Study on the efficacy of sevelamer carbonate versus calcium carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis at Pusat Penyelidikan Klinikal Clinical Research Centre (CRC) Hospital Serdang / Siti Rohaya Daud

Study on the efficacy of sevelamer carbonate versus calcium carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis at Pusat Penyelidikan Klinikal Clinical Research Centre (CRC) Hospital Serdang / Siti Rohaya Daud

Hyperphosphatemia (HyperPO4) and chronic kidney disease are metabolic bone disease that is common in end stage renal disease. Untreated hyperphosphatemia can lead to cardiovascular disease and calciphylaxis. It is a risk factor for cardiovascular disease and independently associated with mortality....

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Main Author: Daud, Siti Rohaya
Format: Thesis
Language:English
Published: 2014
Subjects:
Chronic diseases
Online Access:https://ir.uitm.edu.my/id/eprint/33635/1/33635.pdf
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spelling my-uitm-ir.336352020-08-18T05:54:02Z Study on the efficacy of sevelamer carbonate versus calcium carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis at Pusat Penyelidikan Klinikal Clinical Research Centre (CRC) Hospital Serdang / Siti Rohaya Daud 2014-01 Daud, Siti Rohaya Chronic diseases Hyperphosphatemia (HyperPO4) and chronic kidney disease are metabolic bone disease that is common in end stage renal disease. Untreated hyperphosphatemia can lead to cardiovascular disease and calciphylaxis. It is a risk factor for cardiovascular disease and independently associated with mortality. Calcium based phosphate binders can cause progression in vascular calcification, which is a recognised risk factor for cardiovascular disease in chronic kidney disease patients. Sevelamer is a non calcium-based phosphate binder which has been showed to be effective on controlling hyperphosphatemia and reducing serum phosphorus in patients with chronic kidney disease. 310 patients from Hospital Serdang were screened for eligibility. 114 patients were eligible, 62 patients declined to give informed consent and 5 patients withdrawn consent before randomisation. Approximately fifty two (52) patients were enrolled in this prospective open-labelled crossover trial. This study used a randomized, open-label, crossover design study which compares the efficacy of Sevelamer Carbonate versus Calcium Carbonate in the treatment of hypherphosphatemia in patients with chronic kidney disease on dialysis. Based on the findings, it was found that sevelamer carbonate gives equally significant effective in comparing with calcium carbonate as the treatment of hyperphosphatemia in chronic kidney disease. Sevelamer carbonate can be used in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis 2014-01 Thesis https://ir.uitm.edu.my/id/eprint/33635/ https://ir.uitm.edu.my/id/eprint/33635/1/33635.pdf text en public degree Universiti Teknologi MARA Cawangan Kelantan Faculty of Computer and Mathematical Sciences Wan Yaacob, Wan Fairos
institution Universiti Teknologi MARA
collection UiTM Institutional Repository
language English
advisor Wan Yaacob, Wan Fairos
topic Chronic diseases
spellingShingle Chronic diseases
Daud, Siti Rohaya
Study on the efficacy of sevelamer carbonate versus calcium carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis at Pusat Penyelidikan Klinikal Clinical Research Centre (CRC) Hospital Serdang / Siti Rohaya Daud
description Hyperphosphatemia (HyperPO4) and chronic kidney disease are metabolic bone disease that is common in end stage renal disease. Untreated hyperphosphatemia can lead to cardiovascular disease and calciphylaxis. It is a risk factor for cardiovascular disease and independently associated with mortality. Calcium based phosphate binders can cause progression in vascular calcification, which is a recognised risk factor for cardiovascular disease in chronic kidney disease patients. Sevelamer is a non calcium-based phosphate binder which has been showed to be effective on controlling hyperphosphatemia and reducing serum phosphorus in patients with chronic kidney disease. 310 patients from Hospital Serdang were screened for eligibility. 114 patients were eligible, 62 patients declined to give informed consent and 5 patients withdrawn consent before randomisation. Approximately fifty two (52) patients were enrolled in this prospective open-labelled crossover trial. This study used a randomized, open-label, crossover design study which compares the efficacy of Sevelamer Carbonate versus Calcium Carbonate in the treatment of hypherphosphatemia in patients with chronic kidney disease on dialysis. Based on the findings, it was found that sevelamer carbonate gives equally significant effective in comparing with calcium carbonate as the treatment of hyperphosphatemia in chronic kidney disease. Sevelamer carbonate can be used in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis
format Thesis
qualification_level Bachelor degree
author Daud, Siti Rohaya
author_facet Daud, Siti Rohaya
author_sort Daud, Siti Rohaya
title Study on the efficacy of sevelamer carbonate versus calcium carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis at Pusat Penyelidikan Klinikal Clinical Research Centre (CRC) Hospital Serdang / Siti Rohaya Daud
title_short Study on the efficacy of sevelamer carbonate versus calcium carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis at Pusat Penyelidikan Klinikal Clinical Research Centre (CRC) Hospital Serdang / Siti Rohaya Daud
title_full Study on the efficacy of sevelamer carbonate versus calcium carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis at Pusat Penyelidikan Klinikal Clinical Research Centre (CRC) Hospital Serdang / Siti Rohaya Daud
title_fullStr Study on the efficacy of sevelamer carbonate versus calcium carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis at Pusat Penyelidikan Klinikal Clinical Research Centre (CRC) Hospital Serdang / Siti Rohaya Daud
title_full_unstemmed Study on the efficacy of sevelamer carbonate versus calcium carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis at Pusat Penyelidikan Klinikal Clinical Research Centre (CRC) Hospital Serdang / Siti Rohaya Daud
title_sort study on the efficacy of sevelamer carbonate versus calcium carbonate in the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis at pusat penyelidikan klinikal clinical research centre (crc) hospital serdang / siti rohaya daud
granting_institution Universiti Teknologi MARA Cawangan Kelantan
granting_department Faculty of Computer and Mathematical Sciences
publishDate 2014
url https://ir.uitm.edu.my/id/eprint/33635/1/33635.pdf
_version_ 1783734247699251200

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