Plasticity of hot air-dried mannuronate-and guluronate-rich alginate films for application in transdermal drug delivery system / Noor Shimariza Ashikin Wan Hussin

The plasticity of hot air-dried guluronate-rich (MG) and mannuronate-rich (MC) alginate films prepared from 2 and 4% (w/w) alginate solutions, which contained the same amount of polymer, through hot-air drying at 40 to 80°C were investigated. These films were subjected to thermomechanical, different...

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Main Author:	Wan Hussin, Noor Shimariza Ashikin
Format:	Thesis
Language:	English
Published:	2011
Subjects:	RM Therapeutics Pharmacology Administration
Online Access:	https://ir.uitm.edu.my/id/eprint/39760/1/39760.pdf
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spelling	my-uitm-ir.397602021-08-30T04:55:17Z Plasticity of hot air-dried mannuronate-and guluronate-rich alginate films for application in transdermal drug delivery system / Noor Shimariza Ashikin Wan Hussin 2011-02 Wan Hussin, Noor Shimariza Ashikin RM Therapeutics. Pharmacology Administration The plasticity of hot air-dried guluronate-rich (MG) and mannuronate-rich (MC) alginate films prepared from 2 and 4% (w/w) alginate solutions, which contained the same amount of polymer, through hot-air drying at 40 to 80°C were investigated. These films were subjected to thermomechanical, differential scanning calorimetry, Fourier-transform infra-red, x-ray diffractometry, dimension, morphology, moisture content, viscosity and polymer molecular weight analysis. The water weight loss profile of alginate solution undergoing drying was recorded with time. The polymer weight of all solid films was kept constant. Film plasticity increased when dilute alginate solution and MC were employed in film preparation. This was due to decrease in polymer-polymer interaction at high strength domains of matrix involving C-H, O-H, C-0 and/or C=0 moiety of alginate, attributing to plasticization effect of water and ease of molecular rearrangement of alginate. The plasticity of film decreased with an increase in drying temperature from 40 to 60°C following heat-induced polymer-polymer interaction. A further increase in drying temperature to 80°C nonetheless greatly promoted film plasticity through air bubble formation and reduced alginate molecular weight in film. Drying of dilute alginate solution or at low drying temperature was accompanied by both constant rate and falling rate periods. The falling rate period dominated in drying of alginate solution of high polymer concentration and at high drying temperatures with internal diffusion being the governing transport phenomenon for water. Drying process of 4% (w/w) alginate solution at 60 and 80°C was relatively simple as there was only a single drying stage. Nonetheless, it could give rise to different product plasticity's in spite of being convenience with respect to process control. 2011-02 Thesis https://ir.uitm.edu.my/id/eprint/39760/ https://ir.uitm.edu.my/id/eprint/39760/1/39760.pdf text en public masters Universiti Teknologi MARA Faculty of Pharmacy Wong, Tin Wu (Assoc. Prof. Dr. )
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Wong, Tin Wu (Assoc. Prof. Dr. )
topic	RM Therapeutics Pharmacology Administration
spellingShingle	RM Therapeutics Pharmacology Administration Wan Hussin, Noor Shimariza Ashikin Plasticity of hot air-dried mannuronate-and guluronate-rich alginate films for application in transdermal drug delivery system / Noor Shimariza Ashikin Wan Hussin
description	The plasticity of hot air-dried guluronate-rich (MG) and mannuronate-rich (MC) alginate films prepared from 2 and 4% (w/w) alginate solutions, which contained the same amount of polymer, through hot-air drying at 40 to 80°C were investigated. These films were subjected to thermomechanical, differential scanning calorimetry, Fourier-transform infra-red, x-ray diffractometry, dimension, morphology, moisture content, viscosity and polymer molecular weight analysis. The water weight loss profile of alginate solution undergoing drying was recorded with time. The polymer weight of all solid films was kept constant. Film plasticity increased when dilute alginate solution and MC were employed in film preparation. This was due to decrease in polymer-polymer interaction at high strength domains of matrix involving C-H, O-H, C-0 and/or C=0 moiety of alginate, attributing to plasticization effect of water and ease of molecular rearrangement of alginate. The plasticity of film decreased with an increase in drying temperature from 40 to 60°C following heat-induced polymer-polymer interaction. A further increase in drying temperature to 80°C nonetheless greatly promoted film plasticity through air bubble formation and reduced alginate molecular weight in film. Drying of dilute alginate solution or at low drying temperature was accompanied by both constant rate and falling rate periods. The falling rate period dominated in drying of alginate solution of high polymer concentration and at high drying temperatures with internal diffusion being the governing transport phenomenon for water. Drying process of 4% (w/w) alginate solution at 60 and 80°C was relatively simple as there was only a single drying stage. Nonetheless, it could give rise to different product plasticity's in spite of being convenience with respect to process control.
format	Thesis
qualification_level	Master's degree
author	Wan Hussin, Noor Shimariza Ashikin
author_facet	Wan Hussin, Noor Shimariza Ashikin
author_sort	Wan Hussin, Noor Shimariza Ashikin
title	Plasticity of hot air-dried mannuronate-and guluronate-rich alginate films for application in transdermal drug delivery system / Noor Shimariza Ashikin Wan Hussin
title_short	Plasticity of hot air-dried mannuronate-and guluronate-rich alginate films for application in transdermal drug delivery system / Noor Shimariza Ashikin Wan Hussin
title_full	Plasticity of hot air-dried mannuronate-and guluronate-rich alginate films for application in transdermal drug delivery system / Noor Shimariza Ashikin Wan Hussin
title_fullStr	Plasticity of hot air-dried mannuronate-and guluronate-rich alginate films for application in transdermal drug delivery system / Noor Shimariza Ashikin Wan Hussin
title_full_unstemmed	Plasticity of hot air-dried mannuronate-and guluronate-rich alginate films for application in transdermal drug delivery system / Noor Shimariza Ashikin Wan Hussin
title_sort	plasticity of hot air-dried mannuronate-and guluronate-rich alginate films for application in transdermal drug delivery system / noor shimariza ashikin wan hussin
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Pharmacy
publishDate	2011
url	https://ir.uitm.edu.my/id/eprint/39760/1/39760.pdf
_version_	1783734535242907648

Plasticity of hot air-dried mannuronate-and guluronate-rich alginate films for application in transdermal drug delivery system / Noor Shimariza Ashikin Wan Hussin

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