Screening of cognitive dysfunction in outpatients with major depressive disorder and its associated factors in Hospital Selayang / Husni Zaim Ab Latiff

Background: Major Depressive Disorder (MDD) is a significant mental health problem worldwide. Cognitive dysfunction (CD) is frequently observed both during acute episode and as residual symptom of MDD. It as a predominant symptom of MDD, contributing to impairment of social and occupational function...

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Main Author:	Ab Latiff, Husni Zaim
Format:	Thesis
Language:	English
Published:	2019
Subjects:	Dementia
Online Access:	https://ir.uitm.edu.my/id/eprint/29728/1/29728.pdf
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id	my-uitm-ir.29728
record_format	uketd_dc
spelling	my-uitm-ir.297282022-07-15T07:38:48Z Screening of cognitive dysfunction in outpatients with major depressive disorder and its associated factors in Hospital Selayang / Husni Zaim Ab Latiff 2019-10 Ab Latiff, Husni Zaim Dementia Depression. Affective disorders Background: Major Depressive Disorder (MDD) is a significant mental health problem worldwide. Cognitive dysfunction (CD) is frequently observed both during acute episode and as residual symptom of MDD. It as a predominant symptom of MDD, contributing to impairment of social and occupational functioning. Objective: General objective of this study was to assess and describe CD amongst adult patients with MDD under psychiatric clinic follow up at Hospital Selayang. Specific objectives were to determine the prevalence of CD among MDD in study population, to compare the sociodemographic and clinical profiles, to determine the domains of cognition mostly affected and the factor(s) associated with CD among study population. Methodology: This was a cross-sectional study involving MDD patients attending psychiatric clinic in Hospital Selayang, who were recruited through systematic random sampling. Those who fulfilled the selection criteria and gave informed consent were selected. Sociodemographic data was obtained from the patients. Clinical data was obtained from clinical notes. Confirmation of MDD was done using Mini International Neuropsychiatric Interview (M.I.N.I 7.0). Screening for CD was done using Montreal Cognitive Assessment (MoCA). Descriptive analysis was performed, followed by univariate analysis and multiple logistic regression analysis. Results: Of the total 245 participants, 32.7% (n=80, 95% CI: 26.7, 38.6) patients with MDD had CD. From multiple logistic regression, presence of CD amongst MDD patient was significantly associated with secondary education level and lower (OR: 6.09; 95% CI: 2.82, 13.16; p<0.001), five or more depressive episodes (OR: 8.93; 95% CI: 3.24, 24.67; p<0.001), treatment non-compliance (OR: 3.48; 95% CI: 1.40, 6.59; p=0.003), and presence of medical comorbidity (OR: 2.74; 95% CI: 1.46, 5.18; p=0.002). Conclusion: CD is prevalent among patients with MDD in Hospital Selayang. Having low education level, five or more episodes of depression, treatment non-compliance, and medical comorbidity strongly associated to CD amongst MDD patients. Hence, clinician need to be cognisant of CD and its associated factors in the treatment of the MDD patients. Its routine assessment possibly warranted in clinical setting. 2019-10 Thesis https://ir.uitm.edu.my/id/eprint/29728/ https://ir.uitm.edu.my/id/eprint/29728/1/29728.pdf text en public masters Universiti Teknologi MARA (Kampus Sg. Buloh) Faculty of Medicine Ariaratnam, Suthahar Shuib, Norley Isa, Mohamad Rodi
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Ariaratnam, Suthahar Shuib, Norley Isa, Mohamad Rodi
topic	Dementia Dementia
spellingShingle	Dementia Dementia Ab Latiff, Husni Zaim Screening of cognitive dysfunction in outpatients with major depressive disorder and its associated factors in Hospital Selayang / Husni Zaim Ab Latiff
description	Background: Major Depressive Disorder (MDD) is a significant mental health problem worldwide. Cognitive dysfunction (CD) is frequently observed both during acute episode and as residual symptom of MDD. It as a predominant symptom of MDD, contributing to impairment of social and occupational functioning. Objective: General objective of this study was to assess and describe CD amongst adult patients with MDD under psychiatric clinic follow up at Hospital Selayang. Specific objectives were to determine the prevalence of CD among MDD in study population, to compare the sociodemographic and clinical profiles, to determine the domains of cognition mostly affected and the factor(s) associated with CD among study population. Methodology: This was a cross-sectional study involving MDD patients attending psychiatric clinic in Hospital Selayang, who were recruited through systematic random sampling. Those who fulfilled the selection criteria and gave informed consent were selected. Sociodemographic data was obtained from the patients. Clinical data was obtained from clinical notes. Confirmation of MDD was done using Mini International Neuropsychiatric Interview (M.I.N.I 7.0). Screening for CD was done using Montreal Cognitive Assessment (MoCA). Descriptive analysis was performed, followed by univariate analysis and multiple logistic regression analysis. Results: Of the total 245 participants, 32.7% (n=80, 95% CI: 26.7, 38.6) patients with MDD had CD. From multiple logistic regression, presence of CD amongst MDD patient was significantly associated with secondary education level and lower (OR: 6.09; 95% CI: 2.82, 13.16; p<0.001), five or more depressive episodes (OR: 8.93; 95% CI: 3.24, 24.67; p<0.001), treatment non-compliance (OR: 3.48; 95% CI: 1.40, 6.59; p=0.003), and presence of medical comorbidity (OR: 2.74; 95% CI: 1.46, 5.18; p=0.002). Conclusion: CD is prevalent among patients with MDD in Hospital Selayang. Having low education level, five or more episodes of depression, treatment non-compliance, and medical comorbidity strongly associated to CD amongst MDD patients. Hence, clinician need to be cognisant of CD and its associated factors in the treatment of the MDD patients. Its routine assessment possibly warranted in clinical setting.
format	Thesis
qualification_level	Master's degree
author	Ab Latiff, Husni Zaim
author_facet	Ab Latiff, Husni Zaim
author_sort	Ab Latiff, Husni Zaim
title	Screening of cognitive dysfunction in outpatients with major depressive disorder and its associated factors in Hospital Selayang / Husni Zaim Ab Latiff
title_short	Screening of cognitive dysfunction in outpatients with major depressive disorder and its associated factors in Hospital Selayang / Husni Zaim Ab Latiff
title_full	Screening of cognitive dysfunction in outpatients with major depressive disorder and its associated factors in Hospital Selayang / Husni Zaim Ab Latiff
title_fullStr	Screening of cognitive dysfunction in outpatients with major depressive disorder and its associated factors in Hospital Selayang / Husni Zaim Ab Latiff
title_full_unstemmed	Screening of cognitive dysfunction in outpatients with major depressive disorder and its associated factors in Hospital Selayang / Husni Zaim Ab Latiff
title_sort	screening of cognitive dysfunction in outpatients with major depressive disorder and its associated factors in hospital selayang / husni zaim ab latiff
granting_institution	Universiti Teknologi MARA (Kampus Sg. Buloh)
granting_department	Faculty of Medicine
publishDate	2019
url	https://ir.uitm.edu.my/id/eprint/29728/1/29728.pdf
_version_	1783734078772609024

Screening of cognitive dysfunction in outpatients with major depressive disorder and its associated factors in Hospital Selayang / Husni Zaim Ab Latiff

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