The impact of vitamin D on clinical parameters and the bone turnover biomakers in ligature induced periodontitis: experimental study in rats / Muhammad Hilmi Zainal Ariffin

Periodontal disease is a multifactorial disease process involving the host and microbial challenges. Nutritional Vitamin D has been associated as a modifying factor to periodontal diseases. The aim of this study was to evaluate the effect of vitamin D on the clinical, radiographical and serum level...

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Main Author:	Zainal Ariffin, Muhammad Hilmi
Format:	Thesis
Language:	English
Published:	2020
Subjects:	RK Dentistry
Online Access:	https://ir.uitm.edu.my/id/eprint/53642/1/53642.pdf
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spelling	my-uitm-ir.536422022-03-28T06:21:03Z The impact of vitamin D on clinical parameters and the bone turnover biomakers in ligature induced periodontitis: experimental study in rats / Muhammad Hilmi Zainal Ariffin 2020-10 Zainal Ariffin, Muhammad Hilmi RK Dentistry Oral and dental medicine. Pathology. Diseases Periodontal disease is a multifactorial disease process involving the host and microbial challenges. Nutritional Vitamin D has been associated as a modifying factor to periodontal diseases. The aim of this study was to evaluate the effect of vitamin D on the clinical, radiographical and serum level changes of OPG, DKK1, SOST, and FGF23 in a ligature induced periodontitis, an experiment study in rats. A total of 28 rats were included in this study and divided into test groups of Vitamin D supplement, Vitamin D deficient and control. A ligature placed around the bilateral mandibular incisor for 2 weeks to induce periodontal tissue destruction. Clinical attachment and Radiographical changes were recorded as well as serum sample was tested for OPG, DKK1, SOST, and FGF23. Two weeks after ligature placement, gingival inflammations were induced. Groups that were made Vitamin D deficient exhibited greater amount of clinical attachment loss (1.05 ± 0.50 mm) as compared to control (0.83 ± 0.14 mm) and groups with supplemented Vitamin D at (0.60 ± 0.13 mm) showing significant differences (p <0.05). Amount of radiographic alveolar bone loss was greater were seen in Vitamin D deficient (0.61 ± 0.06mm) as compared to control (0.45 ± 0.04 mm) and groups with supplemented Vitamin D at (0.26 ± 0.03 mm) showing significant differences (p <0.05). Vitamin D deficient groups also exhibited a statistically significant reduction in levels of OPG (421.65 ± 29.49 pg/ml) compared to Control Groups (584.84 ± 137.96 pg/ml), and Vitamin D Supplemented group (715.68 ± 71.37 pg/ml). Vitamin D deficient groups exhibited higher concentrations of DKK1 at (1336.56 ± 272.71 pg/ml) compared to Control Groups (1243.86 ± 207.40 pg/ml) and Vitamin D Supplemented group (909.42 ± 149.06 pg/ml). SOST concentration was higher in Vitamin D deficient groups (1684.12 ± 41.92 pg/ml) compared to Control Groups (1682.14 ± 41.92) and Vitamin D Supplemented group (1284.22 ± 34.20 pg/ml), and FGF23 concentration was higher in Vitamin D deficient groups (531.09 ± 12.84 pg/ml) compared to Control Groups (627.11 ± 18.58 pg/ml), Vitamin D Supplemented group (717.79 ± 20.45 pg/ml). The results revealed that vitamin D supplementation may have a role in periodontal disease progression. It shows bone turnover biomarkers related to resorption increase in concentration in group with vitamin D deficiency and reduced in vitamin D supplementation group. 2020-10 Thesis https://ir.uitm.edu.my/id/eprint/53642/ https://ir.uitm.edu.my/id/eprint/53642/1/53642.pdf text en public phd doctoral Universiti Teknologi MARA Faculty of Dentistry Hidayat, Faizal Hafez (Dr.) Al- Bayati, Fouad Hussain (Prof.)
institution	Universiti Teknologi MARA
collection	UiTM Institutional Repository
language	English
advisor	Hidayat, Faizal Hafez (Dr.) Al- Bayati, Fouad Hussain (Prof.)
topic	RK Dentistry RK Dentistry
spellingShingle	RK Dentistry RK Dentistry Zainal Ariffin, Muhammad Hilmi The impact of vitamin D on clinical parameters and the bone turnover biomakers in ligature induced periodontitis: experimental study in rats / Muhammad Hilmi Zainal Ariffin
