Investigation of solution thermodynamics and solute characterization of citric acid polymorphs / Farah Eliza Mohamed Rasidi
Crystallization is an important industrial process used in a multitude of different industries including pharmaceutical-, chemical production-, and food industry. In pharmaceutical industry, new polymorphs and transition of polymorphs may appear spontaneously from less stable to more stable. The sce...
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2012
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my-uitm-ir.396032023-01-12T07:29:48Z Investigation of solution thermodynamics and solute characterization of citric acid polymorphs / Farah Eliza Mohamed Rasidi 2012 Mohamed Rasidi, Farah Eliza Mechanics of engineering. Applied mechanics Dynamic loading conditions. Structural dynamics. Vibrations Crystallization is an important industrial process used in a multitude of different industries including pharmaceutical-, chemical production-, and food industry. In pharmaceutical industry, new polymorphs and transition of polymorphs may appear spontaneously from less stable to more stable. The scenario occurs due to the manufacturing process (addition of solvent), changes in the equipment used to dry the final drug substance, and conditions of materials to be stored. The objective of crystallization is to produce high quality crystals with desirable macro- and microscopic properties, shape and desired polymorph and enabling them to be utilized in end user specific applications. The scope of the studies consists of two sections which covers the determination of activity coefficients and behaviour and structure of citric acid. Analytical gravimetric solubility studies of anhydrous and monohydrate citric acid in conjunction with Van’t Hoff plots have elucidated specific polymorphic thermodynamic properties; enthalpy, entropy and activity coefficients. The solubility characteristics exhibited infer that the polymorphs undergo transition at TEMPERATURE and are enantiotropically related. Polymorph screening and molecular modeling studies indicate that the addition of impurities lo a pure solvent solute system can initiate polymorphic transition. Specifically; the presence of polar molecules appears to initiate transition from the anhydrous to the monohydrate polymorph of citric acid. 2012 Thesis https://ir.uitm.edu.my/id/eprint/39603/ https://ir.uitm.edu.my/id/eprint/39603/1/39603.pdf text en public masters Universiti Teknologi MARA Faculty of Chemical Engineering |
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Universiti Teknologi MARA |
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UiTM Institutional Repository |
| language |
English |
| topic |
Mechanics of engineering Applied mechanics Mechanics of engineering Applied mechanics |
| spellingShingle |
Mechanics of engineering Applied mechanics Mechanics of engineering Applied mechanics Mohamed Rasidi, Farah Eliza Investigation of solution thermodynamics and solute characterization of citric acid polymorphs / Farah Eliza Mohamed Rasidi |
| description |
Crystallization is an important industrial process used in a multitude of different industries including pharmaceutical-, chemical production-, and food industry. In pharmaceutical industry, new polymorphs and transition of polymorphs may appear spontaneously from less stable to more stable. The scenario occurs due to the manufacturing process (addition of solvent), changes in the equipment used to dry the final drug substance, and conditions of materials to be stored. The objective of crystallization is to produce high quality crystals with desirable macro- and microscopic properties, shape and desired polymorph and enabling them to be utilized in end user specific applications. The scope of the studies consists of two sections which covers the determination of activity coefficients and behaviour and structure of citric acid. Analytical gravimetric solubility studies of anhydrous and monohydrate citric acid in conjunction with Van’t Hoff plots have elucidated specific polymorphic thermodynamic properties; enthalpy, entropy and activity coefficients. The solubility characteristics exhibited infer that the polymorphs undergo transition at TEMPERATURE and are enantiotropically related. Polymorph screening and molecular modeling studies indicate that the addition of impurities lo a pure solvent solute system can initiate polymorphic transition. Specifically; the presence of polar molecules appears to initiate transition from the anhydrous to the monohydrate polymorph of citric acid. |
| format |
Thesis |
| qualification_level |
Master's degree |
| author |
Mohamed Rasidi, Farah Eliza |
| author_facet |
Mohamed Rasidi, Farah Eliza |
| author_sort |
Mohamed Rasidi, Farah Eliza |
| title |
Investigation of solution thermodynamics and solute characterization of citric acid polymorphs / Farah Eliza Mohamed Rasidi |
| title_short |
Investigation of solution thermodynamics and solute characterization of citric acid polymorphs / Farah Eliza Mohamed Rasidi |
| title_full |
Investigation of solution thermodynamics and solute characterization of citric acid polymorphs / Farah Eliza Mohamed Rasidi |
| title_fullStr |
Investigation of solution thermodynamics and solute characterization of citric acid polymorphs / Farah Eliza Mohamed Rasidi |
| title_full_unstemmed |
Investigation of solution thermodynamics and solute characterization of citric acid polymorphs / Farah Eliza Mohamed Rasidi |
| title_sort |
investigation of solution thermodynamics and solute characterization of citric acid polymorphs / farah eliza mohamed rasidi |
| granting_institution |
Universiti Teknologi MARA |
| granting_department |
Faculty of Chemical Engineering |
| publishDate |
2012 |
| url |
https://ir.uitm.edu.my/id/eprint/39603/1/39603.pdf |
| _version_ |
1783734521505513472 |