In vitro haemostatic activity of rhodomyrtus tomentosa methanol stem extract / Rabiul Hamizah Mohamad Norzaini

Anticoagulants from natural origins can be a good source to treat haemostatic disorders. One of them is, a rose myrtle (Rhodomyrtus tomentosa (Aiton) Hassk.), locally known as ‘kemunting’. This study aimed to determine the haemostatic activity of Rhodomyrtus tomentosa methanol stem extract concentra...

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Main Author:	Mohamad Norzaini, Rabiul Hamizah
Format:	Thesis
Language:	English
Published:	2017
Subjects:	Botanical chemistry Phytochemicals Drugs and their actions
Online Access:	https://ir.uitm.edu.my/id/eprint/50365/1/50365.pdf
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id	my-uitm-ir.50365
record_format	uketd_dc
spelling	my-uitm-ir.503652021-09-13T03:09:24Z In vitro haemostatic activity of rhodomyrtus tomentosa methanol stem extract / Rabiul Hamizah Mohamad Norzaini 2017 Mohamad Norzaini, Rabiul Hamizah Botanical chemistry. Phytochemicals Drugs and their actions Flowers and flower culture. Ornamental plants Anticoagulants from natural origins can be a good source to treat haemostatic disorders. One of them is, a rose myrtle (Rhodomyrtus tomentosa (Aiton) Hassk.), locally known as ‘kemunting’. This study aimed to determine the haemostatic activity of Rhodomyrtus tomentosa methanol stem extract concentration ranging from 20 – 100 mg/mL were used to determine the effect on APTT, PT, and TT, in vitro by using normal coagulation plasma. Total phenolics and flavonoids contents in the extracts were determined using Folin-Ciocalteu and colorimetric assays with Gallic acid and Quecertin as standard respectively. Significance prolonged with 35 seconds seen at 100 mg/mL concentration of extract for APTT. On the other hands, PT started significant prolongation at 40 mg/mL concentration. TT displayed unreliable significant results at 20, 40 and 100 mg/mL concentration. By using Pearson’s correlation test revealed that only APTT and PT tests are significantly correlated to TPC and for TFC showed significantly correlated with PT. In summary, TFC and TPC found in Rhodomyrtus tomentosa contribute to anticoagulant activity. It is recommended to identify specific compound that responsible for anticoagulant effect of Rhodomyrtus tomentosa. 2017 Thesis https://ir.uitm.edu.my/id/eprint/50365/ https://ir.uitm.edu.my/id/eprint/50365/1/50365.pdf text en public degree Universiti Teknologi MARA ( Kampus Puncak Alam ) Faculty of Health Sciences Kamarudin, Evana
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Kamarudin, Evana
topic	Botanical chemistry Phytochemicals Drugs and their actions Botanical chemistry Phytochemicals
spellingShingle	Botanical chemistry Phytochemicals Drugs and their actions Botanical chemistry Phytochemicals Mohamad Norzaini, Rabiul Hamizah In vitro haemostatic activity of rhodomyrtus tomentosa methanol stem extract / Rabiul Hamizah Mohamad Norzaini
description	Anticoagulants from natural origins can be a good source to treat haemostatic disorders. One of them is, a rose myrtle (Rhodomyrtus tomentosa (Aiton) Hassk.), locally known as ‘kemunting’. This study aimed to determine the haemostatic activity of Rhodomyrtus tomentosa methanol stem extract concentration ranging from 20 – 100 mg/mL were used to determine the effect on APTT, PT, and TT, in vitro by using normal coagulation plasma. Total phenolics and flavonoids contents in the extracts were determined using Folin-Ciocalteu and colorimetric assays with Gallic acid and Quecertin as standard respectively. Significance prolonged with 35 seconds seen at 100 mg/mL concentration of extract for APTT. On the other hands, PT started significant prolongation at 40 mg/mL concentration. TT displayed unreliable significant results at 20, 40 and 100 mg/mL concentration. By using Pearson’s correlation test revealed that only APTT and PT tests are significantly correlated to TPC and for TFC showed significantly correlated with PT. In summary, TFC and TPC found in Rhodomyrtus tomentosa contribute to anticoagulant activity. It is recommended to identify specific compound that responsible for anticoagulant effect of Rhodomyrtus tomentosa.
format	Thesis
qualification_level	Bachelor degree
author	Mohamad Norzaini, Rabiul Hamizah
author_facet	Mohamad Norzaini, Rabiul Hamizah
author_sort	Mohamad Norzaini, Rabiul Hamizah
title	In vitro haemostatic activity of rhodomyrtus tomentosa methanol stem extract / Rabiul Hamizah Mohamad Norzaini
title_short	In vitro haemostatic activity of rhodomyrtus tomentosa methanol stem extract / Rabiul Hamizah Mohamad Norzaini
title_full	In vitro haemostatic activity of rhodomyrtus tomentosa methanol stem extract / Rabiul Hamizah Mohamad Norzaini
title_fullStr	In vitro haemostatic activity of rhodomyrtus tomentosa methanol stem extract / Rabiul Hamizah Mohamad Norzaini
title_full_unstemmed	In vitro haemostatic activity of rhodomyrtus tomentosa methanol stem extract / Rabiul Hamizah Mohamad Norzaini
title_sort	in vitro haemostatic activity of rhodomyrtus tomentosa methanol stem extract / rabiul hamizah mohamad norzaini
granting_institution	Universiti Teknologi MARA ( Kampus Puncak Alam )
granting_department	Faculty of Health Sciences
publishDate	2017
url	https://ir.uitm.edu.my/id/eprint/50365/1/50365.pdf
_version_	1783734830926659584

In vitro haemostatic activity of rhodomyrtus tomentosa methanol stem extract / Rabiul Hamizah Mohamad Norzaini

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