description	Periodontal disease is a multifactorial disease process involving the host and microbial challenges. Nutritional Vitamin D has been associated as a modifying factor to periodontal diseases. The aim of this study was to evaluate the effect of vitamin D on the clinical, radiographical and serum level changes of OPG, DKK1, SOST, and FGF23 in a ligature induced periodontitis, an experiment study in rats. A total of 28 rats were included in this study and divided into test groups of Vitamin D supplement, Vitamin D deficient and control. A ligature placed around the bilateral mandibular incisor for 2 weeks to induce periodontal tissue destruction. Clinical attachment and Radiographical changes were recorded as well as serum sample was tested for OPG, DKK1, SOST, and FGF23. Two weeks after ligature placement, gingival inflammations were induced. Groups that were made Vitamin D deficient exhibited greater amount of clinical attachment loss (1.05 ± 0.50 mm) as compared to control (0.83 ± 0.14 mm) and groups with supplemented Vitamin D at (0.60 ± 0.13 mm) showing significant differences (p <0.05). Amount of radiographic alveolar bone loss was greater were seen in Vitamin D deficient (0.61 ± 0.06mm) as compared to control (0.45 ± 0.04 mm) and groups with supplemented Vitamin D at (0.26 ± 0.03 mm) showing significant differences (p <0.05). Vitamin D deficient groups also exhibited a statistically significant reduction in levels of OPG (421.65 ± 29.49 pg/ml) compared to Control Groups (584.84 ± 137.96 pg/ml), and Vitamin D Supplemented group (715.68 ± 71.37 pg/ml). Vitamin D deficient groups exhibited higher concentrations of DKK1 at (1336.56 ± 272.71 pg/ml) compared to Control Groups (1243.86 ± 207.40 pg/ml) and Vitamin D Supplemented group (909.42 ± 149.06 pg/ml). SOST concentration was higher in Vitamin D deficient groups (1684.12 ± 41.92 pg/ml) compared to Control Groups (1682.14 ± 41.92) and Vitamin D Supplemented group (1284.22 ± 34.20 pg/ml), and FGF23 concentration was higher in Vitamin D deficient groups (531.09 ± 12.84 pg/ml) compared to Control Groups (627.11 ± 18.58 pg/ml), Vitamin D Supplemented group (717.79 ± 20.45 pg/ml). The results revealed that vitamin D supplementation may have a role in periodontal disease progression. It shows bone turnover biomarkers related to resorption increase in concentration in group with vitamin D deficiency and reduced in vitamin D supplementation group.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Zainal Ariffin, Muhammad Hilmi
author_facet	Zainal Ariffin, Muhammad Hilmi
author_sort	Zainal Ariffin, Muhammad Hilmi
title	The impact of vitamin D on clinical parameters and the bone turnover biomakers in ligature induced periodontitis: experimental study in rats / Muhammad Hilmi Zainal Ariffin
title_short	The impact of vitamin D on clinical parameters and the bone turnover biomakers in ligature induced periodontitis: experimental study in rats / Muhammad Hilmi Zainal Ariffin
title_full	The impact of vitamin D on clinical parameters and the bone turnover biomakers in ligature induced periodontitis: experimental study in rats / Muhammad Hilmi Zainal Ariffin
title_fullStr	The impact of vitamin D on clinical parameters and the bone turnover biomakers in ligature induced periodontitis: experimental study in rats / Muhammad Hilmi Zainal Ariffin
title_full_unstemmed	The impact of vitamin D on clinical parameters and the bone turnover biomakers in ligature induced periodontitis: experimental study in rats / Muhammad Hilmi Zainal Ariffin
title_sort	impact of vitamin d on clinical parameters and the bone turnover biomakers in ligature induced periodontitis: experimental study in rats / muhammad hilmi zainal ariffin
granting_institution	Universiti Teknologi MARA
granting_department	Faculty of Dentistry
publishDate	2020
url	https://ir.uitm.edu.my/id/eprint/53642/1/53642.pdf
_version_	1783734876750479360

The impact of vitamin D on clinical parameters and the bone turnover biomakers in ligature induced periodontitis: experimental study in rats / Muhammad Hilmi Zainal Ariffin

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