Warfarin anticoagulation and outcomes in patients with atrial fibrillation: a retrospective study on different types of Ministry of Health treatment protocol / Salihah Aidit

Atrial fibrillation (AF) is a common cause of stroke, accounting for approximately 10% to 15% of all ischemic strokes and nearly a quarter of strokes for those older than 80 years. Warfarin is widely used oral anticoagulants for the treatment of AF and reducing the rate of stroke. Warfarin need freq...

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Main Author:	Aidit, Salihah
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Medical centers Hospitals Dispensaries Clinics Drugs and their actions
Online Access:	https://ir.uitm.edu.my/id/eprint/37957/1/37957.pdf
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id	my-uitm-ir.37957
record_format	uketd_dc
spelling	my-uitm-ir.379572022-11-01T08:34:37Z Warfarin anticoagulation and outcomes in patients with atrial fibrillation: a retrospective study on different types of Ministry of Health treatment protocol / Salihah Aidit 2017 Aidit, Salihah Medical centers. Hospitals. Dispensaries. Clinics Drugs and their actions Atrial fibrillation (AF) is a common cause of stroke, accounting for approximately 10% to 15% of all ischemic strokes and nearly a quarter of strokes for those older than 80 years. Warfarin is widely used oral anticoagulants for the treatment of AF and reducing the rate of stroke. Warfarin need frequent international normalized ratio (INR) monitoring and careful titration of warfarin doses. Literature has shown that warfarin therapy monitoring provided by a pharmacist could improve the patients' outcome. The research objective is to evaluate the clinical outcomes of warfarin therapy on different types of MOH treatment protocol. Primary endpoints included the mean time to therapeutic INR, the mean percentage of time in therapeutic range, bleeding events, and common drug interactions. We enrolled 151 patients from new warfarin patients diagnosed with AF. A retrospective, observational study was carried out in Selayang Hospital from 2009 to 2014. The INR and time in therapeutic range (TTR) levels in usual medical care (UMC) group and pharmacist-led warfarin medication therapy adherence clinic (WMTAC) after the implementation of MOH WMTAC protocol were compared. There were significant associations between UMC group and WMTAC group in TTR (p = 0.01) and INR (p = 0.02) levels. There was improvement in the pharmacists' involvement in the WMTAC where the pharmacists' recommendation accepted (p = 0.01) and expanded therapeutic INR range during WMTAC sessions (p = 0.04) were statistically significant higher in WMTAC group. Pharmacist's involvement in the WMTAC group enhances the effectiveness of the MOH Warfarin protocol. 2017 Thesis https://ir.uitm.edu.my/id/eprint/37957/ https://ir.uitm.edu.my/id/eprint/37957/1/37957.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Long, Chiau Ming
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Long, Chiau Ming
topic	Medical centers Hospitals Dispensaries Clinics Drugs and their actions
spellingShingle	Medical centers Hospitals Dispensaries Clinics Drugs and their actions Aidit, Salihah Warfarin anticoagulation and outcomes in patients with atrial fibrillation: a retrospective study on different types of Ministry of Health treatment protocol / Salihah Aidit
description	Atrial fibrillation (AF) is a common cause of stroke, accounting for approximately 10% to 15% of all ischemic strokes and nearly a quarter of strokes for those older than 80 years. Warfarin is widely used oral anticoagulants for the treatment of AF and reducing the rate of stroke. Warfarin need frequent international normalized ratio (INR) monitoring and careful titration of warfarin doses. Literature has shown that warfarin therapy monitoring provided by a pharmacist could improve the patients' outcome. The research objective is to evaluate the clinical outcomes of warfarin therapy on different types of MOH treatment protocol. Primary endpoints included the mean time to therapeutic INR, the mean percentage of time in therapeutic range, bleeding events, and common drug interactions. We enrolled 151 patients from new warfarin patients diagnosed with AF. A retrospective, observational study was carried out in Selayang Hospital from 2009 to 2014. The INR and time in therapeutic range (TTR) levels in usual medical care (UMC) group and pharmacist-led warfarin medication therapy adherence clinic (WMTAC) after the implementation of MOH WMTAC protocol were compared. There were significant associations between UMC group and WMTAC group in TTR (p = 0.01) and INR (p = 0.02) levels. There was improvement in the pharmacists' involvement in the WMTAC where the pharmacists' recommendation accepted (p = 0.01) and expanded therapeutic INR range during WMTAC sessions (p = 0.04) were statistically significant higher in WMTAC group. Pharmacist's involvement in the WMTAC group enhances the effectiveness of the MOH Warfarin protocol.
format	Thesis
qualification_level	Master's degree
author	Aidit, Salihah
author_facet	Aidit, Salihah
author_sort	Aidit, Salihah
title	Warfarin anticoagulation and outcomes in patients with atrial fibrillation: a retrospective study on different types of Ministry of Health treatment protocol / Salihah Aidit
title_short	Warfarin anticoagulation and outcomes in patients with atrial fibrillation: a retrospective study on different types of Ministry of Health treatment protocol / Salihah Aidit
title_full	Warfarin anticoagulation and outcomes in patients with atrial fibrillation: a retrospective study on different types of Ministry of Health treatment protocol / Salihah Aidit
title_fullStr	Warfarin anticoagulation and outcomes in patients with atrial fibrillation: a retrospective study on different types of Ministry of Health treatment protocol / Salihah Aidit
title_full_unstemmed	Warfarin anticoagulation and outcomes in patients with atrial fibrillation: a retrospective study on different types of Ministry of Health treatment protocol / Salihah Aidit
title_sort	warfarin anticoagulation and outcomes in patients with atrial fibrillation: a retrospective study on different types of ministry of health treatment protocol / salihah aidit
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/37957/1/37957.pdf
_version_	1783734444587220992

Warfarin anticoagulation and outcomes in patients with atrial fibrillation: a retrospective study on different types of Ministry of Health treatment protocol / Salihah Aidit

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