Detection of Staphylococcus epidermidis either a pathogen or a commensal / Masitah Ismail

Staphylococcus epidermidis is one of the common contaminants isolated in clinical samples. This microorganism has been long treated as non-pathogenic bacteria because there are no sufficient evidence and studies conducted to determine the clinical importance of Staphylococcus epidermidis. A prospect...

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Main Author:	Ismail, Masitah
Format:	Thesis
Language:	English
Published:	2007
Subjects:	QR Microbiology Microbial ecology
Online Access:	https://ir.uitm.edu.my/id/eprint/47498/1/47498.pdf
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spelling	my-uitm-ir.474982021-11-09T02:43:43Z Detection of Staphylococcus epidermidis either a pathogen or a commensal / Masitah Ismail 2007 Ismail, Masitah QR Microbiology Microbial ecology Staphylococcus epidermidis is one of the common contaminants isolated in clinical samples. This microorganism has been long treated as non-pathogenic bacteria because there are no sufficient evidence and studies conducted to determine the clinical importance of Staphylococcus epidermidis. A prospective study was conducted to determine the clinical importance of Staphylococcus epidermidis and further test to confirm its pathogencity features and susceptibility pattern. This study consists of 20 subjects with suspected upper respiratory tract infections such as cough and sore throat. Since there were no medical cares or drugs administration, it reflexes its non-severity. Although, it may persist as a pathogen with comparatively low virulence factors, extended duration may lead to severe diseases, which in turn encourage the initiation of secondary bacterial infections. Ten isolates of Staphylococcus epidermidis were obtained from the 20 subjects and the isolates were subjected to biochemical tests for isolation and characterization. In order to meet National Committee for Clinical Laboratory, Kirby Bauer's disc diffusion was adopted to study the susceptibility patterns of Staphylococcus epidermidis. The study revealed that that 90% Staphylococcus epidermidis isolates were sensitive to Ciprofloxacin (5mcg) and Ampicilin/Sulbactam (20mcg) but 70% of the confirmed isolates were resistant to Penicillin G and Vancomycin, 60% of confirmed isolates were resistant to Ampicilin and 50% of the Staphylococcus epidermidis isolates were resistant to oxacillin respectively. This suggests that, Ciprofloxacin and Ampicillin/ Sulbactam (SAM) could be used in the treatment of multiresistant Staphylococcus epidermidis infections. The findings of this project not only indicate that regular observation of the drug is necessary, the drug's policy also need to be strictly followed by clinician to avoid emergence of resistant Staphylococcus epidermidis. Ideally, the prevention of Staphylococcus epidermidis infections based on better understanding of epidemiology, hospital reservoirs, mechanism of transmission and host defense against these organisms. 2007 Thesis https://ir.uitm.edu.my/id/eprint/47498/ https://ir.uitm.edu.my/id/eprint/47498/1/47498.pdf text en public degree Universiti Teknologi MARA Faculty of Health Science Rambley, Azlin Sham
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Rambley, Azlin Sham
topic	QR Microbiology Microbial ecology
spellingShingle	QR Microbiology Microbial ecology Ismail, Masitah Detection of Staphylococcus epidermidis either a pathogen or a commensal / Masitah Ismail
description	Staphylococcus epidermidis is one of the common contaminants isolated in clinical samples. This microorganism has been long treated as non-pathogenic bacteria because there are no sufficient evidence and studies conducted to determine the clinical importance of Staphylococcus epidermidis. A prospective study was conducted to determine the clinical importance of Staphylococcus epidermidis and further test to confirm its pathogencity features and susceptibility pattern. This study consists of 20 subjects with suspected upper respiratory tract infections such as cough and sore throat. Since there were no medical cares or drugs administration, it reflexes its non-severity. Although, it may persist as a pathogen with comparatively low virulence factors, extended duration may lead to severe diseases, which in turn encourage the initiation of secondary bacterial infections. Ten isolates of Staphylococcus epidermidis were obtained from the 20 subjects and the isolates were subjected to biochemical tests for isolation and characterization. In order to meet National Committee for Clinical Laboratory, Kirby Bauer's disc diffusion was adopted to study the susceptibility patterns of Staphylococcus epidermidis. The study revealed that that 90% Staphylococcus epidermidis isolates were sensitive to Ciprofloxacin (5mcg) and Ampicilin/Sulbactam (20mcg) but 70% of the confirmed isolates were resistant to Penicillin G and Vancomycin, 60% of confirmed isolates were resistant to Ampicilin and 50% of the Staphylococcus epidermidis isolates were resistant to oxacillin respectively. This suggests that, Ciprofloxacin and Ampicillin/ Sulbactam (SAM) could be used in the treatment of multiresistant Staphylococcus epidermidis infections. The findings of this project not only indicate that regular observation of the drug is necessary, the drug's policy also need to be strictly followed by clinician to avoid emergence of resistant Staphylococcus epidermidis. Ideally, the prevention of Staphylococcus epidermidis infections based on better understanding of epidemiology, hospital reservoirs, mechanism of transmission and host defense against these organisms.
format	Thesis
qualification_level	Bachelor degree
author	Ismail, Masitah
author_facet	Ismail, Masitah
author_sort	Ismail, Masitah
title	Detection of Staphylococcus epidermidis either a pathogen or a commensal / Masitah Ismail
title_short	Detection of Staphylococcus epidermidis either a pathogen or a commensal / Masitah Ismail
title_full	Detection of Staphylococcus epidermidis either a pathogen or a commensal / Masitah Ismail
title_fullStr	Detection of Staphylococcus epidermidis either a pathogen or a commensal / Masitah Ismail
title_full_unstemmed	Detection of Staphylococcus epidermidis either a pathogen or a commensal / Masitah Ismail
title_sort	detection of staphylococcus epidermidis either a pathogen or a commensal / masitah ismail
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Health Science
publishDate	2007
url	https://ir.uitm.edu.my/id/eprint/47498/1/47498.pdf
_version_	1783734781061627904

Detection of Staphylococcus epidermidis either a pathogen or a commensal / Masitah Ismail

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