Toxic properties of iron oxide nanoparticles functionalized with citric acid as a new radiographic contrast enhancer / Nornaizie Che Nor Din

Engineered nanoparticles have been extensively explored in various biomedical settings including nanoparticulate imaging agents due to its promising benefits to mankind. Iodine-intolerance patients have caused alarming concerns in searching new contrast media with lower toxicity effect. However, pro...

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Main Author:	Che Nor Din, Nornaizie
Format:	Thesis
Language:	English
Published:	2015
Subjects:	RM Therapeutics Pharmacology
Online Access:	https://ir.uitm.edu.my/id/eprint/28056/1/TD_NORNAIZIE%20CHE%20NOR%20DIN%20HS%2015_5.pdf
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id	my-uitm-ir.28056
record_format	uketd_dc
spelling	my-uitm-ir.280562020-01-31T07:57:03Z Toxic properties of iron oxide nanoparticles functionalized with citric acid as a new radiographic contrast enhancer / Nornaizie Che Nor Din 2015 Che Nor Din, Nornaizie RM Therapeutics. Pharmacology Engineered nanoparticles have been extensively explored in various biomedical settings including nanoparticulate imaging agents due to its promising benefits to mankind. Iodine-intolerance patients have caused alarming concerns in searching new contrast media with lower toxicity effect. However, proper potential mechanism of nanoparticles has yet to be fully established despite its early acceptance and emerging usage. By using animal model system, our aim is to assess acute nanotoxicity of 14 nm iron oxide nanoparticles (IONPs) coated with citric acid in comparison to iodine. 18 male Wistar Rats were used in order to explore the underlying toxicity of IONPs in liver tissues. .OH free radicals were elucidated by using reactive oxygen species (ROS) production assay and western blotting for the presence of p53 protein expression. The results revealed coated IONPs produced higher ROS level compared to iodine, however no statistical significant were observed. It can be hypothesized that higher amount of antioxidant has been produced by rats in iodine group in correlation to combat higher amount of ROS produced before assayed was conducted. Stronger expressions of the p53 protein from the coated IONPS groups were further observed. Expression of p53 protein suggested initiation of antioxidants production by the protein to ameliorate intracellular ROS production to further achieve normal redox balance in curtailing further damage. The outcomes highlighted that short-term administration of IONPs with functionalization surfaces are safe to be applied as radiographic contrast enhancer. NANOTOXICITY ASSESSMENT OF IRON OXIDE NANOPARTICLES 2015 Thesis https://ir.uitm.edu.my/id/eprint/28056/ https://ir.uitm.edu.my/id/eprint/28056/1/TD_NORNAIZIE%20CHE%20NOR%20DIN%20HS%2015_5.pdf text en public degree Universiti Teknologi MARA Faculty of Health Sciences
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
topic	RM Therapeutics Pharmacology
spellingShingle	RM Therapeutics Pharmacology Che Nor Din, Nornaizie Toxic properties of iron oxide nanoparticles functionalized with citric acid as a new radiographic contrast enhancer / Nornaizie Che Nor Din
description	Engineered nanoparticles have been extensively explored in various biomedical settings including nanoparticulate imaging agents due to its promising benefits to mankind. Iodine-intolerance patients have caused alarming concerns in searching new contrast media with lower toxicity effect. However, proper potential mechanism of nanoparticles has yet to be fully established despite its early acceptance and emerging usage. By using animal model system, our aim is to assess acute nanotoxicity of 14 nm iron oxide nanoparticles (IONPs) coated with citric acid in comparison to iodine. 18 male Wistar Rats were used in order to explore the underlying toxicity of IONPs in liver tissues. .OH free radicals were elucidated by using reactive oxygen species (ROS) production assay and western blotting for the presence of p53 protein expression. The results revealed coated IONPs produced higher ROS level compared to iodine, however no statistical significant were observed. It can be hypothesized that higher amount of antioxidant has been produced by rats in iodine group in correlation to combat higher amount of ROS produced before assayed was conducted. Stronger expressions of the p53 protein from the coated IONPS groups were further observed. Expression of p53 protein suggested initiation of antioxidants production by the protein to ameliorate intracellular ROS production to further achieve normal redox balance in curtailing further damage. The outcomes highlighted that short-term administration of IONPs with functionalization surfaces are safe to be applied as radiographic contrast enhancer. NANOTOXICITY ASSESSMENT OF IRON OXIDE NANOPARTICLES
format	Thesis
qualification_level	Bachelor degree
author	Che Nor Din, Nornaizie
author_facet	Che Nor Din, Nornaizie
author_sort	Che Nor Din, Nornaizie
title	Toxic properties of iron oxide nanoparticles functionalized with citric acid as a new radiographic contrast enhancer / Nornaizie Che Nor Din
title_short	Toxic properties of iron oxide nanoparticles functionalized with citric acid as a new radiographic contrast enhancer / Nornaizie Che Nor Din
title_full	Toxic properties of iron oxide nanoparticles functionalized with citric acid as a new radiographic contrast enhancer / Nornaizie Che Nor Din
title_fullStr	Toxic properties of iron oxide nanoparticles functionalized with citric acid as a new radiographic contrast enhancer / Nornaizie Che Nor Din
title_full_unstemmed	Toxic properties of iron oxide nanoparticles functionalized with citric acid as a new radiographic contrast enhancer / Nornaizie Che Nor Din
title_sort	toxic properties of iron oxide nanoparticles functionalized with citric acid as a new radiographic contrast enhancer / nornaizie che nor din
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Health Sciences
publishDate	2015
url	https://ir.uitm.edu.my/id/eprint/28056/1/TD_NORNAIZIE%20CHE%20NOR%20DIN%20HS%2015_5.pdf
_version_	1783734045275848704

Toxic properties of iron oxide nanoparticles functionalized with citric acid as a new radiographic contrast enhancer / Nornaizie Che Nor Din

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