Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari

Several Betulinic acid peptides here synthesized by incorporating BA with neutral amino acids using standard coupling protocols in the presence of HoBt, HBtu and DiPEA. In addition enantiopure betulinic-acid- cyclohexene silyl ether peptides was successly synthesized in a good yield. Futher olefinic...

Full description

Saved in:

Bibliographic Details
Main Author:	Zahari, Habsah
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Indexes (General) Biochemistry
Online Access:	https://ir.uitm.edu.my/id/eprint/37162/1/37162.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-uitm-ir.37162
record_format	uketd_dc
spelling	my-uitm-ir.371622022-09-26T03:17:38Z Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari 2017 Zahari, Habsah Indexes (General) Biochemistry Peptides. Amino acid sequence Several Betulinic acid peptides here synthesized by incorporating BA with neutral amino acids using standard coupling protocols in the presence of HoBt, HBtu and DiPEA. In addition enantiopure betulinic-acid- cyclohexene silyl ether peptides was successly synthesized in a good yield. Futher olefinic cleavage reaction, afforded betulinic acid -y- butylrolactone peptides, which undergoes benzylation reaction to furnish desired end product benzylated BA-y-butylrolactone product. Five new synthesized betulinic acid derivatives were tested for their in vitro cytotoxicity against human corrected carainoma cell lines ( HT116). The result of preliminary biological activities showed that three compounds betulinic acid-cyclohexene silyl ether peptides, benzylated betulinic acid-alanine peptide, and benzylated betulinic acid-y-butylrolactone peptides with more hydrosolubility compare to betulinic acid, possessed impressive cytotoxicity with the IC50 values of 50.00, 36.67, 25.33 (ug/ml) respectively 2017 Thesis https://ir.uitm.edu.my/id/eprint/37162/ https://ir.uitm.edu.my/id/eprint/37162/1/37162.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Mohd Ali, Mohd Tajudin
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Mohd Ali, Mohd Tajudin
topic	Indexes (General) Biochemistry Indexes (General)
spellingShingle	Indexes (General) Biochemistry Indexes (General) Zahari, Habsah Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
description	Several Betulinic acid peptides here synthesized by incorporating BA with neutral amino acids using standard coupling protocols in the presence of HoBt, HBtu and DiPEA. In addition enantiopure betulinic-acid- cyclohexene silyl ether peptides was successly synthesized in a good yield. Futher olefinic cleavage reaction, afforded betulinic acid -y- butylrolactone peptides, which undergoes benzylation reaction to furnish desired end product benzylated BA-y-butylrolactone product. Five new synthesized betulinic acid derivatives were tested for their in vitro cytotoxicity against human corrected carainoma cell lines ( HT116). The result of preliminary biological activities showed that three compounds betulinic acid-cyclohexene silyl ether peptides, benzylated betulinic acid-alanine peptide, and benzylated betulinic acid-y-butylrolactone peptides with more hydrosolubility compare to betulinic acid, possessed impressive cytotoxicity with the IC50 values of 50.00, 36.67, 25.33 (ug/ml) respectively
format	Thesis
qualification_level	Master's degree
author	Zahari, Habsah
author_facet	Zahari, Habsah
author_sort	Zahari, Habsah
title	Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
title_short	Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
title_full	Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
title_fullStr	Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
title_full_unstemmed	Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari
title_sort	synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / habsah zahari
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Applied Sciences
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/37162/1/37162.pdf
_version_	1783734392330387456

Synthesis of peptides based on betulinic acid scaffold and betulinic-butyrolactone derivatives / Habsah Zahari

Similar Items