The impact of pharmacist counselling on patient medication adherence and helicobacter pylori eradication rate in Jordanian outpatients / Aiman Ahmad Saleem Shoiab
Background: Patient's adherence to Helicobacter pylori (H. pylori) regimen has a critical effect on its outcome. There is a great interest to assess the impact of pharmacist counselling, treatment characteristics, patient's knowledge, patient's sociodemographic and medical history on...
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| Format: | Thesis |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ir.uitm.edu.my/id/eprint/39323/1/39323.pdf |
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| Summary: | Background: Patient's adherence to Helicobacter pylori (H. pylori) regimen has a critical effect on its outcome. There is a great interest to assess the impact of pharmacist counselling, treatment characteristics, patient's knowledge, patient's sociodemographic and medical history on medication adherence and H. pylori eradication rate. Objectives: This study assessed the impact of pharmacist counselling, patient's knowledge, socio-demographic and medical history on medication adherence and H. pylori eradication rate. Methods: This is a prospective, randomized, controlled study, conducted on Jordanian H. pylori infected outpatients. A total of 200 patients have volunteered and met the inclusion criteria that were randomly assigned for intervention and control groups. To avoid the contamination between these patients, the study population WAS separated by a reasonable geographical distance and there was no relationship between them. Each group consisted of 100 patients, the intervention group was subjected to pharmacist counselling, then followed-up for 14 days, while the control group went through normal hospital procedure. Medication adherence in both groups was assessed by the Morisky Medication Adherence Scale-8 (MMAS-8) and pill count method. Data were collected from patients in both groups through questionnaires, medical records and laboratory test results. Four weeks following the completed eradication regimen, both groups were subjected to stool antigen test and dyspeptic symptoms assessment to confirm H. pylori eradication. Data were analyzed by the statistical package for social sciences (SPSS v20). Results and Discussion: 51.5% of patients were male, where their mean age was 44.9 ± 14.9 years. There were significant differences in medication adherence by pill count (27.0%, 45.5%), by MMAS-8 scale (28.5%, 46.0%), and a significant difference in eradication rate (27.5%, 43.5%) after applying pharmacist counselling. However, pharmacist counselling was not a significant predictor of medication adherence and H. pylori eradication rate. There was no association between the patient's sociodemographic and medical history with medication adherence. The relationships between the regimen complexity and side effect with medication adherence and H. pylori eradication rate were significant. Furthermore, regimen complexity was a significant predictor of medication adherence with P < 0.05, while regimen side effect was not a predictor of medication adherence and both were not predictors of H. pylori eradication rate. There was a significant difference in a sufficient patient's knowledge after receiving pharmacist counselling with 25.5% and 50.5%. Furthermore, the relationships between a patient's knowledge with medication adherence (measured by pill count and MMAS-8 scale) and the eradication rate were significant. The patient's knowledge was a good predictor of medication adherence and H. pylori eradication rate. The association of medication adherence with H. pylori eradication rate was a significant predictor of eradication with P < 0.05. Successful H. pylori eradication significantly improved dyspeptic symptoms. Conclusion: This study reflects the importance role of pharmacist counselling, patient's knowledge and patient's medication adherence in successful eradication rate, whereas patients who received pharmacist counselling exhibited a sufficient knowledge and a perfect rate of medication adherence and in turn lead to successful H. pylori eradication. |
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