Superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / Sharipah Razali

Solid dispersion utilizing superdisintegrants and effervescent agents was met with slow matrix disaggregation during dissolution and effervescence loss during storage, thereby delaying drug dissolution. This study employed electrolyte as alternative dispersant of fast-release matrix prepared using s...

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Main Author:	Razali, Sharipah
Format:	Thesis
Language:	English
Published:	2012
Subjects:	Materia medica
Online Access:	https://ir.uitm.edu.my/id/eprint/39614/1/39614.pdf
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id	my-uitm-ir.39614
record_format	uketd_dc
spelling	my-uitm-ir.396142020-12-24T03:57:49Z Superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / Sharipah Razali 2012-10 Razali, Sharipah Materia medica Solid dispersion utilizing superdisintegrants and effervescent agents was met with slow matrix disaggregation during dissolution and effervescence loss during storage, thereby delaying drug dissolution. This study employed electrolyte as alternative dispersant of fast-release matrix prepared using solvent-free melt pelletization technique which prevented instantaneous reaction between electrolyte and solvent during agglomeration and allowed such reaction to occur only in dissolution phase. The melt pellets were prepared using lactose and polyethylene glycol (PEG) 3000 as hydrophilic carriers, calcium acetate and calcium carbonate as electrolytes, tolbutamide as poorly water-soluble drug in free form and embedded in PEG 3000. These pellets were subjected to drug dissolution and physicochemical tests at molecular scale. The dissolution of tolbutamide in simulated gastric milieu increased following its formulation into pellets due to enhanced drug segregation and amorphization. A further increase in drug dissolution was attainable through pellet formulation with water-soluble calcium acetate instead of effervescent acid-soluble carbonate salt. Calcium acetate dissolved rapidly in aqueous medium to initiate turbulence in core matrix and fast pellet break-up through erosion and disintegration. Small dispersible particles with elevated dissolution surface area were formed and had pellet fast-release characteristics unaffected by prolonged matrix storage for 17 months at 25 °C and 50% relative humidity. 2012-10 Thesis https://ir.uitm.edu.my/id/eprint/39614/ https://ir.uitm.edu.my/id/eprint/39614/1/39614.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy Wong, Tin Wui (Assoc. Prof. Dr. )
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Wong, Tin Wui (Assoc. Prof. Dr. )
topic	Materia medica
spellingShingle	Materia medica Razali, Sharipah Superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / Sharipah Razali
description	Solid dispersion utilizing superdisintegrants and effervescent agents was met with slow matrix disaggregation during dissolution and effervescence loss during storage, thereby delaying drug dissolution. This study employed electrolyte as alternative dispersant of fast-release matrix prepared using solvent-free melt pelletization technique which prevented instantaneous reaction between electrolyte and solvent during agglomeration and allowed such reaction to occur only in dissolution phase. The melt pellets were prepared using lactose and polyethylene glycol (PEG) 3000 as hydrophilic carriers, calcium acetate and calcium carbonate as electrolytes, tolbutamide as poorly water-soluble drug in free form and embedded in PEG 3000. These pellets were subjected to drug dissolution and physicochemical tests at molecular scale. The dissolution of tolbutamide in simulated gastric milieu increased following its formulation into pellets due to enhanced drug segregation and amorphization. A further increase in drug dissolution was attainable through pellet formulation with water-soluble calcium acetate instead of effervescent acid-soluble carbonate salt. Calcium acetate dissolved rapidly in aqueous medium to initiate turbulence in core matrix and fast pellet break-up through erosion and disintegration. Small dispersible particles with elevated dissolution surface area were formed and had pellet fast-release characteristics unaffected by prolonged matrix storage for 17 months at 25 °C and 50% relative humidity.
format	Thesis
qualification_level	Master's degree
author	Razali, Sharipah
author_facet	Razali, Sharipah
author_sort	Razali, Sharipah
title	Superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / Sharipah Razali
title_short	Superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / Sharipah Razali
title_full	Superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / Sharipah Razali
title_fullStr	Superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / Sharipah Razali
title_full_unstemmed	Superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / Sharipah Razali
title_sort	superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / sharipah razali
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2012
url	https://ir.uitm.edu.my/id/eprint/39614/1/39614.pdf
_version_	1783734522296139776

Superdisintegrant- and effervescent agent-less dispersible fast-release tolbutamide matrix prepared by melt pelletization technique / Sharipah Razali

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