Comparison of antimicrobial activities between ethanol and aqueous extracts of ziziphus mauritiana leaves against urinary tract infections microorganisms / Fatin Najihah Mohd Noh

Urinary Tract Infections (UTIs) is one of the most frequent bacterial infections both in inpatient and outpatient clinical settings. In recent years, it has been reported the clinical available treatment is not effective due to the ability of bacteria to develop resistance against antimicrobial agen...

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Main Author:	Mohd Noh, Fatin Najihah
Format:	Thesis
Language:	English
Published:	2019
Subjects:	Botanical chemistry Phytochemicals Antibacterial agents
Online Access:	https://ir.uitm.edu.my/id/eprint/50493/1/50493.pdf
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id	my-uitm-ir.50493
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spelling	my-uitm-ir.504932021-09-15T01:45:19Z Comparison of antimicrobial activities between ethanol and aqueous extracts of ziziphus mauritiana leaves against urinary tract infections microorganisms / Fatin Najihah Mohd Noh 2019 Mohd Noh, Fatin Najihah Botanical chemistry. Phytochemicals Diseases of the genitourinary system. Urology Antibacterial agents Urinary Tract Infections (UTIs) is one of the most frequent bacterial infections both in inpatient and outpatient clinical settings. In recent years, it has been reported the clinical available treatment is not effective due to the ability of bacteria to develop resistance against antimicrobial agents. Therefore, the interest in drugs derives from plant become widespread as it is safe and economic compared than synthetic drug. On the other hand, plants have been used as a main source of therapeutics since ancient time until now. Ziziphus mauritiana belong to the family of Rhamnaceae and known to have some medical benefits such as anti-diarrheal and antimicrobial. In the present study, ethanol and aqueous extract of Z. mauritiana leaves were screened for potential antibacterial activity toward UTIs bacteria. The aim of the present study is to compare the antimicrobial activities between ethanol and aqueous extract of Z. mauritina leave against Urinary Tract Infections (UTIs) bacteria which are Staphylococcus saprophyticus, Klebsiella pneumoniae, Escherichia coli and Proteus mirabilis. The antimicrobial activities are determined by using disc diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) method. The result for ethanol extract of Z. mauritiana leaves against UTI bacteria showing only S. saprophyticus and K. pneumoniae showed the presence of zone inhibition with mean of 8.00 mm and 9.67 mm respectively while P. mirabilis and E. coli showed no zone of inhibition. The MIC and MBC value for S. saprophyticus were 31.25 mg/ml and 125 mg/ml respectively. Meanwhile, MIC and MBC value for K. pneumoniae were 15.63 mg/ml and 31.25 mg/ml respectively. In contrast, the aqueous extract of Z. mauritiana leaves produced no inhibitory effect against S. saprophyticus, K. pneumoniae, E coli and P. mirabilis. Thus, ethanol extract of Z. mauritiana leaves possess antibacterial activities rather than aqueous extract. The findings showed the potency of alcoholic solvent such as ethanol in extracting component of medicinal plants compare than aqueous extract. 2019 Thesis https://ir.uitm.edu.my/id/eprint/50493/ https://ir.uitm.edu.my/id/eprint/50493/1/50493.pdf text en public degree Universiti Teknologi MARA (Kampus Puncak Alam) Faculty of Health Sciences Rambely, Azlin Sham
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Rambely, Azlin Sham
topic	Botanical chemistry Phytochemicals Botanical chemistry Phytochemicals Antibacterial agents
spellingShingle	Botanical chemistry Phytochemicals Botanical chemistry Phytochemicals Antibacterial agents Mohd Noh, Fatin Najihah Comparison of antimicrobial activities between ethanol and aqueous extracts of ziziphus mauritiana leaves against urinary tract infections microorganisms / Fatin Najihah Mohd Noh
description	Urinary Tract Infections (UTIs) is one of the most frequent bacterial infections both in inpatient and outpatient clinical settings. In recent years, it has been reported the clinical available treatment is not effective due to the ability of bacteria to develop resistance against antimicrobial agents. Therefore, the interest in drugs derives from plant become widespread as it is safe and economic compared than synthetic drug. On the other hand, plants have been used as a main source of therapeutics since ancient time until now. Ziziphus mauritiana belong to the family of Rhamnaceae and known to have some medical benefits such as anti-diarrheal and antimicrobial. In the present study, ethanol and aqueous extract of Z. mauritiana leaves were screened for potential antibacterial activity toward UTIs bacteria. The aim of the present study is to compare the antimicrobial activities between ethanol and aqueous extract of Z. mauritina leave against Urinary Tract Infections (UTIs) bacteria which are Staphylococcus saprophyticus, Klebsiella pneumoniae, Escherichia coli and Proteus mirabilis. The antimicrobial activities are determined by using disc diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) method. The result for ethanol extract of Z. mauritiana leaves against UTI bacteria showing only S. saprophyticus and K. pneumoniae showed the presence of zone inhibition with mean of 8.00 mm and 9.67 mm respectively while P. mirabilis and E. coli showed no zone of inhibition. The MIC and MBC value for S. saprophyticus were 31.25 mg/ml and 125 mg/ml respectively. Meanwhile, MIC and MBC value for K. pneumoniae were 15.63 mg/ml and 31.25 mg/ml respectively. In contrast, the aqueous extract of Z. mauritiana leaves produced no inhibitory effect against S. saprophyticus, K. pneumoniae, E coli and P. mirabilis. Thus, ethanol extract of Z. mauritiana leaves possess antibacterial activities rather than aqueous extract. The findings showed the potency of alcoholic solvent such as ethanol in extracting component of medicinal plants compare than aqueous extract.
format	Thesis
qualification_level	Bachelor degree
author	Mohd Noh, Fatin Najihah
author_facet	Mohd Noh, Fatin Najihah
author_sort	Mohd Noh, Fatin Najihah
title	Comparison of antimicrobial activities between ethanol and aqueous extracts of ziziphus mauritiana leaves against urinary tract infections microorganisms / Fatin Najihah Mohd Noh
title_short	Comparison of antimicrobial activities between ethanol and aqueous extracts of ziziphus mauritiana leaves against urinary tract infections microorganisms / Fatin Najihah Mohd Noh
title_full	Comparison of antimicrobial activities between ethanol and aqueous extracts of ziziphus mauritiana leaves against urinary tract infections microorganisms / Fatin Najihah Mohd Noh
title_fullStr	Comparison of antimicrobial activities between ethanol and aqueous extracts of ziziphus mauritiana leaves against urinary tract infections microorganisms / Fatin Najihah Mohd Noh
title_full_unstemmed	Comparison of antimicrobial activities between ethanol and aqueous extracts of ziziphus mauritiana leaves against urinary tract infections microorganisms / Fatin Najihah Mohd Noh
title_sort	comparison of antimicrobial activities between ethanol and aqueous extracts of ziziphus mauritiana leaves against urinary tract infections microorganisms / fatin najihah mohd noh
granting_institution	Universiti Teknologi MARA (Kampus Puncak Alam)
granting_department	Faculty of Health Sciences
publishDate	2019
url	https://ir.uitm.edu.my/id/eprint/50493/1/50493.pdf
_version_	1783734835010863104

Comparison of antimicrobial activities between ethanol and aqueous extracts of ziziphus mauritiana leaves against urinary tract infections microorganisms / Fatin Najihah Mohd Noh

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