Antimicrobial activity of acetone extract of senna alata leaf against skin pathogen / Nor Shela Kamarudin

Senna alata also known as ―Pokok gelenggang‖ is one of the plants that are used as a traditional medicine for long time ago. The Senna alata is able to treat diarrhea, dysentery and other gasterointestinal problem. Moreover, it is also reported to have antifungal activity. The present study was init...

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Main Author:	Kamarudin, Nor Shela
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Organic chemistry Antibacterial agents Acetone
Online Access:	https://ir.uitm.edu.my/id/eprint/50196/1/50196.pdf
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id	my-uitm-ir.50196
record_format	uketd_dc
spelling	my-uitm-ir.501962021-09-08T08:37:14Z Antimicrobial activity of acetone extract of senna alata leaf against skin pathogen / Nor Shela Kamarudin 2017 Kamarudin, Nor Shela Organic chemistry Antibacterial agents Flowers and flower culture. Ornamental plants Acetone Senna alata also known as ―Pokok gelenggang‖ is one of the plants that are used as a traditional medicine for long time ago. The Senna alata is able to treat diarrhea, dysentery and other gasterointestinal problem. Moreover, it is also reported to have antifungal activity. The present study was initiated to explore the antimicrobial activity of acetone extract of Senna alata leaf against skin pathogen. Thus, the extract of Senna alata leaf was prepared using acetone as an extraction solvent. Acetone extractions were done using maceration technique. In order to determine the antimicrobial activity of Senna alata against skin pathogen which is S. aureus, S. epidermidis, P. aeruginosa and P. mirabilis, Antimicrobial Susceptibility Testing (AST) by disc diffusion method and Minimal Inhibitory Concentration (MIC) by using microdilution broth assays were performed. Significant results of Senna alata leaf extract effect are shown in S. aureus, S. epidermidis and P.mirabilis. The result for AST showed largest inhibition zone against Staphylococcus epidermidis (13.67mm±1.52). It was followed by Staphylococcus aureus (11.33mm±1.15) and Proteus mirabilis (9.0mm±1.0). While, for Pseudomonas aeruginosa showed no inhibition zone at all. The MIC showed that S. epidermidis had the lowest MIC value (31.25mg/ml). S. aureus had 62.5 mg/ml meanwhile P. mirabilis had 250 mg/ml of MIC value. As a conclusion, acetone extract of Senna alata leaf had antimicrobial activity against skin pathogen and had a potential to use as natural product in antimicrobial agents. 2017 Thesis https://ir.uitm.edu.my/id/eprint/50196/ https://ir.uitm.edu.my/id/eprint/50196/1/50196.pdf text en public degree Universiti Teknologi Mara (Kampus Puncak Alam) Faculty of Health Sciences Wan Mohamad, Wan Kamil
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Wan Mohamad, Wan Kamil
topic	Organic chemistry Antibacterial agents Organic chemistry Acetone
spellingShingle	Organic chemistry Antibacterial agents Organic chemistry Acetone Kamarudin, Nor Shela Antimicrobial activity of acetone extract of senna alata leaf against skin pathogen / Nor Shela Kamarudin
description	Senna alata also known as ―Pokok gelenggang‖ is one of the plants that are used as a traditional medicine for long time ago. The Senna alata is able to treat diarrhea, dysentery and other gasterointestinal problem. Moreover, it is also reported to have antifungal activity. The present study was initiated to explore the antimicrobial activity of acetone extract of Senna alata leaf against skin pathogen. Thus, the extract of Senna alata leaf was prepared using acetone as an extraction solvent. Acetone extractions were done using maceration technique. In order to determine the antimicrobial activity of Senna alata against skin pathogen which is S. aureus, S. epidermidis, P. aeruginosa and P. mirabilis, Antimicrobial Susceptibility Testing (AST) by disc diffusion method and Minimal Inhibitory Concentration (MIC) by using microdilution broth assays were performed. Significant results of Senna alata leaf extract effect are shown in S. aureus, S. epidermidis and P.mirabilis. The result for AST showed largest inhibition zone against Staphylococcus epidermidis (13.67mm±1.52). It was followed by Staphylococcus aureus (11.33mm±1.15) and Proteus mirabilis (9.0mm±1.0). While, for Pseudomonas aeruginosa showed no inhibition zone at all. The MIC showed that S. epidermidis had the lowest MIC value (31.25mg/ml). S. aureus had 62.5 mg/ml meanwhile P. mirabilis had 250 mg/ml of MIC value. As a conclusion, acetone extract of Senna alata leaf had antimicrobial activity against skin pathogen and had a potential to use as natural product in antimicrobial agents.
format	Thesis
qualification_level	Bachelor degree
author	Kamarudin, Nor Shela
author_facet	Kamarudin, Nor Shela
author_sort	Kamarudin, Nor Shela
title	Antimicrobial activity of acetone extract of senna alata leaf against skin pathogen / Nor Shela Kamarudin
title_short	Antimicrobial activity of acetone extract of senna alata leaf against skin pathogen / Nor Shela Kamarudin
title_full	Antimicrobial activity of acetone extract of senna alata leaf against skin pathogen / Nor Shela Kamarudin
title_fullStr	Antimicrobial activity of acetone extract of senna alata leaf against skin pathogen / Nor Shela Kamarudin
title_full_unstemmed	Antimicrobial activity of acetone extract of senna alata leaf against skin pathogen / Nor Shela Kamarudin
title_sort	antimicrobial activity of acetone extract of senna alata leaf against skin pathogen / nor shela kamarudin
granting_institution	Universiti Teknologi Mara (Kampus Puncak Alam)
granting_department	Faculty of Health Sciences
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/50196/1/50196.pdf
_version_	1783734824317485056

Antimicrobial activity of acetone extract of senna alata leaf against skin pathogen / Nor Shela Kamarudin

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