mice / Wardah Ismail
description	Brucea javanica (Buah Makassar) a common herbicious plants in Asia, are widely used in traditional medicine for treating some. However, there is lack of reports with regards to its usage in treating reproductive functions. There is possibility that this herb may affect some reproductive functions. This research was therefore endeavored to determine the possible effects of Brucea javanica extracted from the seeds on mice implantation function. Concurrently, a hormonal study was also done to determine the level of both gonadal hormones important for reproductive functions, estrogen and progesterone during pregnancy with the treatment with the seed extracts. Thirty-two pregnant female ICR mice were divided into four groups of eight each. Group A was given distilled water as control while groups B, C, and D were given oral daily doses of 500, 800, and 1000 mg/kg body weights of Brucea javanica seed extract respectively. Treatment were done for fourteen days. Observations were made as to determine the physical effects of the treatment. Laparotomy was done at day seventeen of the pregnancy to determine number of fetal implantations. Blood samples were collected determination of the hormones. Results obtained showed no significant changes to the number of fetal implantation to all groups. Similarly, there was no significant change in hormonal levels and no obvious change in the physical attributes of the mice. These findings suggest that Brucea javanica seed extract have no effect in implanted fetuses and seem to be safe to be taken during pregnancy.
format	Thesis
qualification_level	Bachelor degree
author	Ismail, Wardah
author_facet	Ismail, Wardah
author_sort	Ismail, Wardah
title	Effects of brucea javanica seed extract on fetal implantation and estrogen and progesterone levels in female ICR mice / Wardah Ismail
title_short	Effects of brucea javanica seed extract on fetal implantation and estrogen and progesterone levels in female ICR mice / Wardah Ismail
title_full	Effects of brucea javanica seed extract on fetal implantation and estrogen and progesterone levels in female ICR mice / Wardah Ismail
title_fullStr	Effects of brucea javanica seed extract on fetal implantation and estrogen and progesterone levels in female ICR mice / Wardah Ismail
title_full_unstemmed	Effects of brucea javanica seed extract on fetal implantation and estrogen and progesterone levels in female ICR mice / Wardah Ismail
title_sort	effects of brucea javanica seed extract on fetal implantation and estrogen and progesterone levels in female icr mice / wardah ismail
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Health Sciences
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/28032/1/TD_WARDAH%20ISMAIL%20HS%2015_5.pdf
_version_	1783734039139581952

Effects of brucea javanica seed extract on fetal implantation and estrogen and progesterone levels in female ICR mice / Wardah Ismail

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