Anti-infertility assessments of Ficus deltoidea var. kunstleri ethanolic leaves extract in letrozole-induced polycystic ovarian syndrome rats / Nur Ajeerah Suhaimi

The global prevalence of polycystic ovarian syndrome (PCOS) has reached epidemic proportion contributing to female infertility. Meanwhile, numerous pharmacological properties oiFicus deltoidea {Mas Cotek) have been continuously reported. However, there is limited knowledge pertaining to its effect o...

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Main Author:	Suhaimi, Nur Ajeerah
Format:	Thesis
Language:	English
Published:	2017
Online Access:	https://ir.uitm.edu.my/id/eprint/38025/1/38025.pdf
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id	my-uitm-ir.38025
record_format	uketd_dc
spelling	my-uitm-ir.380252023-01-26T09:03:37Z Anti-infertility assessments of Ficus deltoidea var. kunstleri ethanolic leaves extract in letrozole-induced polycystic ovarian syndrome rats / Nur Ajeerah Suhaimi 2017 Suhaimi, Nur Ajeerah The global prevalence of polycystic ovarian syndrome (PCOS) has reached epidemic proportion contributing to female infertility. Meanwhile, numerous pharmacological properties oiFicus deltoidea {Mas Cotek) have been continuously reported. However, there is limited knowledge pertaining to its effect on PCOS subject. In the study, F. deltoidea var. kunstleri ethanolic leaves extract was evaluated in-vivo to elucidate its effects on oestrous cyclicity, several hormones and histology of reproductive organs among letrozole-induced PCOS female Sprague Dawley. Rats (N=36) were divided into six groups (n=6). Five groups were induced into PCOS, while sixth group was non-PCOS normal control (NC). PCOS induced rats were grouped and treated with: group 1, saline (PC); group 2 (10 mg clomiphene citrate, PCC); and groups 3 (PFD25), 4 (PFD125), 5 (PFD250) with 25,125 and 250 mg/kg of plant extract respectively, for 42 days. Post treatment with F. deltoidea var. kunstleri, PCOS rats showed significantly reduced testosterone and insulin levels (p<0.05), with increased occurrences of oestrus phase and reduced the ovarian weights. The ability of the leaves extract to induce ovulation was evidenced by increasing number of corpus luteum and reducing cystic follicle number observed in ovaries. Meanwhile, uterine thickness and its relative weight were significantly increased. Overall, it was shown that F. deltoidea var. kunstleri leaves exert antiinfertility activities by improving ovulation, rectifying endocrine imbalance and remodelling of ovarian and uterine tissues among letrozole-induced PCOS model. 2017 Thesis https://ir.uitm.edu.my/id/eprint/38025/ https://ir.uitm.edu.my/id/eprint/38025/1/38025.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Applied Sciences Hashim, Nooraain
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Hashim, Nooraain
description	The global prevalence of polycystic ovarian syndrome (PCOS) has reached epidemic proportion contributing to female infertility. Meanwhile, numerous pharmacological properties oiFicus deltoidea {Mas Cotek) have been continuously reported. However, there is limited knowledge pertaining to its effect on PCOS subject. In the study, F. deltoidea var. kunstleri ethanolic leaves extract was evaluated in-vivo to elucidate its effects on oestrous cyclicity, several hormones and histology of reproductive organs among letrozole-induced PCOS female Sprague Dawley. Rats (N=36) were divided into six groups (n=6). Five groups were induced into PCOS, while sixth group was non-PCOS normal control (NC). PCOS induced rats were grouped and treated with: group 1, saline (PC); group 2 (10 mg clomiphene citrate, PCC); and groups 3 (PFD25), 4 (PFD125), 5 (PFD250) with 25,125 and 250 mg/kg of plant extract respectively, for 42 days. Post treatment with F. deltoidea var. kunstleri, PCOS rats showed significantly reduced testosterone and insulin levels (p<0.05), with increased occurrences of oestrus phase and reduced the ovarian weights. The ability of the leaves extract to induce ovulation was evidenced by increasing number of corpus luteum and reducing cystic follicle number observed in ovaries. Meanwhile, uterine thickness and its relative weight were significantly increased. Overall, it was shown that F. deltoidea var. kunstleri leaves exert antiinfertility activities by improving ovulation, rectifying endocrine imbalance and remodelling of ovarian and uterine tissues among letrozole-induced PCOS model.
format	Thesis
qualification_level	Master's degree
author	Suhaimi, Nur Ajeerah
spellingShingle	Suhaimi, Nur Ajeerah Anti-infertility assessments of Ficus deltoidea var. kunstleri ethanolic leaves extract in letrozole-induced polycystic ovarian syndrome rats / Nur Ajeerah Suhaimi
author_facet	Suhaimi, Nur Ajeerah
author_sort	Suhaimi, Nur Ajeerah
title	Anti-infertility assessments of Ficus deltoidea var. kunstleri ethanolic leaves extract in letrozole-induced polycystic ovarian syndrome rats / Nur Ajeerah Suhaimi
title_short	Anti-infertility assessments of Ficus deltoidea var. kunstleri ethanolic leaves extract in letrozole-induced polycystic ovarian syndrome rats / Nur Ajeerah Suhaimi
title_full	Anti-infertility assessments of Ficus deltoidea var. kunstleri ethanolic leaves extract in letrozole-induced polycystic ovarian syndrome rats / Nur Ajeerah Suhaimi
title_fullStr	Anti-infertility assessments of Ficus deltoidea var. kunstleri ethanolic leaves extract in letrozole-induced polycystic ovarian syndrome rats / Nur Ajeerah Suhaimi
title_full_unstemmed	Anti-infertility assessments of Ficus deltoidea var. kunstleri ethanolic leaves extract in letrozole-induced polycystic ovarian syndrome rats / Nur Ajeerah Suhaimi
title_sort	anti-infertility assessments of ficus deltoidea var. kunstleri ethanolic leaves extract in letrozole-induced polycystic ovarian syndrome rats / nur ajeerah suhaimi
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Applied Sciences
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/38025/1/38025.pdf
_version_	1783734450529501184

Anti-infertility assessments of Ficus deltoidea var. kunstleri ethanolic leaves extract in letrozole-induced polycystic ovarian syndrome rats / Nur Ajeerah Suhaimi

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