Sustaining drug release of chitosan spheroids produced by an extrusion-spheronization technique / Lidawati Zakaria

The sustained-release chitosan-alginate spheroids have lately been designed by means of melt pelletization technique. The melt pelletization operates via heating and melting a binder to agglomerate chitosan and alginate into spheroids. Different from melt pelletization, the extrusion-spheronization...

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Main Author:	Zakaria, Lidawati
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Drugs and their actions Chemical engineering
Online Access:	https://ir.uitm.edu.my/id/eprint/39442/1/39442.pdf
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id	my-uitm-ir.39442
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spelling	my-uitm-ir.394422024-08-02T03:23:05Z Sustaining drug release of chitosan spheroids produced by an extrusion-spheronization technique / Lidawati Zakaria 2017 Zakaria, Lidawati Drugs and their actions Chemical engineering The sustained-release chitosan-alginate spheroids have lately been designed by means of melt pelletization technique. The melt pelletization operates via heating and melting a binder to agglomerate chitosan and alginate into spheroids. Different from melt pelletization, the extrusion-spheronization processes are operated at room temperature and are envisaged to bring about a lower level of material degradation. The study examined the formulation and drug release aspects of chitosan spheroids as a function of crosslinking and coacervation reactions between chitosan, tripolyphosphate and alginate. It identifies useful polymer reaction mode and evaluates its applicability in sustained-release chitosan spheroid formulation. Microwave was employed as drying tool to solidify the formed crosslinkages at a rapid rate prior to their dissociation. Seven types of spheroids were prepared using the extrusion-spheronization technique. Sodium tripolyphosphate was used as a crosslinker and chlorphenamine maleate as a model drug. Chitosan spheroids demonstrated a fast drug dissolution profile with more than 60 % drug released within 2 h of dissolution. Crosslinking of chitosan in matrix by tripolyphosphate ions was accompanied by channeling effect in matrix thus promoting fast drug release. Spheroids produced using deionized water as granulating liquid had better drug release retardation property than those produced using solutions of acetic acid and citric acid. Use of organic acid did not promote drug release retardation through enhancing chitosan-tripolyphosphate crosslinkage in acid milieu. The treatment of tripolyphosphate crosslinked-chitosan spheroids by microwave only reduced the extent of drug release by a small extent. The tripolyphosphate-crosslinked chitosan spheroids exhibited a higher extent of drug release than the untreated spheroids following matrix acidification and microwave drying of spheroids as a result of pore formation. The chitosan spheroids were characterized by fast drug release when both sodium tripolyphosphate and sodium alginate were embedded in the same matrix. Formulation of chitosan with alginate per se decreased the disintegration capacity of chitosan spheroids thereby lowering their drug release at the initial phase of dissolution. Different from alginate spheroids which underwent matrix erosion to a large extent, the availability of chitosan and alginate in the same matrix retained the microstructure of spheroids. Both chitosan and alginate were coacervated into patches of membrane covering the surfaces and inner core of spheroids during the process of dissolution. 2017 Thesis https://ir.uitm.edu.my/id/eprint/39442/ https://ir.uitm.edu.my/id/eprint/39442/1/39442.pdf text en public masters Universiti Teknologi MARA (UiTM) Faculty of Pharmacy Wong, Tin Wui
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Wong, Tin Wui
topic	Drugs and their actions Chemical engineering
spellingShingle	Drugs and their actions Chemical engineering Zakaria, Lidawati Sustaining drug release of chitosan spheroids produced by an extrusion-spheronization technique / Lidawati Zakaria
description	The sustained-release chitosan-alginate spheroids have lately been designed by means of melt pelletization technique. The melt pelletization operates via heating and melting a binder to agglomerate chitosan and alginate into spheroids. Different from melt pelletization, the extrusion-spheronization processes are operated at room temperature and are envisaged to bring about a lower level of material degradation. The study examined the formulation and drug release aspects of chitosan spheroids as a function of crosslinking and coacervation reactions between chitosan, tripolyphosphate and alginate. It identifies useful polymer reaction mode and evaluates its applicability in sustained-release chitosan spheroid formulation. Microwave was employed as drying tool to solidify the formed crosslinkages at a rapid rate prior to their dissociation. Seven types of spheroids were prepared using the extrusion-spheronization technique. Sodium tripolyphosphate was used as a crosslinker and chlorphenamine maleate as a model drug. Chitosan spheroids demonstrated a fast drug dissolution profile with more than 60 % drug released within 2 h of dissolution. Crosslinking of chitosan in matrix by tripolyphosphate ions was accompanied by channeling effect in matrix thus promoting fast drug release. Spheroids produced using deionized water as granulating liquid had better drug release retardation property than those produced using solutions of acetic acid and citric acid. Use of organic acid did not promote drug release retardation through enhancing chitosan-tripolyphosphate crosslinkage in acid milieu. The treatment of tripolyphosphate crosslinked-chitosan spheroids by microwave only reduced the extent of drug release by a small extent. The tripolyphosphate-crosslinked chitosan spheroids exhibited a higher extent of drug release than the untreated spheroids following matrix acidification and microwave drying of spheroids as a result of pore formation. The chitosan spheroids were characterized by fast drug release when both sodium tripolyphosphate and sodium alginate were embedded in the same matrix. Formulation of chitosan with alginate per se decreased the disintegration capacity of chitosan spheroids thereby lowering their drug release at the initial phase of dissolution. Different from alginate spheroids which underwent matrix erosion to a large extent, the availability of chitosan and alginate in the same matrix retained the microstructure of spheroids. Both chitosan and alginate were coacervated into patches of membrane covering the surfaces and inner core of spheroids during the process of dissolution.
format	Thesis
qualification_level	Master's degree
author	Zakaria, Lidawati
author_facet	Zakaria, Lidawati
author_sort	Zakaria, Lidawati
title	Sustaining drug release of chitosan spheroids produced by an extrusion-spheronization technique / Lidawati Zakaria
title_short	Sustaining drug release of chitosan spheroids produced by an extrusion-spheronization technique / Lidawati Zakaria
title_full	Sustaining drug release of chitosan spheroids produced by an extrusion-spheronization technique / Lidawati Zakaria
title_fullStr	Sustaining drug release of chitosan spheroids produced by an extrusion-spheronization technique / Lidawati Zakaria
title_full_unstemmed	Sustaining drug release of chitosan spheroids produced by an extrusion-spheronization technique / Lidawati Zakaria
title_sort	sustaining drug release of chitosan spheroids produced by an extrusion-spheronization technique / lidawati zakaria
granting_institution	Universiti Teknologi MARA (UiTM)
granting_department	Faculty of Pharmacy
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/39442/1/39442.pdf
_version_	1811768626491949056

Sustaining drug release of chitosan spheroids produced by an extrusion-spheronization technique / Lidawati Zakaria

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